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Comorbid and Secondary Depression

  • Margaret S. Andover
  • Genevieve N. Izzo
  • Chris A. Kelly
Chapter

Abstract

A high rate of comorbidity between anxiety and depressive disorders has been demonstrated in children and adolescents as well as adults. Rates of depressive disorders in children and adolescents with anxiety disorders range as high as 70%, higher than one would expect by chance (Angold, Costello, & Erkanli, 1999; Kovacs & Devlin, 1998). This significant comorbidity has been reported in both community and clinical samples of youth (Angold, Costello, & Erkanli, 1999; Brady & Kendall, 1992; Kovacs & Devlin, 1998; Seligman & Ollendick, 1998). Comorbidity is associated with a more severe course of psychopathology than anxiety or depressive disorders alone (Brady & Kendall, 1992; Seligman & Ollendick, 1998), including more severe depressive symptoms (Costello, Mustillo, Erkanli, Keeler, & Angold, 2003; Merikangas et al., 2003; Moffitt et al., 2007) and greater risk for suicidality (Foley, Goldston, Costello, & Angold, 2006). For example, Hammen, Brennan, Keenan-Miller, and Herr (2008) found that among youth with early onset depression, those with comorbid anxiety disorders were at particular risk for recurrent depression. Similarly, Wittchen and Fehm (2003) report that individuals with comorbid social anxiety disorder and depression were more likely to experience additional depressive episodes and less likely to experience a remission in depression than individuals without social anxiety disorder. In this chapter, we present an overview of issues pertinent to the understanding of comorbid anxiety and depression among children and adolescents. Specifically, we will discuss models of conceptualizing comorbidity and the risk factors, outcomes, and clinical implications of comorbid anxiety and depression.

Keywords

Major Depressive Disorder Anxiety Disorder Generalize Anxiety Disorder Social Anxiety Disorder Childhood Anxiety 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

References

  1. Alfano, C. A., Beidel, D. C., & Turner, S. M. (2002). Cognition in childhood anxiety: Conceptual, methodological, and developmental issues. Clinical Psychology Review, 22, 1209–1238.PubMedGoogle Scholar
  2. Anderson, E. R., & Hope, D. A. (2008). A review of the tripartite model for understanding the link between anxiety and depression in youth. Clinical Psychology Review, 28, 275–287.PubMedGoogle Scholar
  3. Angold, A., Costello, E. J., & Erkanli, A. (1999). Comorbidity. Journal of Child Psychology and Psychiatry, 40, 57–87.PubMedGoogle Scholar
  4. Angold, A., Costello, E. J., Farmer, E. M. Z., Burns, B. J., & Erkanli, A. (1999). Impaired but undiagnosed. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 129–137.Google Scholar
  5. Angold, A., Costello, E. J., & Worthman, C. M. (1998). Puberty and depression: The roles of age, pubertal status and pubertal timing. Psychological Medicine, 28, 51–61.PubMedGoogle Scholar
  6. Arbelle, S., Benjamin, J., Golin, M., Kremer, I., Belmaker, R. H., & Ebstein, R. P. (2003). Relation of shyness in grade school children to the genotype for the long form of the serotonin transporter promoter region polymorphism. American Journal of Psychiatry, 160, 671–676.PubMedGoogle Scholar
  7. Avenevoli, S., Stolar, M., Li, J., Dierker, L., & Ries Merikangas, K. (2001). Comorbidity of depression in children and adolescents: Models and evidence from a prospective high-risk family study. Biological Psychiatry, 49, 1071–1081.PubMedGoogle Scholar
  8. Bale, T. L. (2006). Stress sensitivity and the development of affective disorders. Hormones and Behavior, 50, 529–533.PubMedGoogle Scholar
  9. Bao, A. M., Meynen, G., & Swaab, D. F. (2008). The stress system in depression and neurodegeneration: Focus on the human hypothalamus. Brain Research Reviews, 57, 531–553.PubMedGoogle Scholar
  10. Barlow, D. H. (2000). Unraveling the mysteries of anxiety and its disorders from the perspective of emotion theory. American Psychologist, 55, 1247–1263.PubMedGoogle Scholar
  11. Barlow, D. H., & Campbell, L. A. (2000). Mixed anxiety-depression and its implications for models of mood and anxiety disorders. Comprehensive Psychiatry, 41, 55–60.PubMedGoogle Scholar
  12. Beardslee, W. R., Keller, M. B., Lavori, P. W., & Staley, J. E. (1993). The impact of parental affective disorder on depression in offspring: A longitudinal follow-up in a nonreferred sample. Journal of the American Academy of Child & Adolescent Psychiatry, 32, 723–730.Google Scholar
  13. Beck, A. T., Rush, A. J., Shaw, B. F., & Emery, G. (1979). Cognitive therapy of depression. New York: Guilford Press.Google Scholar
  14. Beesdo, K., Bittner, A., Pine, D. S., Stein, M. B., Hofler, M., Lieb, R., et al. (2007). Incidence of Social Anxiety Disorder and the consistent risk for secondary depression in the first three decades of life. Archives of General Psychiatry, 64, 903–912.PubMedGoogle Scholar
  15. Beesdo, K., Lau, J. Y., Guyer, A. E., McClure-Tone, E. B., Monk, C. S., Nelson, E. E., et al. (2009). Common and distinct amygdala-function perturbations in depressed vs anxious adolescents. Archives of General Psychiatry, 66, 275–285.PubMedGoogle Scholar
  16. Beidel, D. C., & Turner, S. M. (1997). At risk for anxiety: I. Psychopathology in the offspring of anxious parents. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 918–924.Google Scholar
  17. Beidel, D. C., & Turner, S. M. (1998). Shy children, phobic adults: nature and treatment of social phobia. Washington, DC: American Psychological Association.Google Scholar
  18. Bittner, A., Egger, H. L., Erkanli, A., Costello, E. J., Foley, D. L., & Angold, A. (2007). What do childhood anxiety disorders predict? Journal of Child Psychology and Psychiatry, 48, 1174–1183.PubMedGoogle Scholar
  19. Bittner, A., Goodwin, R. D., Wittchen, H.-U., Beesdo, K., Hofler, M., & Lieb, R. (2004). What characteristics of primary anxiety disorders predict subsequent major depressive disorder? Journal of Clinical Psychiatry, 65, 618–626.PubMedGoogle Scholar
  20. Bogels, S. M., & Zigterman, D. (2000). Dysfunctional cognitions in children with social phobia, separation anxiety disorder, and generalized anxiety disorder. Journal of Abnormal Child Psychology, 28, 205–211.PubMedGoogle Scholar
  21. Boomsma, D. I., van Beijsterveldt, C. E., & Hudziak, J. J. (2005). Genetic and environmental influences on anxious/depression during childhood: A study from the Netherlands Twin Register. Genes, Brain and Behavior, 4, 466–481.Google Scholar
  22. Borkovec, T. D., Abel, J. L., & Newman, H. (1995). Effects of psychotherapy on comorbid conditions in generalized anxiety disorder. Journal of Consulting and Clinical Psychology, 63, 479–483.PubMedGoogle Scholar
  23. Brady, E. U., & Kendall, P. C. (1992). Comorbidity of anxiety and depression in children and adolescents. Psychological Bulletin, 111, 244–255.PubMedGoogle Scholar
  24. Brown, T. A., & Barlow, D. H. (1992). Comorbidity among anxiety disorders: Implications for treatment and DSM-IV. Journal of Consulting and Clinical Psychology, 60, 835–840.PubMedGoogle Scholar
  25. Brown, T. A., & Barlow, D. H. (2009). A proposal for a dimensional classification system based on the shared features of the DSM-IV anxiety and mood disorders: Implications for assessment and treatment. Psychological Assessment, 21, 256–271.PubMedGoogle Scholar
  26. Bruder, G. E., Fong, R., Tenke, C. E., Leite, P., Towey, J. P., Stewart, J. E., et al. (1997). Regional brain asymmetries in major depression with or without an anxiety disorder: A quantitative electroencephalographic study. Biological Psychiatry, 41, 939–948.PubMedGoogle Scholar
  27. Cameron, O. G. (2006). Anxious-depressive comorbidity: Effects on HPA axis and CNS noradrenergic functions. Essential Psychopharmacology, 7, 24–34.PubMedGoogle Scholar
  28. Cannon, M. F., & Weems, C. F. (2006). Do anxiety and depression cluster into distinct groups?: A test of tripartite model predictions in a community sample of youth. Depression and Anxiety, 23, 453–460.PubMedGoogle Scholar
  29. Caspi, A., Sugden, K., Moffitt, T. E., Taylor, A., Craig, I. W., Harrington, H., et al. (2003). Influence of life stress on depression: Moderation by a polymorphism in the 5-HTT gene. Science, 301, 386–389.PubMedGoogle Scholar
  30. Cerdá, M., Sagdeo, A., Johnson, J., & Galea, S. (2010). Genetic and environmental influences on psychiatric comorbidity: A systematic review. Journal of Affective Disorders, 126, 14–38. doi:S0165-0327(09)00499-6.PubMedGoogle Scholar
  31. Charbonneau, A. M., Mezulis, A. H., & Hyde, J. S. (2009). Stress and emotional reactivity as explanations for gender differences in adolescents’ depressive symptoms. Journal of Youth and Adolescence, 38, 1050–1058.PubMedGoogle Scholar
  32. Chorpita, B. F., Albano, A. M., & Barlow, D. H. (1998). The structure of negative emotions in a clinical sample of children and adolescents. Journal of Abnormal Psychology, 107, 74–85.PubMedGoogle Scholar
  33. Chorpita, B. F., Plummer, C. M., & Moffitt, C. E. (2000). Relations of tripartite dimensions of emotion to childhood anxiety and mood disorders. Journal of Abnormal Child Psychology, 28, 299–310.PubMedGoogle Scholar
  34. Cicchetti, D., & Toth, S. L. (1998). The development of depression in children and adolescents. American Psychologist, 53, 221–241.PubMedGoogle Scholar
  35. Clark, L. A., & Watson, D. (1991). Tripartite model of anxiety and depression: Psychometric evidence and taxometric implications. Journal of Abnormal Psychology, 100, 316–336.PubMedGoogle Scholar
  36. Clark, L. A., Watson, D., & Mineka, S. (1994). Temperament, personality, and the mood and anxiety disorders. Journal of Abnormal Psychology, 103, 103–116.PubMedGoogle Scholar
  37. Cole, D. A., Truglio, R., & Peeke, L. (1997). Relation between symptoms of anxiety and depression in children: A multitrait-multimethod-multigroup assessment. Journal of Consulting and Clinical Psychology, 65, 110–119.PubMedGoogle Scholar
  38. Compas, B. E., Connor-Smith, J., & Jaser, S. S. (2004). Temperament, stress reactivity, and coping: Implications for depression in childhood and adolescence. Journal of Clinical Child and Adolescent Psychology, 33, 21–31.PubMedGoogle Scholar
  39. Compas, B. E., Oppedisano, G., Sameroff, A. J., Lewis, M., & Miller, S. M. (2000). Mixed anxiety/depression in childhood and adolescence. In A. J. Sameroff, M. Lewis, & S. M. Miller (Eds.), Handbook of developmental psychopathology (2nd ed., pp. 531–548). Dordrecht: Kluwer Academic Publishers.Google Scholar
  40. Connell, A. M., & Goodman, S. H. (2002). The association between psychopathology in fathers versus mothers and children’s internalizing and externalizing behavior problems: A meta-analysis. Psychological Bulletin, 128, 746–773.PubMedGoogle Scholar
  41. Costello, E. J., Mustillo, S., Erkanli, A., Keeler, G., & Angold, A. (2003). Prevalence and development of psychiatric disorders in childhood and adolescence. Archives of General Psychiatry, 60(8), 837–844.PubMedGoogle Scholar
  42. Costello, E. J., Pine, D. S., Hammen, C., March, J. S., Plotsky, P. M., Weissman, M. M., et al. (2002). Development and natural history of mood disorders. Biological Psychiatry, 52, 529–542.PubMedGoogle Scholar
  43. Cox, B. J., Taylor, S., & Enns, M. W. (1999). Fear of cognitive dyscontrol in relation to depression symptoms: Comparisons between original and alternative measures of anxiety sensitivity. Journal of Behavior Therapy and Experimental Psychiatry, 30, 301–311.PubMedGoogle Scholar
  44. Davidson, R. J., Elkman, P., Saron, C., Senulis, R., & Friesen, W. V. (1990). Approach-withdrawal and cerebral asymmetry: I. Emotional expression and brain physiology. Journal of Personality and Social Psychology, 58, 330–341.PubMedGoogle Scholar
  45. Dearing, K. F., & Gotlib, I. H. (2009). Interpretation of ambiguous information in girls at risk for depression. Journal of Abnormal Child Psychology, 37, 79–91.PubMedGoogle Scholar
  46. Eaves, L., Silberg, J., & Erkanli, A. (2003). Resolving multiple epigenetic pathways to adolescent depression. Journal of Child Psychology and Psychiatry, 44, 1006–1014.PubMedGoogle Scholar
  47. Ehringer, M. A., Rhee, S. H., Young, S., Corley, R., & Hewitt, J. K. (2006). Genetic and environmental contributions to common psychopathologies of childhood and adolescence: A study of twins and their siblings. Journal of Abnormal Child Psychology, 34, 1–17.PubMedGoogle Scholar
  48. Eley, T. C., & Stevenson, J. (1999). Exploring the covariation between anxiety and depression symptoms: A genetic analysis of the effects of age and sex. Journal of Child Psychology and Psychiatry, 40, 1273–1282.PubMedGoogle Scholar
  49. Epkins, C. C. (1996). Cognitive specificity and affective confounding in social anxiety and dysphoria in children: Negative affectivity or independent constructs? Journal of Psychopathology and Behavioral Assessment, 18, 83–101.Google Scholar
  50. Essex, M. J., Klein, M. H., Cho, E., & Kraemer, H. C. (2003). Exposure to maternal depression and marital conflict: Gender differences in children’s later mental health symptoms. Journal of the American Academy of Child & Adolescent Psychiatry, 42, 728–737.Google Scholar
  51. Essex, M. J., Kraemer, H. C., Armstrong, J. M., Boyce, W. T., Goldsmith, H. H., Klein, M. H., et al. (2006). Exploring risk factors for the emergence of children’s mental health problems. Archives of General Psychiatry, 63, 1246–1256.PubMedGoogle Scholar
  52. Fergusson, D. M., Horwood, L. J., & Boden, J. M. (2006). Structure of internalising symptoms in early adulthood. British Journal of Psychiatry, 189, 540–546.PubMedGoogle Scholar
  53. Foley, D. L., Goldston, D. B., Costello, E. J., & Angold, A. (2006). Proximal psychiatric risk factors for suicidality in youth: The Great Smoky Mountains study. Archives of General Psychiatry, 63, 1017–1024.PubMedGoogle Scholar
  54. Fombonne, E., Wostear, G., Cooper, V., Harrington, R., & Rutter, M. (2001). The Maudsley long-term follow-up of child and adolescent depression: 1. Psychiatric outcomes in adulthood. British Journal of Psychiatry, 179, 210–217.PubMedGoogle Scholar
  55. Forbes, E. E., Hariri, A. R., Martin, S. L., Silk, J. S., Moyles, D. L., Fisher, P. M., et al. (2009). Altered striatal activation predicting real-world positive affect in adolescent major depressive disorder. American Journal of Psychiatry, 166, 64–73.PubMedGoogle Scholar
  56. Fox, N. A., Henderson, H. A., Marshall, P. J., Nichols, K. E., & Ghera, M. M. (2005). Behavioral inhibition: Linking biology and behavior within a developmental framework. Annual Review of Psychology, 56, 235–262.PubMedGoogle Scholar
  57. Fresco, D. M., Alloy, L. B., & Reilly-Harrington, N. (2006). Association of attributional style for negative and positive events and the occurrence of life events with depression and anxiety. Journal of Social and Clinical Psychology, 25, 1140–1159.Google Scholar
  58. Garber, J., Gallerani, C. M., Frankel, S. A., Gotlib, I. H., & Hammen, C. L. (2009). Depression in children. In I. H. Gotlib & C. L. Hammen (Eds.), Handbook of depression (2nd ed., pp. 405–443). New York: Guilford Press.Google Scholar
  59. Gasic, G. P., Smoller, J. W., Perlis, R. H., Sun, M., Lee, S., Kim, B. W., et al. (2009). BDNF, relative preference, and reward circuitry responses to emotional communication. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 150B, 762–781.Google Scholar
  60. Glover, V., O’Connor, T. G., & O’Donnell, K. (2010). Prenatal stress and the programming of the HPA axis. Neuroscience and Biobehavioral Reviews, 35, 17–22. PubMedGoogle Scholar
  61. Goldsmith, H. H., Pollak, S. D., & Davidson, R. J. (2008). Developmental neuroscience perspectives on emotion regulation. Child Development Perspectives, 2, 132–140.PubMedGoogle Scholar
  62. Grillon, C., Warner, V., Hille, J., Merikangas, K. R., Bruder, G. E., Tenke, C. E., et al. (2005). Families at high and low risk for depression: A three-generation startle study. Biological Psychiatry, 57, 953–960.PubMedGoogle Scholar
  63. Hammen, C., Brennan, P. A., Keenan-Miller, D., & Herr, N. R. (2008). Early onset recurrent subtype of adolescent depression: Clinical and psychosocial correlates. Journal of Child Psychology and Psychiatry, 49, 433–440.PubMedGoogle Scholar
  64. Hankin, B. L. (2008). Cognitive vulnerability-stress model of depression during adolescence: Investigating depressive symptom specificity in a multi-wave prospective study. Journal of Abnormal Child Psychology, 36, 999–1014.PubMedGoogle Scholar
  65. Hare, T. A., Tottenham, N., Galvan, A., Voss, H. U., Glover, G. H., & Casey, B. J. (2008). Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-nogo task. Biological Psychiatry, 63, 927–934.PubMedGoogle Scholar
  66. Heller, W., & Nitschke, J. B. (1998). The puzzle of regional brain activity in depression and anxiety: The importance of subtypes and comorbidity. Cognition and Emotion, 12, 421–447.Google Scholar
  67. Hirshfeld-Becker, D. R., Micco, J., Henin, A., Bloomfield, A., Biederman, J., & Rosenbaum, J. (2008). Behavioral inhibition. Depression and Anxiety, 25, 357–367.PubMedGoogle Scholar
  68. Hyde, J. S., Mezulis, A. H., & Abramson, L. Y. (2008). The ABCs of depression: Integrating affective, biological, and cognitive models to explain the emergence of the gender difference in depression. Psychological Review, 115, 291–313.PubMedGoogle Scholar
  69. Kagan, J., & Snidman, N. (1999). Early childhood predictors of adult anxiety disorders. Biological Psychiatry, 46, 1536–1541.PubMedGoogle Scholar
  70. Kallen, V. L., Tulen, J. H., Utens, E. M., Treffers, P. D., De Jong, F. H., & Ferdinand, R. F. (2008). Associations between HPA axis functioning and level of anxiety in children and adolescents with an anxiety disorder. Depression and Anxiety, 25, 131–141.PubMedGoogle Scholar
  71. Karevold, E., Røysamb, E., Ystrom, E., & Mathiesen, K. S. (2009). Predictors and pathways from infancy to symptoms of anxiety and depression in early adolescence. Developmental Psychology, 45, 1051–1060.PubMedGoogle Scholar
  72. Kendall, P. C., Brady, E. U., & Verduin, T. L. (2001). Comorbidity in childhood anxiety disorders and treatment outcome. Journal of the American Academy of Child and Adolescent Psychiatry, 40, 787–794.PubMedGoogle Scholar
  73. Kendall, P. C., Kortlander, E., Chansky, T. E., & Brady, E. U. (1992). Comorbidity of anxiety and depression in youth: Treatment implications. Journal of Consulting and Clinical Psychology, 60, 869–880.PubMedGoogle Scholar
  74. Kendler, K. S., Gardner, C. O., Gatz, M., & Pedersen, N. L. (2007). The sources of co-morbidity between major depression and generalized anxiety disorder in a Swedish national twin sample. Psychological Medicine, 37, 453–462.PubMedGoogle Scholar
  75. Kendler, K. S., & Karkowski-Shuman, L. (1997). Stressful life events and genetic liability to major depression: Genetic control of exposure to the environment? Psychological Medicine, 27, 539–547.PubMedGoogle Scholar
  76. Kendler, K. S., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1992). Major depression and generalized anxiety disorder. Same genes, (partly) different environments? Archives of General Psychiatry, 49, 716–722.PubMedGoogle Scholar
  77. Kendler, K. S., Walters, E. E., Neale, M. C., Kessler, R. C., Heath, A. C., & Eaves, L. J. (1995). The structure of the genetic and environmental risk factors for six major psychiatric disorders in women. Phobia, generalized anxiety disorder, panic disorder, bulimia, major depression, and alcoholism. Archives of General Psychiatry, 52, 374–383.PubMedGoogle Scholar
  78. Kentgen, L. M., Tenke, C. E., Pine, D. S., Fong, R., Klein, R. G., & Bruder, G. E. (2000). Electroen­cephalographic asymmetries in adolescents with major depression: Influence of comorbidity with anxiety disorders. Journal of Abnormal Psychology, 109, 797–802.PubMedGoogle Scholar
  79. Kessler, R. C., Davis, C. G., & Kendler, K. S. (1997). Childhood adversity and adult psychiatric disorder in the US National Comorbidity Survey. Psychological Medicine, 27, 1101–1119.PubMedGoogle Scholar
  80. Kessler, R. C., Gruber, M., Hettema, J. M., Hwang, I., Sampson, N., & Yonkers, K. A. (2008). Comorbid major depression and generalized anxiety disorders in the National Comorbidity Survey follow-up. Psychological Medicine, 38, 365–374.PubMedGoogle Scholar
  81. Kessler, R. C., Nelson, C. B., McGonagle, K. A., Liu, J., Swartz, M., & Blazer, D. G. (1996). Comorbidity of DSM-III-R major depressive disorder in the general population: Results from the US National Comorbidity Survey. British Journal of Psychiatry, 168, 17–30.Google Scholar
  82. Kessler, R. C., & Wang, P. S. (2008). The descriptive epidemiology of commonly occurring mental disorders in the United States. Annual Review of Public Health, 29, 115–129.PubMedGoogle Scholar
  83. Kessler, R. C., Zhao, S., Blazer, D. G., & Swartz, M. (1997). Prevalence, correlates, and course of minor depression and major depression in the national comorbidity survey. Journal of Affective Disorders, 45, 19–30.PubMedGoogle Scholar
  84. Klein, D. N., Santiago, N. J., Vivian, D., Blalock, J. A., Kocsis, J. H., Markowitz, J. C., et al. (2004). Cognitive-behavioral analysis system of psychotherapy as a maintenance treatment for chronic depression. Journal of Consulting and Clinical Psychology, 72, 681–688.PubMedGoogle Scholar
  85. Klerman, G. L., & Weissman, M. M. (1989). Increasing rates of depression. Journal of the American Medical Association, 261, 2229–2235.PubMedGoogle Scholar
  86. Koolschijn, P. C., van Haren, N. E., Lensvelt-Mulders, G. J., Hulshoff Pol, H. E., & Kahn, R. S. (2009). Brain volume abnormalities in major depressive disorder: A meta-analysis of magnetic resonance imaging studies. Human Brain Mapping, 30, 3719–3735.PubMedGoogle Scholar
  87. Kovacs, M., & Devlin, B. (1998). Internalizing disorders in childhood. Journal of Child Psychology and Psychiatry, 39, 47–63.PubMedGoogle Scholar
  88. Krueger, R. F., Caspi, A., Moffitt, T. E., Silva, P. A., & McGee, R. (1996). Personality traits are differentially linked to mental disorders: A multitrait-multidiagnosis study of an adolescent birth cohort. Journal of Abnormal Psychology, 105, 299–312.PubMedGoogle Scholar
  89. Krueger, R. F., & Markon, K. E. (2006). Reinterpreting comorbidity: A model-based approach to understanding and classifying psychopathology. Annual Review of Clinical Psychology, 2, 111–133.PubMedGoogle Scholar
  90. Last, C. G., Hansen, C., & Franco, N. (1997). Anxious children in adulthood: A prospective study of adjustment. Journal of the American Academy of Child & Adolescent Psychiatry, 36, 645–652.Google Scholar
  91. Last, C. G., Perrin, S., Hersen, M., & Kazdin, A. E. (1996). A prospective study of childhood anxiety disorders. Journal of the American Academy of Child & Adolescent Psychiatry, 35, 1502–1510.Google Scholar
  92. Lau, J. Y., Goldman, D., Buzas, B., Fromm, S. J., Guyer, A. E., Hodgkinson, C., et al. (2009). Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder. Biological Psychiatry, 65, 349–355.PubMedGoogle Scholar
  93. Lau, J. Y., Goldman, D., Buzas, B., Hodgkinson, C., Leibenluft, E., Nelson, E., et al. (2010). BDNF gene polymorphism (Val66Met) predicts amygdala and anterior hippocampus responses to emotional faces in anxious and depressed adolescents. Neuroimage, 53, 952–961.PubMedGoogle Scholar
  94. Laucht, M., Treutlein, J., Blomeyer, D., Buchmann, A. F., Schmid, B., Becker, K., et al. (2009). Interaction between the 5-HTTLPR serotonin transporter polymorphism and environmental adversity for mood and anxiety psychopathology: Evidence from a high-risk community sample of young adults. International Journal of Neuropsychopharmacology, 12, 737–747.PubMedGoogle Scholar
  95. Lengua, L. J., West, S. G., & Sandler, I. N. (1998). Temperament as a predictor of symptomatology in children: Addressing contamination of measures. Child Development, 69, 164–181.PubMedGoogle Scholar
  96. Lesch, K. P., Bengel, D., Heils, A., Sabol, S. Z., Greenberg, B. D., Petri, S., et al. (1996). Association of anxiety-related traits with a polymorphism in the serotonin transporter gene regulatory region. Science, 274, 1527–1531.PubMedGoogle Scholar
  97. Leung, P. W., & Poon, M. W. (2001). Dysfunctional schemas and cognitive distortions in psychopathology: A test of the specificity hypothesis. Journal of Child Psychology and Psychiatry, 42, 755–765.PubMedGoogle Scholar
  98. Lewinsohn, P. M., Rohde, P., Klein, D. N., & Seeley, J. R. (1999). Natural course of adolescent major depressive disorder: I. Continuity into young adulthood. Journal of the American Academy of Child & Adolescent Psychiatry, 38, 56–63.Google Scholar
  99. Lewinsohn, P. M., Rohde, P., Seeley, J. R., & Fischer, S. A. (1993). Age-cohort changes in the lifetime occurrence of depression and other mental disorders. Journal of Abnormal Psychology, 102, 110–120.PubMedGoogle Scholar
  100. Lewinsohn, P. M., Solomon, A., Seeley, J. R., & Zeiss, A. (2000). Clinical implications of “subthreshold” depressive symptoms. Journal of Abnormal Psychology, 109, 345–351.PubMedGoogle Scholar
  101. Lonigan, C. J., & Vasey, M. W. (2009). Negative affectivity, effortful control, and attention to threat-relevant stimuli. Journal of Abnormal Child Psychology, 37, 387–399.PubMedGoogle Scholar
  102. Lonigan, C. J., Vasey, M. W., Phillips, B. M., & Hazen, R. A. (2004). Temperament, anxiety, and the processing of threat-relevant stimuli. Journal of Clinical Child and Adolescent Psychology, 33, 8–20.PubMedGoogle Scholar
  103. Lopez-Duran, N. L., Kovacs, M., & George, C. J. (2009). Hypothalamic-pituitary-adrenal axis dysregulation in depressed children and adolescents: A meta-analysis. Psychoneuroendocrinology, 34, 1272–1283.PubMedGoogle Scholar
  104. Lotrich, F. E., & Pollock, B. G. (2004). Meta-analysis of serotonin transporter polymorphisms and affective disorders. Psychiatric Genetics, 14, 121–129.PubMedGoogle Scholar
  105. MacMillan, S., Szeszko, P. R., Moore, G. J., Madden, R., Lorch, E., Ivey, J., et al. (2003). Increased amygdala: Hippocampal volume ratios associated with severity of anxiety in pediatric major depression. Journal of Child and Adolescent Psychopharmacology, 13, 65–73.PubMedGoogle Scholar
  106. Mantovani, A., Lisanby, S. H., Pieraccini, F., Ulivelli, M., Castrogiovanni, P., & Rossi, S. (2007). Repetitive transcranial magnetic stimulation (rTMS) in the treatment of panic disorder (PD) with comorbid major depression. Journal of Affective Disorders, 102, 277–280.PubMedGoogle Scholar
  107. Mazza, J. J., Abbott, R. D., Fleming, C. B., Harachi, T. W., Cortes, R. C., Park, J., et al. (2009). Early predictors of adolescent depression: A 7-year longitudinal study. Journal of Early Adolescence, 29, 664–692.Google Scholar
  108. McKinnon, M. C., Yucel, K., Nazarov, A., & MacQueen, G. M. (2009). A meta-analysis examining clinical predictors of hippocampal volume in patients with major depressive disorder. Journal of Psychiatry & Neuroscience, 34, 41–54.Google Scholar
  109. Merikangas, K. R., Risch, N. J., & Weissman, M. M. (1994). Comorbidity and co-transmission of alcoholism, anxiety and depression. Psychological Medicine, 24, 69–80.PubMedGoogle Scholar
  110. Merikangas, K. R., Swendsen, J. D., Preisig, M. A., & Chazan, R. Z. (1998). Psychopathology and temperament in parents and offspring: Results of a family study. Journal of Affective Disorders, 51, 63–74.PubMedGoogle Scholar
  111. Merikangas, K. R., Zhang, H., Avenevoli, S., Acharyya, S., Neuenschwander, M., & Angst, J. (2003). Longitudinal trajectories of depression and anxiety in a prospective community study. Archives of General Psychiatry, 60, 993–1000.PubMedGoogle Scholar
  112. Micco, J. A., Henin, A., Mick, E., Kim, S., Hopkins, C. A., Biederman, J., et al. (2009). Anxiety and depressive disorders in offspring at high risk for anxiety: A meta-analysis. Journal of Anxiety Disorders, 23, 1158–1164.PubMedGoogle Scholar
  113. Milham, M. P., Nugent, A. C., Drevets, W. C., Dickstein, D. S., Leibenluft, E., Ernst, M., et al. (2005). Selective reduction in amygdala volume in pediatric anxiety disorders: A voxel-based morphometry investigation. Biological Psychiatry, 57, 961–966.PubMedGoogle Scholar
  114. Moffitt, T. E., Harrington, H., Caspi, A., Kim-Cohen, J., Goldberg, D., Gregory, A. M., et al. (2007). Depression and generalized anxiety disorder: Cumulative and sequential comorbidity in a birth cohort followed prospectivity to age 32 years. Archives of General Psychiatry, 64, 651–660.PubMedGoogle Scholar
  115. Muris, P., & Ollendick, T. H. (2005). The role of temperament in the etiology of child psychopathology. Clinical Child and Family Psychology Review, 8, 271–289.PubMedGoogle Scholar
  116. Muris, P., van der Pennen, E., Sigmond, R., & Mayer, B. (2008). Symptoms of anxiety, depression, and aggression in non-clinical children: Relationships with self-report and performance-based measures of attention and effortful control. Child Psychiatry and Human Development, 39, 455–467.PubMedGoogle Scholar
  117. Norton, P. J., Hayes, S. A., & Hope, D. A. (2004). Effects of a transdiagnostic group treatment for anxiety on secondary depression. Depression and Anxiety, 20, 198–202.PubMedGoogle Scholar
  118. O’Connor, T. G., Ben-Shlomo, Y., Heron, J., Golding, J., Adams, D., & Glover, V. (2005). Prenatal anxiety predicts individual differences in cortisol in pre-adolescent children. Biological Psychiatry, 58, 211–217.PubMedGoogle Scholar
  119. Olino, T. M., Klein, D. N., Lewinsohn, P. M., Rohde, P., & Seeley, J. R. (2008). Longitudinal associations between depressive and anxiety disorders: A comparison of two trait models. Psychological Medicine, 38, 353–363.PubMedGoogle Scholar
  120. Ollendick, T. H., Jarrett, M. A., Grills-Taquechel, A. E., Hovey, L. D., & Wolff, J. C. (2008). Comorbidity as a predictor and moderator of treatment outcome in youth with anxiety, affective, attention deficit/hyperactivity disorder, and oppositional/conduct disorders. Clinical Psychology Review, 28, 1447–1471.PubMedGoogle Scholar
  121. Otto, M., Pollock, M., Rosenbaum, J. F., Sachs, G. S., & Asher, R. H. (1994). Childhood history of anxiety in adults with panic disorder: Association with anxiety sensitivity and comorbidity. Harvard Review of Psychiatry, 1, 288–293.PubMedGoogle Scholar
  122. Perez-Edgar, K., Roberson-Nay, R., Hardin, M. G., Poeth, K., Guyer, A. E., Nelson, E., et al. (2007). Attention alters neural responses to evocative faces in behaviorally inhibited adolescents. Neuroimage, 35, 1538–1546.PubMedGoogle Scholar
  123. Pine, D. S., Cohen, P., & Brook, J. (2001). Adolescent fears as predictors of depression. Biological Psychiatry, 50, 721–724.PubMedGoogle Scholar
  124. Pine, D. S., Cohen, P., Gurley, D., Brook, J., & Ma, Y. (1998). The risk for early-adulthood anxiety and depressive disorders in adolescents with anxiety and depressive disorders. Archives of General Psychiatry, 55, 56–64.PubMedGoogle Scholar
  125. Pizzagalli, D. A., Nitschke, J. B., Oakes, T. R., Hendrick, A. M., Horras, K. A., Larson, C. L., et al. (2002). Brain electrical tomography in depression: The importance of symptom severity, anxiety, and melancholic features. Biological Psychiatry, 52, 73–85.PubMedGoogle Scholar
  126. Plomin, R., Asbury, K., & Dunn, J. (2001). Why are child­ren in the same family so different? Nonshared environment a decade later. Canadian Journal of Psychiatry, 46, 225–233.Google Scholar
  127. Poletti, M. (2009). Adolescent brain development and executive functions: A prefrontal framework for developmental psychopathologies. Clinical Neuropsychi­atry, 6, 155–165.Google Scholar
  128. Reiss, S., & McNally, R. J. (1985). Expectancy model of fear. In S. Reiss & R. R. Bootzin (Eds.), Theoretical issues in behavior therapy (pp. 107–121). San Diego: Academic Press.Google Scholar
  129. Reynolds, W. M., & Coats, K. I. (1986). A comparison of cognitive-behavioral therapy and relaxation training for the treatment of depression in adolescents. Journal of Consulting and Clinical Psychology, 54, 653–660.PubMedGoogle Scholar
  130. Rice, F., van den Bree, M. B. M., & Thapar, A. (2004). A population-based study of anxiety as a precursor for depression in childhood and adolescence. BMC Psychiatry, 4, 43.PubMedGoogle Scholar
  131. Risch, N., Herrell, R., Lehner, T., Liang, K. Y., Eaves, L., Hoh, J., et al. (2009). Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: A meta-analysis. Journal of the American Medical Association, 301, 2462–2471.PubMedGoogle Scholar
  132. Roberson-Nay, R., McClure, E. B., Monk, C. S., Nelson, E. E., Guyer, A. E., Fromm, S. J., et al. (2006). Increased amygdala activity during successful memory encoding in adolescent major depressive disorder: An FMRI study. Biological Psychiatry, 60, 966–973.PubMedGoogle Scholar
  133. Rosso, I. M., Cintron, C. M., Steingard, R. J., Renshaw, P. F., Young, A. D., & Yurgelun-Todd, D. A. (2005). Amygdala and hippocampus volumes in pediatric major depression. Biological Psychiatry, 57, 21–26.PubMedGoogle Scholar
  134. Rothbart, M. K., & Bates, J. E. (1998). Temperament. In W. Damon & N. Eisenberg (Eds.), Handbook of child psychology (Social, emotional, and personality development 5th ed., Vol. 3, pp. 105–176). New Jersey: Wiley.Google Scholar
  135. Schmidt, L. A., & Fox, N. A. (1998). Fear-potentiated startle responses in temperamentally different human infants. Developmental Psychobiology, 32, 113–120.PubMedGoogle Scholar
  136. Seckl, J. R., & Meaney, M. J. (2004). Glucocorticoid programming. In R. Yehuda & B. McEwen (Eds.), Biobehavioral stress response: Protective and damaging effects (pp. 63–84). New York: New York Academy of Sciences.Google Scholar
  137. Seligman, L. D., & Ollendick, T. H. (1998). Comorbidity of anxiety and depression in children and adolescents: An integrative review. Clinical Child and Family Psychology Review, 1, 125–144.PubMedGoogle Scholar
  138. Sen, S., Burmeister, M., & Ghosh, D. (2004). Meta-analysis of the association between a serotonin transporter promoter polymorphism (5-HTTLPR) and anxiety-related personality traits. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 127B, 85–89.Google Scholar
  139. Serretti, A., Cristina, S., Lilli, R., Cusin, C., Lattuada, E., Lorenzi, C., et al. (2002). Family-based association study of 5-HTTLPR, TPH, MAO-A, and DRD4 polymorphisms in mood disorders. American Journal of Medical Genetics, 114, 361–369.PubMedGoogle Scholar
  140. Sheikh, H. I., Hayden, E. P., Singh, S. M., Dougherty, L. R., Olino, T. M., Durbin, C. E., et al. (2008). An examination of the association between the 5-HTT promoter region polymorphism and depressogenic attributional styles in childhood. Personality and Individual Differences, 45, 425–428.PubMedGoogle Scholar
  141. Sheline, Y. I., Barch, D. M., Donnelly, J. M., Ollinger, J. M., Snyder, A. Z., & Mintun, M. A. (2001). Increased amygdala response to masked emotional faces in depressed subjects resolves with antidepressant treatment: An fMRI study. Biological Psychiatry, 50, 651–658.PubMedGoogle Scholar
  142. Siegle, G. J., Thompson, W., Carter, C. S., Steinhauer, S. R., & Thase, M. E. (2007). Increased amygdala and decreased dorsolateral prefrontal BOLD responses in unipolar depression: Related and independent features. Biological Psychiatry, 61, 198–209.PubMedGoogle Scholar
  143. Silberg, J. L., Rutter, M., & Eaves, L. (2001). Genetic and environmental influences on the temporal association between earlier anxiety and later depression in girls. Biological Psychiatry, 49, 1040–1049.PubMedGoogle Scholar
  144. Simonds, V. M., & Whiffen, V. E. (2003). Are gender differences in depression explained by gender differences in co-morbid anxiety? Journal of Affective Disorders, 77, 197–202.PubMedGoogle Scholar
  145. Stark, K. D., Reynolds, W. M., & Kaslow, K. J. (1987). A comparison of the relative efficacy of self-control therapy and a behavioral problem-solving therapy for depression in children. Journal of Abnormal Child Psychology, 15, 91–113.PubMedGoogle Scholar
  146. Starr, L. R., & Davila, J. (2008). Differentiating interpersonal correlates of depressive symptoms and social anxiety in adolescence: Implications for models of comorbidity. Journal of Clinical Child & Adolescent Psychology, 37, 337–349.Google Scholar
  147. Suveg, C., Hudson, J. L., Brewer, G., Flannery-Schroeder, E., Gosch, E., & Kendall, P. C. (2009). Cognitive-behavioral therapy for anxiety-disordered youth: Secondary outcomes from a randomized clinical trial evaluating child and family modalities. Journal of Anxiety Disorders, 23, 341–349.PubMedGoogle Scholar
  148. Taghavi, M. R., Neshat-Doost, H. T., Moradi, A. R., Yule, W., & Dalgleish, T. (1999). Biases in visual attention in children and adolescents with clinical anxiety and mixed anxiety-depression. Journal of Abnormal Child Psychology, 27, 215–223.PubMedGoogle Scholar
  149. Thapar, A., & McGuffin, P. (1995). Are anxiety symptoms in childhood heritable? Journal of Child Psychology and Psychiatry, 36, 439–447.PubMedGoogle Scholar
  150. Thapar, A., & McGuffin, P. (1997). Anxiety and depressive symptoms in childhood – a genetic study of comorbidity. Journal of Child Psychology and Psychiatry, 38, 651–656.PubMedGoogle Scholar
  151. Thomas, K. M., Drevets, W. C., Dahl, R. E., Ryan, N. D., Birmaher, B., Eccard, C. H., et al. (2001). Amygdala response to fearful faces in anxious and depressed children. Archives of General Psychiatry, 58, 1057–1063.PubMedGoogle Scholar
  152. Topolski, T. D., Hewitt, J. K., Eaves, L., Meyer, J. M., Silberg, J. L., Simonoff, E., et al. (1999). Genetic and environmental influences on ratings of manifest anxiety by parents and children. Journal of Anxiety Disorders, 13, 371–397.PubMedGoogle Scholar
  153. Trosper, S. E., Buzzella, B. A., Bennett, S. M., & Ehrenreich, J. T. (2009). Emotion regulation in youth with emotional disorders: Implications for a unified treatment approach. Clinical Child and Family Psychology Review, 12, 234–254.PubMedGoogle Scholar
  154. Tugade, M. M., & Fredrickson, B. L. (2004). Resilient individuals use positive emotions to bounce back from negative emotional experiences. Journal of Personality and Social Psychology, 86, 320–333.PubMedGoogle Scholar
  155. Turner, S. M., Beidel, D. C., & Costello, A. (1987). Psychopathology in the offspring of anxiety disorders patients. Journal of Consulting and Clinical Psychology, 55, 229–235.PubMedGoogle Scholar
  156. Uher, R., & McGuffin, P. (2008). The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: Review and methodological analysis. Molecular Psychiatry, 13, 131–146.PubMedGoogle Scholar
  157. Van den Bergh, B. R., Van Calster, B., Smits, T., Van Huffel, S., & Lagae, L. (2008). Antenatal maternal anxiety is related to HPA-axis dysregulation and self-reported depressive symptoms in adolescence: A prospective study on the fetal origins of depressed mood. Neuropsychopharmacology, 33, 536–545.PubMedGoogle Scholar
  158. Verduin, T. L., & Kendall, P. C. (2003). Differential occurrence of comorbidity within childhood anxiety disorders. Journal of Clinical Child and Adolescent Psychology, 32, 290–295.PubMedGoogle Scholar
  159. Verhagen, M., van der Meij, A., Janzing, J. G., Arias-Vasquez, A., Buitelaar, J. K., & Franke, B. (2009). Effect of the 5-HTTLPR polymorphism in the serotonin transporter gene on major depressive disorder and related comorbid disorders. Psychiatric Genetics, 19, 39–44.PubMedGoogle Scholar
  160. Walkup, J. T., Albano, A. M., Piacentini, J., Birmaher, B., Compton, S. N., Sherrill, J. T., et al. (2008). Cognitive behavioral therapy, sertraline, or a combination in childhood anxiety. New England Journal of Medicine, 359, 2753–2766.PubMedGoogle Scholar
  161. Warner, V., Wickramaratne, P., & Weissman, M. M. (2008). The role of fear and anxiety in the familial risk for major depression: A three-generation study. Psychological Medicine, 38, 1543–1556.PubMedGoogle Scholar
  162. Waters, A. M., Craske, M. G., Bergman, R. L., & Treanor, M. (2008). Threat interpretation bias as a vulnerability factor in childhood anxiety disorders. Behaviour Research and Therapy, 46, 39–47.PubMedGoogle Scholar
  163. Weissman, M. M., Pilowsky, D. J., Wickramaratne, P. J., Talati, A., Wisniewski, S. R., Fava, M., et al. (2006). Remissions in maternal depression and child psychopathology: A STAR*D-child report. Journal of the American Medical Association, 295, 1389–1398.PubMedGoogle Scholar
  164. Weissman, M. M., Wickramaratne, P., Nomura, Y., Warner, V., Pilowsky, D., & Verdeli, H. (2006). Offspring of depressed parents: 20 years later. American Journal of Psychiatry, 163, 1001–1008.PubMedGoogle Scholar
  165. Weissman, M. M., Wickramaratne, P., Nomura, Y., Warner, V., Verdeli, H., Pilowsky, D. J., et al. (2005). Families at high and low risk for depression: A 3-generation study. Archives of General Psychiatry, 62, 29–36.PubMedGoogle Scholar
  166. Weissman, M. M., Wolk, S., Goldstein, R. B., Moreau, D., Adams, P., Greenwald, S., et al. (1999). Depressed adolescents grown up. Journal of the American Medical Association, 281, 1707–1713.PubMedGoogle Scholar
  167. Wittchen, H.-U., Beesdo, K., Bittner, A., & Goodwin, R. D. (2003). Depressive episodes – Evidence for a causal role of primary anxiety disorders? European Psychiatry, 18, 384–393.PubMedGoogle Scholar
  168. Wittchen, H.-U., & Fehm, L. (2003). Epidemiology and natural course of social fears and social phobia. Acta Psychiatrica Scandinavica, 108, 4–18.Google Scholar
  169. Wittchen, H.-U., Kessler, R. C., Pfister, H., & Lieb, M. (2000). Why do people with anxiety disorders become depressed? A prospective-longitudinal community study. Acta Psychiatrica Scandinavica, 102, 14–23.Google Scholar
  170. Wray, N. R., Birley, A. J., Sullivan, P. F., Visscher, P. M., & Martin, N. G. (2007). Genetic and phenotypic stability of measures of neuroticism over 22 years. Twin Research and Human Genetics, 10, 695–702.PubMedGoogle Scholar
  171. Young, J. F., Mufson, L., & Davies, M. (2006). Impact of comorbid anxiety in an effectiveness study of interpersonal psychotherapy for depressed adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 45, 904–912.PubMedGoogle Scholar
  172. Yurgelun-Todd, D. A., Killgore, W. D., & Cintron, C. B. (2003). Cognitive correlates of medial temporal lobe development across adolescence: A magnetic resonance imaging study. Perceptual and Motor Skills, 96, 3–17.PubMedGoogle Scholar
  173. Zavos, H. M., Rijsdijk, F. V., Gregory, A. M., & Eley, T. C. (2010). Genetic influences on the cognitive biases associated with anxiety and depression symptoms in adolescents. Journal of Affective Disorders, 124, 45–53. PubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Margaret S. Andover
    • 1
  • Genevieve N. Izzo
  • Chris A. Kelly
  1. 1.Department of PsychologyFordham UniversityBronxUSA

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