Noise-Induced Hearing Loss: From Animal Models to Human Trials
Exposure to noise results in neural swelling, hair cell loss, and strial damage. Toxic-free radical accumulation also contributes to cell death in the inner ear. The type and extent of pathology and amount and permanence of hearing loss all vary with the level and duration of the insult as well as the dynamic level change. New data indicate that temporary changes in hearing are potentially much more harmful than previously believed. The potential for the use of free radical scavengers as therapeutic agents varies with the noise insult; new studies are essential for determining the potential to prevent the previously unknown long-term sequellae of noise insults that induce temporary changes in hearing. Evaluating the effect of noise on the human inner ear and the potential for protection using novel therapeutic agents presents multiple challenges.
KeywordsGlutathione Cysteine Corti Salvi Ebselen
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