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Biologic Nanoparticles and Vascular Disease

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Atherosclerosis Disease Management

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Abstract

Sustained or repeating chronic infections have been linked to arterial calcification. Biologic nanoparticles (NPs) that propagate in culture have been isolated from calcified soft tissues. When inoculated into experimental animals, NPs appear to exacerbate the arterial response to injury, up to and including medial discontinuity and vascular occlusion. These NPs may be re-assembled proteins and microvesicles derived from mammalian cells and/or microorganisms.

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Authors and Affiliations

  1. Departments of Surgery and Physiology and Biomedical Engineering, Mayo Clinic, 4-62 Medical Science Building, 200 First Street Southwest, Rochester, MN, 55905, USA

    Virginia M. Miller

Authors
  1. Maria K. Schwartz
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  2. John C. Lieske
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  3. Virginia M. Miller
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Correspondence to Virginia M. Miller .

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Editors and Affiliations

  1. Biomedical Technologies, Inc., Denver, Colorado, USA

    Jasjit S. Suri

  2. Planet Space, Inc., Chicago, Illinois, USA

    Chirinjeev Kathuria

  3. , Department of Electronics, Politecnico di Torino, Torino, Italy

    Filippo Molinari

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Schwartz, M.K., Lieske, J.C., Miller, V.M. (2011). Biologic Nanoparticles and Vascular Disease. In: Suri, J., Kathuria, C., Molinari, F. (eds) Atherosclerosis Disease Management. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7222-4_24

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