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Proteomic Analysis of CNS Injury and Recovery

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Genomics, Proteomics, and the Nervous System

Part of the book series: Advances in Neurobiology ((NEUROBIOL,volume 2))

Abstract

Despite the enormous medical and economic consequences of traumatic injury to the central nervous system (CNS), little is known about the proteins involved in the resulting pathology. Major advances in the identification of such proteins have been made in recent years through application of differential proteome analysis. Such an approach has revealed a number of novel proteins as potential regulators of the degenerative and regenerative processes that take place in the mammalian brain and spinal cord after a traumatic insult. Some of these proteins may serve as diagnostic and prognostic markers to assess the severity of tissue damage. Comparative proteome analysis of regeneration-competent vs. regeneration-deficient systems are likely to provide new insights into the cellular signals that could be targeted for therapeutic intervention to increase the repair capacity of the human CNS.

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Abbreviations

2D PAGE:

Two-dimensional polyacrylamide gel electrophoresis

CNS:

Central nervous system

GFAP:

Glial fibrillary acidic protein

SCI:

Spinal cord injury

TBI:

Traumatic brain injury

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  1. Department of Biology, Northeastern University, 134 Mugar Life Sciences, 360 Huntington Avenue, Boston, MA, 02115, USA

    Günther K. H. Zupanc

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  1. Günther K. H. Zupanc
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  2. Marianne M. Zupanc
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Correspondence to Günther K. H. Zupanc .

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  1. Nathan S. Kline Institute for, Psychiatric Research, New York University, Old Orangeburg Road 140, Orangeburg, 10962, New York, USA

    James D Clelland

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Zupanc, G.K.H., Zupanc, M.M. (2011). Proteomic Analysis of CNS Injury and Recovery. In: Clelland, J. (eds) Genomics, Proteomics, and the Nervous System. Advances in Neurobiology, vol 2. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7197-5_20

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