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Wound Healing in Diabetes: Hemorheological and Microcirculatory Aspects

  • Giuseppe CiccoEmail author
  • Francesco Giorgino
  • Sebastiano Cicco
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 701)

Abstract

Diabetes is associated with many hemorheological alterations. The decrease of RBC deformability, increase of aggregability, vasoconstriction, increase of blood viscosity and decrease of oxygen supply have a significant effect on wound healing, such as in foot ulcers. Basically, there is endothelial dysfunction and alteration of permeability; these impair wound healing in diabetic patients. Microcirculation still functions and there is blood flow, even when there is a decrease in vessel diameter, without anatomical lesions in vessel walls. It is necessary to maintain a good oxygen supply. Analyzing microcirculation and hemorheology in diabetes and considering methodologies to treat diabetic foot ulcers (e.g., hyperbaric oxygen therapy, laser, and vacuum) may help in the treatment of patient pathologies.

Keywords

Negative Pressure Wound Therapy Peripheral Occlusive Arterial Disease Hyperbaric Oxygen Therapy Blood Rheology Negative Pressure Therapy 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Giuseppe Cicco
    • 1
    Email author
  • Francesco Giorgino
    • 2
  • Sebastiano Cicco
    • 1
  1. 1.Hemorheology and Microcirculation Research UnitUniversity of BariBariItaly
  2. 2.Section of Internal Medicine, Endocrinology, Andrology and Metabolic Diseases, Department of Emergency and Organ TransplantationUniversity of BariBariItaly

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