Oxygenation Status of Urogenital Tumors

  • Peter VaupelEmail author
  • Michael Hoeckel
  • Arnulf Mayer
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 701)


In malignant urogenital tumors, tissue oxygenation is compromised and very heterogeneous,with steep and fluctuating spatio-temporal oxygen gradients signaling a complex instability in tumor oxygenation (complex “4D-heterogeneity”). Tumor hypoxia is highly dynamic, and rapidly changing pO2 gradients may be key factors driving hypoxia-dependent adaptive processes leading to malignant progression. The grand median oxygen tension in malignant urogenital tumors is 7–11 mmHg. In contrast, benign leiomyomas of the uterus are severely, but uniformly, hypoxicwith only shallow oxygen gradients (“static hypoxia”). In these benign tumors, the median pO2 is 1 mmHg and signs of hypoxia-driven processes are missing.


Radiat Oncol Biol Phys Uterine Cervix Oxygenation Status None None Tumor Hypoxia 
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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Radiooncology and RadiotherapyUniversity Medical CenterMainzGermany
  2. 2.Department of GynaecologyLeipzigGermany

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