Impaired Cerebral Autoregulation Using Near-Infrared Spectroscopy and Its Relation to Clinical Outcomes in Premature Infants

  • Alexander Caicedo
  • Dominique De Smet
  • Joke Vanderhaegen
  • Gunnar Naulaers
  • Martin Wolf
  • Petra Lemmers
  • Frank Van Bel
  • Lieveke Ameye
  • Sabine Van Huffel
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 701)

Abstract

The concordance between the change in the Mean Arterial Blood Pressure (MABP) and the Cerebral Blood Flow (CBF) is studied using the Correlation, Coherence and Partial Coherence methods in order to detect Impaired Cerebral Autoregulation in Neonates. The presence of impaired autoregulation is assessed by the use of the Critical Percentage of Recording Time (CPRT). The changes in CBF are reflected by the measurement of changes in cerebral intravascular oxygenation (HbD), regional cerebral oxygen saturation (rSO2), and cerebral tissue oxygenation (TOI), as measured by Near-Infrared Spectroscopy (NIRS) (INVOS4100 and NIRO300). The relation between impaired autoregulation and long term clinical outcomes in premature infants is studied.

Keywords

Catheter Ischemia Coherence Hydrocephalus Acetazolamide 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Alexander Caicedo
    • 1
  • Dominique De Smet
    • 1
  • Joke Vanderhaegen
    • 2
  • Gunnar Naulaers
    • 2
  • Martin Wolf
    • 3
  • Petra Lemmers
    • 4
  • Frank Van Bel
    • 4
  • Lieveke Ameye
    • 1
  • Sabine Van Huffel
    • 1
  1. 1.ESAT/SCD, Dept. of Electrical EngineeringKatholieke Universiteit LeuvenLeuvenBelgium
  2. 2.Neonatal Intensive Care UnitUniversity Hospital Gasthuisberg, Katholieke Universiteit LeuvenLeuvenBelgium
  3. 3.Clinic of NeonatologyUniversity Hospital ZurichZurichSwitzerland
  4. 4.Department of NeonatologyUniversity Medical Center, Wilhelmina Children’s HospitalUtrechtThe Netherlands

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