Impaired Cerebral Autoregulation Using Near-Infrared Spectroscopy and Its Relation to Clinical Outcomes in Premature Infants
The concordance between the change in the Mean Arterial Blood Pressure (MABP) and the Cerebral Blood Flow (CBF) is studied using the Correlation, Coherence and Partial Coherence methods in order to detect Impaired Cerebral Autoregulation in Neonates. The presence of impaired autoregulation is assessed by the use of the Critical Percentage of Recording Time (CPRT). The changes in CBF are reflected by the measurement of changes in cerebral intravascular oxygenation (HbD), regional cerebral oxygen saturation (rSO2), and cerebral tissue oxygenation (TOI), as measured by Near-Infrared Spectroscopy (NIRS) (INVOS4100 and NIRO300). The relation between impaired autoregulation and long term clinical outcomes in premature infants is studied.
KeywordsCerebral Blood Flow Premature Infant Mean Arterial Blood Pressure Cerebral Autoregulation Impaired Autoregulation
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- 1.Tsuji M, Saul J, du Plessis A et al (2000)Cerebral intravascular oxygenation correlates with mean arterial pressure in critically ill premature infants. Pediatric Review 106(4):625-632.Google Scholar
- 3.DeSmet D, Jacobs J.,Ameye L.,Vanderhaegen J,Naulaers Get al (2008) The Partial coherence method for assessment of impaired cerebral autoregulation using Near-Infrared Spectroscopy: potential and limitations. Proceedings ISOTT 2008, August 3-7, Sapporo, Japan, to appear.Google Scholar
- 4.Soul J, Hammer P, TsujiMet al (2007) Fluctuating pressure-passivity is common in the cerebral circulation of sick premature infants. Pediatric Research 61: 467-473.Google Scholar
- 10.Morren G, Lemmerling P, Van Huffel S et al (2001) Detection of autoregulation in the brain of premature infants using a novel subspace-based technique. Proceedings of 23rd International IEEE-EMBS Conference 2:2064-2067.Google Scholar