Effects and Therapeutic Potential of Targeting Dysregulated Signaling Axes in Squamous Cell Carcinoma: Another Kinase of Transcription and Mammalian Target of Rapamycin

  • Cheryl Clark
  • Oleksandr Ekshyyan
  • Cherie-Ann O. Nathan


Head and neck squamous cell carcinoma (HNSCC) needs new approaches to treatment, as 500,000 new cases are seen worldwide annually, and recurrences and second primaries result in significant morbidity and poor survival. HNSCC is characterized by a persistent activation of the human v-akt murine thymoma viral oncogene homolog 1 (AKT)/mammalian target of rapamycin (mTOR) pathway that initiates a cascade of cellular events intrinsic to the carcinogenic process including cell survival, proliferation, cell cycle progression, cell growth, transcription and translation, angiogenesis, invasion, and metastasis. The AKT/mTOR pathway integrates a variety of signaling pathways involved in cell growth and division, and inhibitors of this pathway effectively starve the targeted cells.


Epidermal Growth Factor Receptor Esophageal Squamous Cell Carcinoma mTOR Inhibitor Tuberous Sclerosis Complex Epidermal Growth Factor Receptor Inhibitor 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Cheryl Clark
  • Oleksandr Ekshyyan
  • Cherie-Ann O. Nathan
    • 1
    • 2
  1. 1.Department of Otolaryngology-Head and Neck SurgeryLouisiana State University Health Sciences CenterShreveportUSA
  2. 2.Feist-Weiller Cancer CenterShreveportUSA

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