Quantification of Systemic Interference in Optical Topography Data during Frontal Lobe and Motor Cortex Activation: An Independent Component Analysis

  • Sundeep Patel
  • Takusige Katura
  • Atsushi Maki
  • Ilias TachtsidisEmail author
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 701)


Functional near-infrared optical topography (OT) is used to non-invasively measure the changes in oxygenated and deoxygenated haemoglobin (Δ[HbO2], Δ[HHb]) and hence investigate the brain haemodynamic changes, which occur in response to functional activation at specific regions of the cerebral cortex. However, when analysing functionalOT data the task-related systemic changes should be taken into account.Here we used an independent component analysis (ICA) method on the OT [HbO2] signal, to determine the task-related independent components and then compared them with the systemic measurements (blood pressure, heart rate, scalp blood flow) to assess whether the components are due to systemic noise or neuronal activation. This analysis can therefore extract the true OT haemodynamic neuronal response and hence discriminate between regional activated cortical areas and global haemodynamic changes.


Independent Component Analysis Independent Component Analysis Haemodynamic Change Mean Blood Pressure Diffuse Optical Imaging 
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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Sundeep Patel
    • 1
  • Takusige Katura
    • 2
  • Atsushi Maki
    • 2
  • Ilias Tachtsidis
    • 1
    Email author
  1. 1.Biomedical Optics Research Laboratory, Department of Medical Physics and BioengineeringUniversity College LondonLondonUK
  2. 2.Advanced Research LaboratoryHitachi LtdHatoyamaJapan

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