Skip to main content
SpringerLink
Log in
Book cover

Lymphoma and Leukemia of the Nervous System pp 287–297Cite as

Neurological Complications of Hodgkin Lymphoma

  • Chapter
  • First Online:

  • 978 Accesses

Abstract

Hodgkin lymphoma (HL) is a cancer of the immune system that is typically characterized by the presence of Reed-Sternberg cells. Approximately 30% of all lymphomas are of Hodgkin type. Classical HL is the most common presentation (95% of all cases) and can be divided into four subtypes: lymphocyte predominance, nodular sclerosis, mixed cellularity, and lymphocyte depletion.

This is a preview of subscription content, log in via an institution.

Chapter
USD   29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD   129.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD   169.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD   169.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Learn about institutional subscriptions

References

  1. Jaffe ES, Lee Harris N, Stein H, Vardiman J (eds) (2001) Tumours of Haematopoietic and Lymphoid Tissues: pathology and genetics. WHO Classification of Tumours. IARC Press, Lyon

    Google Scholar 

  2. Tierney L, McPhee S, Papadakis M (eds) (1997) Current Medical Diagnosis and Treatment, 36th edn. Appleton & Lange, New York, NY

    Google Scholar 

  3. Murchison C (1870) Case of “lymphadenoma” of the lymphatic system, spleen, liver, lungs, heart, diaphragm, dura mater. Trans Pathol Soc Lond 21:372–389

    Google Scholar 

  4. Abate G, Corazzelli G, Ciarmiello A, Monfardini S (1997) Neurologic complications of Hodgkin’s disease: a case history. Ann Oncol 8:593–600

    Article  PubMed  CAS  Google Scholar 

  5. Sapozink MD, Kaplan HS (1983) Intracranial Hodgkin’s disease. A report of 12 cases and review of the literature. Cancer 52:1301–1307

    Article  PubMed  CAS  Google Scholar 

  6. Re D, Fuchs M, Schober T et al (2007) CNS Involvement in Hodgkin’s Lymphoma. J Clin Oncol 25:3181

    Google Scholar 

  7. Hirmiz K, Foyle A, Wilke D et al (2004) Intracranial presentation of systemic Hodgkin’s disease. Leuk Lymphoma 45:1667–1671

    Article  PubMed  Google Scholar 

  8. McFadzean RM, McIlwaine GG, McLellan D (1990) Hodgkin’s disease at the optic chiasm. J Clin Neuroophthalmol 10:248–254

    PubMed  CAS  Google Scholar 

  9. Sparling H, Adams R (1946) Primary Hodgkin’s sarcoma of the brain. Arch Pathol 42:338–344

    Google Scholar 

  10. Schircker J, Smith D (1955) Primary intracerebral Hodgkin’s disease. Cancer 8:629–633

    Article  Google Scholar 

  11. Burstein SD, Kernohan JW, Uihlein A (1963) Neoplasms of the reticuloendothelial system of the brain. Cancer 16:289–305

    Article  PubMed  CAS  Google Scholar 

  12. Cambier J, Boivin P, Girauld A et al (1973) Cerebral lesions in Hodgkin’s disease. Ann Med Interne (Paris) 124:65–74

    CAS  Google Scholar 

  13. Cuttner J, Meyer R, Huang Y (1979) Intracerebral involvement in Hodgkin’s disease: a report of 6 cases and review of the literature. Cancer 43:1497–1506

    Article  PubMed  CAS  Google Scholar 

  14. Gerstner ER, Abrey LE, Schiff D et al (2008) CNS Hodgkin lymphoma. Blood 112:1658–1661

    Article  PubMed  CAS  Google Scholar 

  15. Biagi J, MacKenzie RG, Lim MS et al (2000) Primary Hodgkin’s disease of the CNS in an immunocompetent patient: a case study and review of the literature. Neurooncol 2:239–243

    CAS  Google Scholar 

  16. Bender BL, Mayernik DG (1986) Hodgkin’s disease presenting with isolated craniospinal involvement. Cancer 58(8):1745–1748

    Article  PubMed  CAS  Google Scholar 

  17. Herrlinger U, Klingel K, Meyermann R et al (2000) Central nervous system Hodgkin’s lymphoma without systemic manifestation: case report and review of the literature. Acta Neuropathol 99:709–714

    Article  PubMed  CAS  Google Scholar 

  18. De Bruin ML, Dorresteijn LD, van’t Veer MB et al (2009) Increased risk of stroke and transient ischemic attack in 5-year survivors of Hodgkin lymphoma. J Natl Cancer Inst 101:928–937

    Article  PubMed  Google Scholar 

  19. Klein R, Mullges W, Bendszus M et al (1999) Primary intracerebral Hodgkin’s disease: report of a case with Epstein-Barr virus association and review of the literature. Am J Surg Pathol 23:477–481

    Article  PubMed  CAS  Google Scholar 

  20. Alexander FE, Jarrett RF, Lawrence D et al (2000) Risk factors for Hodgkin’s disease by Epstein-Barr virus (EBV) status: prior infection by EBV and other agents. Br J Cancer 82:1117–1121

    Article  PubMed  CAS  Google Scholar 

  21. Akyuz C, Yalcin B, Atahan IL et al (2005) Intracranial involvement in Hodgkin’s disease. Pediatr Hematol Oncol 22:589–596

    Article  PubMed  Google Scholar 

  22. Antonio G, Dahlstrom J, Chandran KN, O’Neil R (2000) Cerebellopontine angle Hodgkin’s disease. Australas Radiol 44:115–117

    Article  PubMed  CAS  Google Scholar 

  23. Nakayama H, Tokuuye K, Kagami Y et al (2000) Brain involvement in Hodgkin’s disease: case reports and review of the literature. Radiat Med 18:205–208

    PubMed  CAS  Google Scholar 

  24. Kalinka E, Robak T, Wrzesien-Kus A et al (2002) Diagnostic and therapeutic quandaries in primary manifestation of Hodgkin’s disease in the central nervous system. Ann Hematol 81:289–291

    Article  PubMed  CAS  Google Scholar 

  25. King DP, Richardson JS (1950) Hodgkin’s disease of the cerebellum. St Thomas Hosp Rep 6:273–275

    Google Scholar 

  26. Lascelles RG, Burston J (1962) Hodgkin’s disease presenting with symptoms of cranial nerve involvement. Arch Neurol 7:359–364

    Google Scholar 

  27. Litvak J, Leder MM, Kauvar AJ (1964) Hodgkin’s disease involving optic nerve and brain. J Neurosurg 21:798–801

    Article  PubMed  CAS  Google Scholar 

  28. Fratkin JD, Shammas HF, Miller SD (1978) Disseminated Hodgkin’s disease with bilateral orbital involvement. Arch Ophthalmol 96:102–104

    PubMed  CAS  Google Scholar 

  29. Sahjupaul R, Elisevich K, Allen L (1996) Hodgkin’s disease of the orbit with intracranial extension. Ophthalmic Surg Lasers 27:239–242

    Google Scholar 

  30. Kasner SE, Galetta SL, Vaughn DJ (1996) Cavernous sinus syndrome in Hodgkin’s disease. J Neuroophthalmol 16:204–207

    PubMed  CAS  Google Scholar 

  31. Turner ML, Boland OM, Parker AC, Ewing DJ (1993) Subclinical autonomic dysfunction in patients with Hodgkin’s disease and non-Hodgkin’s lymphoma. Br J Haematol 84:623–626

    Article  PubMed  CAS  Google Scholar 

  32. Citow JS, Rini B, Wollmann R, Macdonald RL (2001) Isolated, primary extranodal Hodgkin’s disease of the spine: case report. Neurosurgery 49:453–456; discussion 6–7

    PubMed  CAS  Google Scholar 

  33. Higgins SA, Peschel RE (1995) Hodgkin’s disease with spinal cord compression. A case report and a review of the literature. Cancer 75:94–98

    Article  PubMed  CAS  Google Scholar 

  34. Friedman N, Kim T, Panahon A (1976) Spinal cord compression in malignant lymphoma: treatment and results. Cancer 37:1485–1491

    Article  PubMed  CAS  Google Scholar 

  35. Orlowski EP, Hansen RM, Anderson T et al (1984) Hodgkin’s disease with leptomeningeal involvement. Report of a case with long survival. Cancer 53:1833–1835

    Article  PubMed  CAS  Google Scholar 

  36. Dillman R, Mueh J, Greco C, Green M (1980) Leptomeningeal Hodgkin’s disease. Ann Intern Med 92:714–715

    Google Scholar 

  37. Rabhi M, Ennibi K, Chaari J, Toloune F (2007) Hodgkin’s disease presenting with spinal cord compression. Rev Neurol (Paris) 163:1109–1112

    CAS  Google Scholar 

  38. Recht L (1995) Neurological complications of lymphoma. In: Wiley R (ed) Neurological Complications of Cancer. Marcel Dekker, New York, NY, pp 465–87

    Google Scholar 

  39. Cervantes F, Montserrat E, Rozman C (1979) Eosinophilic meningitis in Hodgkin’s disease. Ann Intern Med 91:930

    PubMed  CAS  Google Scholar 

  40. Patchell R, Perry MC (1981) Eosinophilic meningitis in Hodgkin disease. Neurology 31:887–8

    PubMed  CAS  Google Scholar 

  41. Lokich J, Galbo C (1981) Leptomeningeal lymphoma: perspectives on management. Cancer Treat Rev 8:103–110

    Article  PubMed  CAS  Google Scholar 

  42. Bunn PA Jr, Schein PS, Banks PM, DeVita VT Jr (1976) Central nervous system complications in patients with diffuse histiocytic and undifferentiated lymphoma: leukemia revisited. Blood 47:3–10

    PubMed  Google Scholar 

  43. Cravioto H, Feigin I (1959) Noninfectious granulomatous angiitis with a predilection for the nervous system. Neurology 9:599–609

    PubMed  CAS  Google Scholar 

  44. Yuen RW, Johnson PC (1996) Primary angiitis of the central nervous system associated with Hodgkin’s disease. Arch Pathol Lab Med 120:573–576

    PubMed  CAS  Google Scholar 

  45. Rosen CL, DePalma L, Morita A (2000) Primary angiitis of the central nervous system as a first presentation in Hodgkin’s disease: a case report and review of the literature. Neurosurgery 46:1504–1508; discussion 8–10

    Article  PubMed  CAS  Google Scholar 

  46. Inwards DJ, Piepgras DG, Lie JT et al (1991) Granulomatous angiitis of the spinal cord associated with Hodgkin’s disease. Cancer 68:1318–1322

    Article  PubMed  CAS  Google Scholar 

  47. Yoong MF, Blumbergs PC, North JB (1993) Primary (granulomatous) angiitis of the central nervous system with multiple aneurysms of spinal arteries. Case report. J Neurosurg 79:603–607

    Article  PubMed  CAS  Google Scholar 

  48. Roggerone S, Traverse-Glehen A, Derex L et al (2008) Recurrent cerebral venous thrombosis revealing paraneoplastic angiitis in Hodgkin’s lymphoma. J Neurooncol 89:195–198

    Article  PubMed  Google Scholar 

  49. Volmer T, Guarnaccia J, Harrington W et al (1993) Idiopathic granulomatous angiitis of the central nervous system: diagnositic challenges. Arch Neurol 50:925–930

    Google Scholar 

  50. Calabrese LH, Furlan AJ, Gragg LA, Ropos TJ (1992) Primary angiitis of the central nervous system: diagnostic criteria and clinical approach. Cleve Clin J Med 59:293–306

    PubMed  CAS  Google Scholar 

  51. Portegies P, Algra PR, Hollak CE et al (1991) Response to cytarabine in progressive multifocal leucoencephalopathy in AIDS. Lancet 337:680–1

    Article  PubMed  CAS  Google Scholar 

  52. Steiger MJ, Tarnesby G, Gabe S et al (1993) Successful outcome of progressive multifocal leukoencephalopathy with cytarabine and interferon. Ann Neurol 33:407–411

    Article  PubMed  CAS  Google Scholar 

  53. Shet AS, Saba N, Rausch D, Belzer M (2004) Intra-cranial lesions in a patient with Hodgkin lymphoma. Leuk Lymphoma 45:419–422

    Article  PubMed  Google Scholar 

  54. Mazur MH, Dolin R (1978) Herpes zoster at the NIH: a 20 year experience. Am J Med 65:738–744

    Article  PubMed  CAS  Google Scholar 

  55. Correale J, Monteverde DA, Bueri JA, Reich EG (1991) Peripheral nervous system and spinal cord involvement in lymphoma. Acta Neurol Scand 83:45–51

    Article  PubMed  CAS  Google Scholar 

  56. Guerreiro CA, Guerreiro MM (1984) Ocular herpes zoster and delayed cerebrovascular accident: report of a case. Arq Neuropsiquiatr 42:402–407

    PubMed  CAS  Google Scholar 

  57. Vickers SM, Niederhuber JE (1997) Hodgkin’s disease associated with neurologic paraneoplastic syndrome. South Med J 90:839–844

    Article  PubMed  CAS  Google Scholar 

  58. Cipriani D, Landonio G, Canepari C (1989) A case of Vogt-Koyanagi-Harada syndrome in a patient affected by Hodgkin’s disease. J Neurol 236:303–4

    Article  PubMed  CAS  Google Scholar 

  59. Arasaki K, Kwee IL, Nakada T (1987) Limbic lymphoma. Neuroradiology 29:389–392

    Article  PubMed  CAS  Google Scholar 

  60. Deodhare S, O’Connor P, Ghazarian D, Bilbao JM (1996) Paraneoplastic limbic encephalitis in Hodgkin’s disease. Can J Neurol Sci 23:138–140

    PubMed  CAS  Google Scholar 

  61. Grisold W, Drlicek M, Liszka-Setinek U, Wondrusch E (1995) Anti-tumour therapy in paraneoplastic neurological disease. Clin Neurol Neurosurg 97:106–111

    Article  PubMed  CAS  Google Scholar 

  62. Cehreli C, Payzin B, Undar B et al (1995) Paraneoplastic cerebellar degeneration in association with Hodgkin’s disease: a report of two cases. Acta Haematol 94:210–213

    Article  PubMed  CAS  Google Scholar 

  63. Hammack J, Kotanides H, Rosenblum MK, Posner JB (1992) Paraneoplastic cerebellar degeneration. II. Clinical and immunologic findings in 21 patients with Hodgkin’s disease. Neurology 42:1938–1943

    PubMed  CAS  Google Scholar 

  64. Cavo M, Zaccaria A, d’Alessandro R et al (1984) Hodgkin’s disease and subacute cerebellar degeneration. A case report and review of the literature. Nouv Rev Fr Hematol 26:197–199

    PubMed  CAS  Google Scholar 

  65. Graus F, Dalmau J, Valldeoriola F et al (1997) Immunological characterization of a neuronal antibody (anti-Tr) associated with paraneoplastic cerebellar degeneration and Hodgkin’s disease. J Neuroimmunol 74:55–61

    Article  PubMed  CAS  Google Scholar 

  66. Graus F, Gultekin SH, Ferrer I et al (1998) Localization of the neuronal antigen recognized by anti-Tr antibodies from patients with paraneoplastic cerebellar degeneration and Hodgkin’s disease in the rat nervous system. Acta Neuropathol 96:1–7

    Article  PubMed  CAS  Google Scholar 

  67. Arkenau HT, Gordon C, Murphy F, Cunningham D (2007) Paraneoplastic syndrome: subacute cerebellar degeneration in Hodgkin’s disease. Leuk Lymphoma 48:819–822

    Article  PubMed  Google Scholar 

  68. Ypma PF, Wijermans PW, Koppen H, Sillevis Smitt PA (2006) Paraneoplastic cerebellar degeneration preceding the diagnosis of Hodgkin’s lymphoma. Neth J Med 64:243–247

    PubMed  CAS  Google Scholar 

  69. Batchelor TT, Platten M, Palmer-Toy DE et al (1998) Chorea as a paraneoplastic complication of Hodgkin’s disease. J Neurooncol 36:185–190

    Article  PubMed  CAS  Google Scholar 

  70. Dansey RD, Hammond-Tooke GD, Lai K, Bezwoda WR (1988) Subacute myelopathy: an unusual paraneoplastic complication of Hodgkin’s disease. Med Pediatr Oncol 16:284–286

    Article  PubMed  CAS  Google Scholar 

  71. Lahrmann H, Albrecht G, Drlicek M et al (2001) Acquired neuromyotonia and peripheral neuropathy in a patient with Hodgkin’s disease. Muscle Nerve 24:834–838

    Article  PubMed  CAS  Google Scholar 

  72. Caress JB, Abend WK, Preston DC, Logigian EL (1997) A case of Hodgkin’s lymphoma producing neuromyotonia. Neurology 49:258–9

    PubMed  CAS  Google Scholar 

  73. Dropcho EJ (1998) Neurologic paraneoplastic syndromes. J Neurol Sci 153:264–278

    Article  PubMed  CAS  Google Scholar 

  74. O’Neill JH, Murray NM, Newsom-Davis J (1988) The Lambert-Eaton myasthenic syndrome. A review of 50 cases. Brain 111(Pt 3):577–596

    Article  PubMed  Google Scholar 

  75. Grimaldi LM, Martino G, Braghi S et al (1993) Heterogeneity of autoantibodies in stiff-man syndrome. Ann Neurol 34:57–64

    Article  PubMed  CAS  Google Scholar 

  76. Kay CL, Davies-Jones GA, Singal R, Winfield DA (1993) Paraneoplastic opsoclonus-myoclonus in Hodgkin’s disease. J Neurol Neurosurg Psychiatry 56:831–2

    Article  PubMed  CAS  Google Scholar 

  77. Carr I (1982) The Ophelia syndrome: memory loss in Hodgkin’s disease. Lancet 1:844–5

    Article  PubMed  CAS  Google Scholar 

  78. Pfliegler G, Posan E, Glaub D et al (1990) Hodgkin’s disease and memory loss: another case of the Ophelia syndrome. Br J Haematol 74:232

    Article  PubMed  CAS  Google Scholar 

Download references

Acknowledgment

MMM would like to thank Dr. Lawrence Recht for guidance during writing of the original version of this chapter for the first edition of Lymphoma of the Nervous System.

Author information

Authors and Affiliations

  1. Department of Neurology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA

    Elizabeth R. Gerstner

  2. Departments of Neurology and Neurosurgery, Medical School, Fred Hutchinson Cancer Research Center, University of Washington, Seattle, WA, USA

    Maciej M. Mrugala

Authors
  1. Elizabeth R. Gerstner
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Maciej M. Mrugala
    View author publications

    You can also search for this author in PubMed Google Scholar

Corresponding author

Correspondence to Elizabeth R. Gerstner .

Editor information

Editors and Affiliations

  1. , Stephen E. and Catherine Pappas Center f, Massachusetts General Hospital, Fruit St. 55, Boston, 02114, Massachusetts, USA

    Tracy Batchelor

  2. Dept. Neurology, Memorial Sloan-Kettering Cancer Center, York Ave. 1275, New York, 10021-6007, New York, USA

    Lisa M. DeAngelis

Rights and permissions

Reprints and permissions

Copyright information

© 2012 Springer Science+Business Media, LLC

About this chapter

Cite this chapter

Gerstner, E.R., Mrugala, M.M. (2012). Neurological Complications of Hodgkin Lymphoma. In: Batchelor, T., DeAngelis, L. (eds) Lymphoma and Leukemia of the Nervous System. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7668-0_17

Download citation

Publish with us

Policies and ethics

Search

Navigation