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Self-Feedback in Actin Polymerization

  • Anders E. Carlsson
Conference paper
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 736)

Abstract

Polymerization of actin, which is crucial for functions such as cell migration, membrane ruffling, cytokinesis, and endocytosis, must be tightly regulated in order to preserve an adequate supply of free actin monomers to respond to changing external conditions. The paper will describe mechanisms by which F-actin feeds back on its own assembly, thus regulating itself. I will present the experimental evidence for such feedback terms, discuss their use in current models of actin dynamics in cells, and present preliminary calculations for the role of feedback in transient endocytic actin patches. These calculations suggest a partial homeostasis of F-actin, in which the F-actin peak height depends only weakly on the actin filament nucleation rate.

Keywords

Actin Filament Actin Polymerization Fluorescence Recovery After Photobleaching Actin Patch Inhibit Actin Polymerization 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgment

This work was supported by the National Institutes of Health under Grant R01 GM086882.

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Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  1. 1.Department of PhysicsWashington UniversitySt. LouisUSA

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