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Computer Dynamic Modeling of the Gene Network Controlling Intracellular Cholesterol Homeostasis

  • A. V. Ratushny
  • E. V. Ignatieva
  • V. A. Likhoshvai

Abstract

An adequate computer dynamic model of the gene network regulating cholesterol homeostasis that would allow for investigation of its components (RNAs, proteins, their complexes, metabolites, etc.) is demanded for a deeper insight and a more integral understanding of this intricate gene network, study of its various operation modes and the underlying mechanisms, assessment of effects of mutations on its operation, and choosing of the optimal strategies for influencing this system while solving particular problems, for example, therapeutic. In this work, a computer dynamic model of operation of the gene network controlling intracellular cholesterol homeostasis, regulation of its synthesis in the cell, and intake of the blood plasma cholesterol is constructed. The model is described in terms of elementary processes—biochemical reactions—and is fitted to the relevant published experimental data The optimal set of model’s parameters is determined. The results obtained are compared with the corresponding experimental data.

Key words

computer dynamic modeling gene network cholesterol biosynthesis homeostasis 

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Copyright information

© Springer Science+Business Media New York 2004

Authors and Affiliations

  • A. V. Ratushny
    • 1
    • 2
  • E. V. Ignatieva
    • 1
    • 2
  • V. A. Likhoshvai
    • 1
    • 2
    • 3
  1. 1.Siberian Branch of the Russian Academy of SciencesInstitute of Cytology & GeneticsNovosibirskRussia
  2. 2.Novosibirsk State UniversityNovosibirskRussia
  3. 3.Ugra Research Institute of Information TechnologiesKhanty-MansyiskRussia

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