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Biologic Nanoparticles and Vascular Disease

  • Maria K. Schwartz
  • John C. Lieske
  • Virginia M. MillerEmail author
Chapter

Abstract

Sustained or repeating chronic infections have been linked to arterial calcification. Biologic nanoparticles (NPs) that propagate in culture have been isolated from calcified soft tissues. When inoculated into experimental animals, NPs appear to exacerbate the arterial response to injury, up to and including medial discontinuity and vascular occlusion. These NPs may be re-assembled proteins and microvesicles derived from mammalian cells and/or microorganisms.

Keywords

Arterial calcification Calcium Hydroxyapatite Infection Inflammation 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Maria K. Schwartz
  • John C. Lieske
  • Virginia M. Miller
    • 1
    Email author
  1. 1.Departments of Surgery and Physiology and Biomedical EngineeringMayo ClinicRochesterUSA

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