Noise-Induced Hearing Loss: From Animal Models to Human Trials

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 730)

Abstract

Exposure to noise results in neural swelling, hair cell loss, and strial damage. Toxic-free radical accumulation also contributes to cell death in the inner ear. The type and extent of pathology and amount and permanence of hearing loss all vary with the level and duration of the insult as well as the dynamic level change. New data indicate that temporary changes in hearing are potentially much more harmful than previously believed. The potential for the use of free radical scavengers as therapeutic agents varies with the noise insult; new studies are essential for determining the potential to prevent the previously unknown long-term sequellae of noise insults that induce temporary changes in hearing. Evaluating the effect of noise on the human inner ear and the potential for protection using novel therapeutic agents presents multiple challenges.

Keywords

Glutathione Cysteine Corti Salvi Ebselen 

References

  1. Campbell KCM, Meech RP, Klemens JJ, Gerberi MT, Dyrstad SSW, Larsen DL, Mitchell DL, El-Azizi M, Verhulst SJ, Hughes LF (2007) Prevention of noise- and drug-induced hearing loss with d-methionine. Hear Res 226:92–103.PubMedCrossRefGoogle Scholar
  2. Canlon B, Borg E, Flock A (1988) Protection against noise trauma by pre-exposure to a low level acoustic stimulus. Hear Res 34:197–200.PubMedCrossRefGoogle Scholar
  3. Danial NN (2007) BCL-2 family proteins: Critical checkpoints of apoptotic cell death. Clin Cancer Res 13:7254–7263.PubMedCrossRefGoogle Scholar
  4. Davis RI, Qiu W, Hamernik RP (2009) Role of the kurtosis statistic in evaluating complex noise exposures for the protection of hearing. Ear Hear 30:628–634.PubMedCrossRefGoogle Scholar
  5. Duan M, Qiu J, Laurell G, Borg EG, Olofsson A (2002) Susceptibility to impulse noise trauma is different among species. Assoc Res Otolaryngol Abstr 25:104.Google Scholar
  6. Gao WY, Ding DL, Zheng XY, Ruan FM, Liu YJ (1992) A comparison of changes in the stereocilia between temporary and permanent hearing losses in acoustic trauma. Hear Res 62:27–41.PubMedCrossRefGoogle Scholar
  7. Hamernik RP, Ahroon WA, Patterson JH Jr, Qiu W (2002) Relations among early postexposure noise-induced threshold shifts and permanent threshold shifts in the chinchilla. J Acoust Soc Am 111:320–326.PubMedCrossRefGoogle Scholar
  8. Henderson D, Bielefeld EC, Harris KC, Hu BH (2006) The role of oxidative stress in noise-induced hearing loss. Ear Hear 27:1–19.PubMedCrossRefGoogle Scholar
  9. Henderson D, McFadden SL, Liu CC, Hight N, Zheng XY (1999) The role of antioxidants in protection from impulse noise. Ann NY Acad Sci 884:368–380.PubMedCrossRefGoogle Scholar
  10. Henderson D, Subramaniam M, Gratton MA, Saunders SS (1991) Impact noise: The importance of level, duration, and repetition rate. J Acoust Soc Am 89:1350–1357.PubMedCrossRefGoogle Scholar
  11. Jacono AA, Hu B, Kopke RD, Henderson D, Van De Water TR, Steinman HM (1998) Changes in cochlear antioxidant enzyme activity after sound conditioning and noise exposure in the chinchilla. Hear Res 117:31–38.PubMedCrossRefGoogle Scholar
  12. Kopke R, Bielefeld E, Liu J, Zheng J, Jackson R, Henderson D, Coleman JK (2005) Prevention of impulse noise-induced hearing loss with antioxidants. Acta Otolaryngol (Stockh) 125:235–243.CrossRefGoogle Scholar
  13. Kopke RD, Jackson RL, Coleman JKM, Liu J, Bielefeld EC, Balough BJ (2007) NAC for noise: From the bench top to the clinic. Hear Res 226:114–125.PubMedCrossRefGoogle Scholar
  14. Kujawa SG, Liberman MC (2006) Acceleration of age-related hearing loss by early noise exposure: evidence of a misspent youth. J Neurosci 26:2115–2123.PubMedCrossRefGoogle Scholar
  15. Kujawa SG, Liberman MC (2009) Adding insult to injury: Cochlear nerve degeneration after “temporary” noise-induced hearing loss. J Neurosci 29:14077–14085.PubMedCrossRefGoogle Scholar
  16. Le Prell CG, Hughes LF, Miller JM (2007a) Free radical scavengers vitamins A, C, and E plus magnesium reduce noise trauma. Free Radical Biol Med 42:1454–1463.CrossRefGoogle Scholar
  17. Le Prell CG, Yamashita D, Minami S, Yamasoba T, Miller JM (2007b) Mechanisms of noise-induced hearing loss indicate multiple methods of prevention. Hear Res 226:22–43.PubMedCrossRefGoogle Scholar
  18. Lynch ED, Kil J (2009) Development of ebselen, a glutathione peroxidase mimic, for the prevention and treatment of noise-induced hearing loss. Semin Hear 30:47–55.CrossRefGoogle Scholar
  19. Maruyama J, Miller JM, Ulfendahl M (2007) Effects of antioxidants on auditory nerve function and survival in deafened guinea pigs. Neurobiol Dis 25:309–318.PubMedCrossRefGoogle Scholar
  20. McCombe AW, Binnington J, Davis A, Spencer H (1995) Hearing loss and motorcyclists. J Laryngol Otol 109:599–604.PubMedGoogle Scholar
  21. McFadden SL, Henderson D, Shen YH (1997) Low-frequency ‘conditioning’ provides long-term protection from noise-induced threshold shifts in chinchillas. Hear Res 103:142–150.PubMedCrossRefGoogle Scholar
  22. Niu X, Canlon B (2002) Activation of tyrosine hydroxylase in the lateral efferent terminals by sound conditioning. Hearing Research 174:124–132.PubMedCrossRefGoogle Scholar
  23. Nordmann AS, Bohne BA, Harding GW (2000) Histopathological differences between temporary and permanent threshold shift. Hear Res 139:13–30.PubMedCrossRefGoogle Scholar
  24. Ohlemiller KK (2008) Recent findings and emerging questions in cochlear noise injury. Hear Res 245:5–17.PubMedCrossRefGoogle Scholar
  25. Ohlemiller KK, Wright JS, Dugan LL (1999) Early elevation of cochlear reactive oxygen species following noise exposure. Audiol Neurootol 4:229–236.PubMedCrossRefGoogle Scholar
  26. Ryan AF, Bennett TM, Woolf NK, Axelsson A (1994) Protection from noise-induced hearing loss by prior exposure to a nontraumatic stimulus: Role of the middle ear muscles. Hear Res 72:23–28.PubMedCrossRefGoogle Scholar
  27. Salvi RJ, Perry JW, Hamernik RP, Henderson D (1982) Relationships between cochlear pathologies and auditory nerve and behavioral responses following acoustic trauma. In: Hamernik RP, Henderson D, Salvi RJ (eds) New perspectives in noise-induced hearing loss. Raven Press, New York, pp 165–188.Google Scholar
  28. Spoendlin H (1971) Primary structural changes in the organ of Corti after acoustic overstimulation. Acta Otolaryngol (Stockh) 71:166–176.CrossRefGoogle Scholar
  29. Spoendlin H (1976) Anatomical changes following various noise exposures. In: Henderson D, Hamernik R, Dosanjh S, Mills JH (eds) Effects of noise on hearing. Raven Press, New York p 69–89.Google Scholar
  30. Wang Y, Hirose K, Liberman MC (2002) Dynamics of noise-induced cellular injury and repair in the mouse cochlea. J Assoc Res Otolaryngol 3:248–268.PubMedCrossRefGoogle Scholar
  31. Yamashita D, Jiang H-Y, Le Prell CG, Schacht J, Miller JM (2005) Post-exposure treatment attenuates noise-induced hearing loss. Neuroscience 134:633–642.PubMedCrossRefGoogle Scholar
  32. Yamashita D, Jiang H, Schacht J, Miller JM (2004) Delayed production of free radicals following noise exposure. Brain Res 1019:201–209.PubMedCrossRefGoogle Scholar
  33. Yamashita D, Minami SB, Kanzaki S, Ogawa K, Miller JM (2008) Bcl-2 genes regulate noise-induced hearing loss. J Neurosci Res 86:920–928.PubMedCrossRefGoogle Scholar
  34. Yamasoba T, Dolan DF (1998) The medial cochlear efferent system does not appear to contribute to the development of acquired resistance to acoustic trauma. Hear Res 120:143–151.PubMedCrossRefGoogle Scholar
  35. Zheng XY, Henderson D, McFadden SL, Hu BH (1997) The role of the cochlear efferent system in acquired resistance to noise-induced hearing loss. Hear Res 104:191–203.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.University of FloridaGainesvilleUSA

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