Oxygen Transport to Tissue XXXII pp 313-318 | Cite as
A Heat-Shock Protein Co-Inducer Treatment Improves Behavioral Performance in Rats Exposed to Hypoxia
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Abstract
We investigated the effect of a heat-shock protein co-inducer, arimoclomol (CytRx, LA, CA), on hypoxia-adaptive responses using a ratmodel of simulated altitude exposure (hypobaric hypoxia).Cognitive functionwasmeasured using a T-maze and an object recognition test.Motor functionwasmeasured using an inclined-screen test and an adhesion removal test. Immunohistochemical analyses were assessed in brain for heat-shock protein 70 (HSP 70), intercellular adhesion molecule 1 (ICAM- 1) and apoptosis (TUNEL staining). Results show that both cognitive and motor performanceswere improved in rats treated with arimoclomol during hypoxic exposure; the hypoxia-induced expression of HSP70 and ICAM-1, and TUNEL-positive cells were reduced in brainwith the treatment.Our data suggest that the arimoclomol treatment reduces the hypoxia-induced stress in brain tissue, and also improves the behavioral performance in rats during hypoxic adaptation.
Keywords
TUNEL Staining Hypobaric Hypoxia Hypoxic Exposure Object Recognition Test Sticky TapePreview
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