Abstract
The preferred conditioning regimen should be capable of eliminating or reducing the tumor load from the malignant disorder, provide adequate immunosuppression to prevent graft rejection, and have manageable side effects or regimen-related toxicities. Traditionally, all allogeneic conditioning regimens were ablative, meaning that stem cell support was required in order to attain hematopoietic recovery of the bone marrow. More recently, there has been a trend in multiple patient populations to move toward reduced-intensity regimens (RIT), which are defined as any regimen that does not require stem cell support for hematopoietic recovery and results in low hematologic toxicity and mixed donor–recipient chimerism in a substantial proportion of patients in the early post-transplantation period.
Access this chapter
Tax calculation will be finalised at checkout
Purchases are for personal use only
References
Champlin, R., Khouri, I., Anderlini, P., De Lima, M., Hosing, C., McMannis, J., et al. (2003). Nonmyeloablative preparative regimens for allogeneic hematopoietic transplantation: Biology and current indications. Oncology, 17:94–100.
Chunduri, S., Dobogai, L.C., Peace, D., Saunthararajah, Y., Chen, H.Y., Mahmud, N., et al. (2006). Comparable kinetics of myeloablation between fludarabine/full-dose busulfan and fludarabine/melphalan conditioning regimens in allogeneic peripheral blood stem cell transplantation. Bone Marrow Transplant, 38:477–482.
Ciurea, S.O., Anderssen, B.S. (2009). Busulfan in hematopoietic stem cell transplantation. Biol Blood Marrow Transplant, 15:523–536.
Giralt, S., Ballen, K., Rizzo, D., Bacigalupo, A., Horowitz, M., Pasquini, M., et al. (2009). Reduced intensity conditioning regimen workshop: defining the dose spectrum. Report of a workshop convened by the Center for International Blood and Marrow Transplant Research. Biol Blood Marrow Transplant, 15:367–369.
Al-Ali, H., Cross, M., Lange, T., Freund, M., Dolken, G., Niederwieser, D., et al. (2009). Low-dose total body irradiation-based regimens as preparative regimens for allogeneic haematopoietic cell transplantation in acute myelogenous leukemia. Curr Opin Oncol, 21(Suppl 1), S17–S22.
Khouri, I. (2006). Reduced-intensity regimens in allogeneic stem-cell transplantation for non-Hodgkins lymphoma and chronic lymphocytic leukemia. Hematology Am Soc Hematol Educ Program, 390–397
Lekakis, L., de Padua Silva, L., de Lima, M. (2008). Novel preparative regimens in hematopoietic stem cell transplantation. Curr Pharm Design, 14:1923–1935.
Margolin, K., Synold, T., Longmate, J., Doroshow, J.H. (2001). Methodologic guidelines for the design of high dose chemotherapy regimens. Biol Blood Marrow Transplant, 7:414–432.
Author information
Authors and Affiliations
Editor information
Editors and Affiliations
Rights and permissions
Copyright information
© 2010 Springer Science+Business Media, LLC
About this chapter
Cite this chapter
Bubalo, J. (2010). Conditioning Regimens. In: Maziarz, R., Slater, S. (eds) Blood and Marrow Transplant Handbook. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7506-5_5
Download citation
DOI: https://doi.org/10.1007/978-1-4419-7506-5_5
Published:
Publisher Name: Springer, New York, NY
Print ISBN: 978-1-4419-7505-8
Online ISBN: 978-1-4419-7506-5
eBook Packages: MedicineMedicine (R0)