Implementation of HEA BeadChip System at Medical Centers: Providing Extended Matched Units and Eliminating Complex Workups for Patients
Medical centers have long appreciated the need for a reliable system to provide compatible blood for patients. The immediate need to provide antigen-negative blood usually entails getting units from blood providers which delays transfusion and increases cost. Most hospital transfusion services do not have full reference lab capabilities to resolve complex cases and are forced to send out patient samples. The focus of the institutions highlighted in this chapter is to meet the needs of their special patient populations, while some are also providing services to other area hospitals. All institutions were motivated to implement BeadChip™ technology to expand and manage the inventories of antigen-negative units, thereby reducing their dependence on blood centers for Ag (antigen) negative and rare donor units. The patient samples analyzed are complex workups of patients with multiple antibodies, multiple previous transfusions, or patients with a positive direct antiglobulin test. These are usually submitted to the reference laboratories within the hospital or from other area hospitals. Applying the BeadChip™ technology in the hospital can reduce turnaround time for providing phenotype-matched units for alloimmunized patients. The impact of implementing BeadChip™ technology on patient care and on laboratory operations is discussed.
KeywordsAlloimmunization Autoantibodies Blood group antigens Blood groups DNA testing DNA array
We acknowledge Carolyn Whitsett, MD, for her critical review of the manuscript. We also recognize BeadChip users for their contributions, and Ermelina Enriquez, BS, at BioArray’s mih laboratory, and members of the technical marketing team, Ruth Huang, BS, Kevin Trainer, BS, and Tasmia Shariff, BS, for data compilation.
- 2.Rios M, Hue-Roye K, Storry JR et al. (2000) Cell typing the sensitized transfusion-dependent patient. Ann Clin Lab Sci 4:379–386Google Scholar
- 11.Abumuhor IA, Klapper EB, Smith LE (2009) The value of maintaining special screened RBC inventory by molecular testing in a tertiary care hospital. Transfusion 49(Suppl):242A (A22-030H)Google Scholar
- 13.Castilho L, Credidio DC, Ribeiro K et al. (2009) Anti-Fy3 in sickle cell disease patients genotyped as FY*B-33/FY*B-33. Transfusion 49(Suppl):35A (S83-030K)Google Scholar
- 14.Klapper E, Zhang Y, Figueroa P, et al. (2010) Toward extended phenotype matching: a new operational paradigm for the transfusion service, Transfusion 50(3):536–546Google Scholar