Abstract
Although the regimens are given for specific organisms, the major differentiation is between ulcers caused by yeast—for which amphotericin B is the drug of choice—or mold (most commonly Fusarium)—for which natamycin is generally the preferred agent.Voriconazole is also often effective for yeasts and molds.Mechanical debridement of superficial lesions removes necrotic tissue and may aid with antifungal medication penetration.Therapeutic penetrating keratoplasty should be considered for progressive disease or deep penetration to prevent development of endophthalmitis.
пRefer to Appendix 3 for activity spectrum of anti-fungal agents
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Notes
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φ Recommend consultation with infectious disease specialist
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φ Recommend consultation with infectious disease specialist
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δ Please see special note on fungal keratitis at beginning of the specific antifungal regimins
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φ Recommend consultation with infectious disease specialist
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φ Recommend consultation with infectious disease specialist
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Rhee, D.J., Colby, K.A., Sobrin, L., Rapuano, C.J. (2011). Antifungal Agentsп . In: Ophthalmologic Drug Guide. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7621-5_2
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