From the “Delayed Allergy Reaction” to the “Immunologic Constant of Rejection”

  • Ena Wang
  • Francesco M. Marincola


This book collects salient observational data, derived predominantly from human studies, regarding the mechanism(s) of rejection in various pathologic conditions; the premise is that immune rejection, better defined as “immune-mediated, tissue-specific destruction” (TSD) (Wang et al. 2008), comprises a broad range of ­phenomena ranging from tumor regression, to clearance of pathogen through destruction of infected cells, autoimmunity, allograft rejection by the host and host vs. graft reactions. Like different hands can turn on or off a switch, distinct ­mechanisms can trigger TSD, however, a convergent pathway is ultimately observed when TSD occurs consisting of a dramatic switch from chronic to acute inflammation (Mantovani et al. 2008).


Chronic Obstructive Pulmonary Disease Interferon Regulatory Factor Allograft Rejection Acute Allograft Rejection Acute Inflammatory Process 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Infectious Disease and Immunogenetics Section (IDIS), Department of Transfusion Medicine, Clinical Center and Trans-NIH Center for Human Immunology (CHI)National Institutes of HealthBethesdaUSA

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