Gene Discovery by MMTV Mediated Insertional Mutagenesis

  • Annabel Vendel-Zwaagstra
  • John Hilkens


Transformation of a normal cell into a cancer cell requires sequential accumulation of several genetic changes that affect various collaborating signaling cascades mainly involved in cell proliferation, survival and development [46]. To develop novel specific therapeutic compounds for cancer treatment, identification of these cancer causing genes, and subsequently the oncogenic pathways in which these genes act, is of utmost importance. Although a great deal of insight in the cellular mechanisms that lead to cancer has been obtained, many key players are still unidentified. Retroviral insertional mutagenesis (IM) screens provide one of the most efficient tools to identify genes involved in tumorigenesis and from there the specific oncogenic pathways involved.


Mammary Gland Mammary Tumor Long Terminal Repeat Insertional Mutagenesis Mouse Mammary Tumor Virus 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Divisions of Molecular GeneticsThe Netherlands Cancer InstituteAmsterdamThe Netherlands

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