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Prokaryotic Antimicrobial Peptides pp 309–332Cite as

Class II Microcins

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Abstract

Class II microcins are 4.9- to 8.9-kDa polypeptides produced by and active against enterobacteria. They are classified into two subfamilies according to their structure and their gene cluster arrangement. While class IIa microcins undergo no posttranslational modification, class IIb microcins show a conserved C-terminal sequence that carries a salmochelin-like siderophore motif as a posttranslational modification. Aside from this C-terminal end, which is the signature of class IIb microcins, some sequence similarities can be observed within and between class II subclasses, suggesting the existence of common ancestors. Their mechanisms of action are still under investigation, but several class II microcins use inner membrane proteins as cellular targets, and some of them are membrane-active. Like group B colicins, many, if not all, class II microcins are TonB- and energy-dependent and use catecholate siderophore receptors for recognition/­translocation across the outer membrane. In that context, class IIb microcins are considered to have developed molecular mimicry to increase their affinity for their outer membrane receptors through their salmochelin-like posttranslational modification.

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Acknowledgements

We are grateful to Dominique Belin for the generous gifts of the E. coli manXYZ mutants.

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  1. CNRS, Muséum National d’Histoire Naturelle, UMR 7245, CP 54, 57 rue Cuvier, 75005, Paris, France

    Jean Peduzzi

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  1. Gaëlle Vassiliadis
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  2. Delphine Destoumieux-Garzón
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Correspondence to Jean Peduzzi .

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  1. Nantes-Atlantic Natl. College of Vet. Me, Food Sci. & Eng., ONIRIS, Nantes, France

    Djamel Drider

  2. Dépt. Régulations, Développement et, Diversité Moléculaire, Muséum National d'Histoire Naturelle, rue Cuvier 57, Paris, 75005, France

    Sylvie Rebuffat

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Vassiliadis, G., Destoumieux-Garzón, D., Peduzzi, J. (2011). Class II Microcins. In: Drider, D., Rebuffat, S. (eds) Prokaryotic Antimicrobial Peptides. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7692-5_16

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