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Targeting UVB Mediated Signal Transduction Pathways for the Chemoprevention of Squamous Cell Carcinoma

  • G. Tim Bowden
  • David S. Alberts
Chapter

Abstract

The high incidence of skin cancer in the USA is directly related to solar radiation exposure. There is also a disturbing increase in the incidence of both nonmelanoma and melanoma skin cancers in the USA. There is evidence that the use of sunblocks or sunscreens is not totally effective in preventing skin cancer. Therefore, there is a need for new mechanism-based approaches to prevent solar radiation-induced skin cancers. Ultraviolet (UV) light can initiate skin tumor development through DNA damage and critical mutations, for instance in the p53 tumor suppressor gene. UV light can also promote the clonal expansion of these initiated cells through signal transduction pathways to give rise to benign tumors. Some of these signaling pathways mediate the downstream activation of the transcription factor complex, activator protein 1, which has been shown to play a functional role in UV induced skin carcinogenesis. Targeting of these signaling pathways using natural products and small molecule inhibitors is being explored for early chemoprevention of nonmelanoma skin cancer.

Keywords

HaCaT Cell Mouse Skin cAMP Response Element Binding Actinic Keratose Skin Carcinogenesis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology and Anatomy, Arizona Cancer Centre, University of Arizona, College of MedicineUniversity of ArizonaTucsonUSA
  2. 2.Arizona Cancer CenterUniversity of ArizonaTucsonUSA

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