Some Basic Concepts from Population Genetics

Chapter
Part of the Statistics for Biology and Health book series (SBH)

Abstract

The study of allele frequencies and how they vary over time and over geographic regions has led to many discoveries concerning evolutionary history, migration, gene flow, and the correlation between allele frequencies and disease rates across populations. This chapter covers only a few concepts from population genetics, emphasizing those most relevant to gene mapping: allele frequency estimation, population substructure, Hardy-Weinberg Equilibrium (HWE) and Disequilibrium (HWD), which are frequently used in the analysis of genetic data. Other concepts, e.g., Linkage Disequilibrium and Linkage Equilibrium, will be introduced in later chapters as the need arises.

Keywords

Migration Albumin Anemia Stratification Defend 

Bibliography

  1. Ahrengot V, Eldon K (1952) Distribution of abo-mn and rh types among Eskimos in South-west Greenland. Nature 169:1065CrossRefGoogle Scholar
  2. Christensen K, Arnbjerg J, Andresen E (1985) Polymorphism of serum albumin in dog breeds and its relation to weight and leg length. Hereditas 102(2):219–223CrossRefGoogle Scholar
  3. Fabricius-Hansen V (1939) Blood groups and MN-types of Eskimos in East Greenland. The Journal of Immunology 36:523–530Google Scholar
  4. Knowler W, Williams R, Pettitt D, Steinberg A (1988) Gm3;5,13,14 and type 2 diabetes mellitus: an association in American Indians with genetic admixture. American Journal of Human Genetics 43(4):520–526Google Scholar
  5. Lange K (2002) Mathematical and Statistical Methods for Genetic Analysis, 2nd edn. Springer, New York, NYCrossRefMATHGoogle Scholar
  6. Rosner B (1994) Fundamentals of Biostatistics, 4th edn. Duxbury Press, Belmont MAGoogle Scholar

Copyright information

© Springer Science+Business Media. LLC 2011

Authors and Affiliations

  1. 1.Department of BiostatisticsHarvard UniversityBostonUSA

Personalised recommendations