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Analysis of the Changes in the Oxidation of Brain Tissue Cytochrome-c-Oxidase in Traumatic Brain Injury Patients during Hypercapnoea

A Broadband NIRS Study
  • Ilias TachtsidisEmail author
  • Martin M. Tisdall
  • Caroline Pritchard
  • Terence S. Leung
  • Arnab Ghosh
  • Clare E. Elwell
  • Martin Smith
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 701)

Abstract

Using broadband near-infrared spectroscopy (NIRS) and cerebral microdialysis (MD),we investigated cerebral cellularmetabolismand mitochondrial redox states, following hypercapnoea in 6 patients with traumatic brain injury (TBI). In all patients hypercapnoea increased intracranial pressure and cerebral blood flow velocity measuredwith transcranialDoppler.Despite the likely increase in cerebral oxygen delivery, we did not see an increase in the oxidation status of cytochrome-c-oxidase [oxCCO] in every patient. Analysis of the NIRS data demonstrated two patterns of the changes; Group A (n = 4) showed an increase in [oxCCO] of 0.34(± 0.34)µM and Group B (n = 2) a decrease of 0.40(± 0.41)µM. Although no obvious association was seen between the Δ[oxCCO] and the MD, measured changes in lactate and pyruvate concentrations. Furtherwork usingmodel informed data interpretationmay be helpful in understanding the multimodal signals acquired in this heterogeneous patient group.

Keywords

Traumatic Brain Injury Cerebral Blood Flow Velocity Pyruvate Concentration Cerebral Microdialysis Multimodal Signal 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Ilias Tachtsidis
    • 1
    Email author
  • Martin M. Tisdall
    • 2
  • Caroline Pritchard
    • 2
  • Terence S. Leung
    • 1
  • Arnab Ghosh
    • 2
  • Clare E. Elwell
    • 1
  • Martin Smith
    • 1
    • 2
  1. 1.Biomedical Optics Research Laboratory, Department of Medical Physics and BioengineeringUniversity College LondonLondonUK
  2. 2.Neurocritical Care Unit, TheNationalHospital for Neurology andNeurosurgeryUniversity College London HospitalsLondonUK

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