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Advances in Systems Biology pp 293–310Cite as

Zooming in on Yeast Osmoadaptation

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Part of the book series: Advances in Experimental Medicine and Biology ((AEMB,volume 736))

Abstract

Saccharomyces cerevisiae is considered as a model organism for the investigation of cellular and molecular processes and gene regulation. Specifically, the response of S. cerevisiae to increase in osmolarity of the external medium (osmoadaptation) is a model adaptation process. The first mathematical model of volume changes in S. cerevisiae due to osmolarity has been proposed as early as 1983 by Schwartz and Diller (Cryobiology 20(5):542–552). Since then, both experimental and computational methods in biology have progressed dramatically. Especially in recent years, the study of response to hyperosmotic stress in S. cerevisiae by systems biology approaches has advanced rapidly. However, a holistic understanding of osmoadaptation combining environmental conditions, cellular preconditions, biophysical processes, molecular and biochemical network dynamics, has not yet been reached. Here, we review recent advances in the investigation of different aspects of osmoadaptation and discuss them with respect to an integrated view. This leads us to critically evaluate how to approach the goal of such an integrated view.

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Acknowledgements

EK is supported by UNICELLSYS (European Commission 7th Framework Programme: Contract No. 201142)

Author information

Authors and Affiliations

  1. Theoretical Biophysics, Humboldt-Universität zu Berlin, Invalidenstr. 42, D-10115, Berlin, Germany

    Clemens Kühn & Edda Klipp

Authors
  1. Clemens Kühn
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  2. Edda Klipp
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Correspondence to Edda Klipp .

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Editors and Affiliations

  1. School of Informatics, University of Edinburgh, Crichton Street 10, Edinburgh, EH89AB, UK

    Igor I. Goryanin

  2. School of Biological Sciences, University of Edinburgh, Mayfield Road, Edinburgh, EH93JR, UK

    Andrew B. Goryachev

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© 2012 Springer Science+Business Media, LLC

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Kühn, C., Klipp, E. (2012). Zooming in on Yeast Osmoadaptation. In: Goryanin, I.I., Goryachev, A.B. (eds) Advances in Systems Biology. Advances in Experimental Medicine and Biology, vol 736. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7210-1_17

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