Turning on and off the Immunological Switch: Immune Response Polarization and Its Control by IL-10 and STAT3
The innate and immunologic arms of host resistance to pathogenic infections use distinct patterns of cytokine production to direct appropriate tissue responses. This chapter discusses how this “Immunological Switch” is coordinated by distinct T helper cell lineages and how IL-10 and STAT3 signaling controls the inflammatory response. A particular emphasis is given to the role of IL-10 and STAT3 in tumor-associated immunosuppression, where the functional inhibition of either molecule results in acquiescence to proinflammatory and anti-tumor Th1 type immune responses.
KeywordsDendritic Cell Th17 Cell Experimental Autoimmune Encephalomyelitis Unphosphorylated STAT3 Helper Cell Lineage
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