Computer Dynamic Modeling of the Gene Network Controlling Intracellular Cholesterol Homeostasis
An adequate computer dynamic model of the gene network regulating cholesterol homeostasis that would allow for investigation of its components (RNAs, proteins, their complexes, metabolites, etc.) is demanded for a deeper insight and a more integral understanding of this intricate gene network, study of its various operation modes and the underlying mechanisms, assessment of effects of mutations on its operation, and choosing of the optimal strategies for influencing this system while solving particular problems, for example, therapeutic. In this work, a computer dynamic model of operation of the gene network controlling intracellular cholesterol homeostasis, regulation of its synthesis in the cell, and intake of the blood plasma cholesterol is constructed. The model is described in terms of elementary processes—biochemical reactions—and is fitted to the relevant published experimental data The optimal set of model’s parameters is determined. The results obtained are compared with the corresponding experimental data.
Key wordscomputer dynamic modeling gene network cholesterol biosynthesis homeostasis
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