Skip to main content
SpringerLink
Log in

Painful Bladder Syndrome/Interstitial Cystitis in Women

  • Chapter
  • First Online:
Pain in Women

  • 1373 Accesses

Abstract

Painful bladder syndrome affects thousands, if not millions, of women. However, the syndrome is not completely understood and is often incorrectly diagnosed. Despite ongoing research, there is a lack of effective treatments and understanding of the pathogenesis of chronic pelvic and bladder pain syndromes. This condition can occur in men as well, although symptoms are often blamed on chronic prostatitis.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 99.00
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 129.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info
Hardcover Book
USD 219.99
Price excludes VAT (USA)
  • Durable hardcover edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

References

  1. Abrams P, Cardozo L, Fall M, Standardization Sub-committee of the International Continence Society, et al. The standardisation of terminology of lower urinary tract function: report from the Standardisation Sub-committee of the International Continence Society. Neurourol Urodyn. 2002;21(2):167–78.

    Article  PubMed  Google Scholar 

  2. van de Merwe JP, Nordling J, Bouchelouche P, et al. Diagnostic criteria, classification, and nomenclature for painful bladder syndrome/interstitial cystitis: an ESSIC proposal. Eur Urol. 2008;53(1):60–7.

    Article  PubMed  Google Scholar 

  3. Hanno P, Lin A, Nordling J, Nyberg L, van Ophoven A, Ueda T, Wein A, Bladder Pain Syndrome Committee of the International Consultation on Incontinence. Bladder Pain Syndrome Committee of the International Consultation on Incontinence. Neurourol Urodyn. 2010;29(1):191–8.

    Article  PubMed  Google Scholar 

  4. Rovner E, Propert KJ, Brensinger C, et al. Treatments used in women with interstitial cystitis: the interstitial cystitis data base study experience. The Interstitial Cystitis Data Base Study Group. Urology. 2000;20(56):940.

    Article  Google Scholar 

  5. Simon LJ, Landis JR, Erickson DR, Nyberg LM. The interstitial Cystitis Data Base Study: concepts and preliminary baseline descriptive statistics. Urology. 1997;49:64.

    Article  PubMed  CAS  Google Scholar 

  6. Koziol JA. Epidemiology of interstitial cystitis. Urol Clin North Am. 1994;21(1):7–20.

    PubMed  CAS  Google Scholar 

  7. Alagiri M, Chottiner S, Ratner V, Slade D, Hanno PM. Interstitial cystitis: unexplained associations with other chronic disease and pain syndromes. Urology. 1997;49(5A Suppl):52–7.

    Article  PubMed  CAS  Google Scholar 

  8. Weiss JM. Pelvic floor myofascial trigger points: manual therapy for interstitial cystitis and the urgency-frequency syndrome. J Urol. 2001;166:2226.

    Article  PubMed  CAS  Google Scholar 

  9. Peters KM, Kalinowski SE, Carrico DJ. Fact or fiction – is abuse prevalent in patients with interstitial cystitis? Results from a community survey and clinic population. J Urol. 2007;178:891.

    Article  PubMed  Google Scholar 

  10. Lilius HG, Oravisto KJ, Valtonen EJ. Origin of pain in interstitial cystitis. Effect of ultrasound treatment on the concomitant levator ani spasm syndrome. Scand J Urol Nephrol. 1973;7:15.

    Article  Google Scholar 

  11. Oyama IA, Rejba A, Lukban JC, et al. Modified Thiele massage as therapeutic intervention for female patients with interstitial cystitis and high-tone pelvic floor dysfunction. Urology. 2004;64:862.

    Article  PubMed  Google Scholar 

  12. Mayson BE, Teichman JM. The relationship between sexual abuse and interstitial cystitis/painful bladder syndrome. Curr Urol Rep. 2009;10:441.

    Article  PubMed  Google Scholar 

  13. Aloisi AM, Buonocore M, Merlo L, Galandra C, Sotgiu A, Bacchella L, Ungaretti M, Demartini L, Bonezzi C. Chronic pain therapy and hypothalamic-pituitary-adrenal axis impairment. Psychoneuroendocrinology. 2011;36(7):1032–9.

    Article  PubMed  CAS  Google Scholar 

  14. Dimitrakov J, Guthrie D. Genetics and phenotyping of urological chronic pelvic pain syndrome. J Urol. 2009;181:1550.

    Article  PubMed  Google Scholar 

  15. Talati A, Ponniah K, Strug LJ. Panic disorder, social anxiety disorder, and a possible medical syndrome previously linked to chromosome 13. Biol Psychiatry. 2008;63:594.

    Article  PubMed  CAS  Google Scholar 

  16. Wright LJ, Noonan C, Ahumada S. Psychological distress in twins with urological symptoms. Gen Hosp Psychiatry. 2010;32:262.

    Article  PubMed  Google Scholar 

  17. Peters KM, Killinger KA, Ibrahim IA. Childhood symptoms and events in women with interstitial cystitis/painful bladder syndrome. Urology. 2009;73:258.

    Article  PubMed  Google Scholar 

  18. Shorter B, Lesser M, Moldwin RM, Kushner L. Effect of comestibles on symptoms of interstitial cystitis. J Urol. 2007;178(1):145–52.

    Article  PubMed  Google Scholar 

  19. Rothrock NE, Lutgendorf SK, Kreder KJ, et al. Stress and symptoms in patients with interstitial cystitis: a life stress model. Urology. 2001;57:422.

    Article  PubMed  CAS  Google Scholar 

  20. Whitmore KE. Complementary and alternative therapies as treatment approaches for interstitial cystitis. Rev Urol. 2002;4 Suppl 1:S28–35.

    PubMed  Google Scholar 

  21. Kushner L, Moldwin RM. Efficiency of questionnaires used to screen for interstitial cystitis. J Urol. 2006;176(2):587–92.

    Article  PubMed  Google Scholar 

  22. Forrest JB, Moldwin R. Diagnostic options for early identification and management of interstitial cystitis/painful bladder syndrome. Int J Clin Pract. 2008;62(12):1926–34.

    Article  PubMed  CAS  Google Scholar 

  23. Waxman JA, Sulak PJ, Kuehl TJ. Cystoscopic findings consistent with interstitial cystitis in normal women undergoing tubal ligation. J Urol. 1998;160:1663.

    Article  PubMed  CAS  Google Scholar 

  24. Denson MA, Griebling TL, Cohen MB, Kreder KJ. Comparison of cystoscopic and histological findings in patients with suspected interstitial cystitis. J Urol. 2000;164:1908.

    Article  PubMed  CAS  Google Scholar 

  25. Ottem DP, Teichman JM. What is the value of cystoscopy with hydrodistension for interstitial cystitis? Urology. 2005;66(3):494–9.

    Article  PubMed  Google Scholar 

  26. Fitzgerald MP, Anderson RU, Potts J, et al. Randomized multicenter feasibility trial of myofascial physical therapy for the treatment of urological chronic pelvic pain syndromes. J Urol. 2009;182(2):570–80.

    Article  PubMed  Google Scholar 

  27. Chaiken DC, Blaivas JG, Blaivas ST. Behavioral therapy for the treatment of refractory interstitial cystitis. J Urol. 1993;149(6):1445.

    PubMed  CAS  Google Scholar 

  28. Fuentes CJP, Armijo-Olivo S, Magee DJ, Gross DP. Effects of exercise therapy on endogenous pain-relieving peptides in musculoskeletal pain: a systematic review. Clin J Pain. 2011;27(4):365–74.

    Article  Google Scholar 

  29. Dubin R, King-VanVlack C. The trajectory of chronic pain: can a community-based exercise/education program soften the ride? Pain Res Manag. 2010;15(6):361–8.

    PubMed  Google Scholar 

  30. Dimitrakov J, Kroenke K, Steers WD. Pharmacologic management of painful bladder syndrome/interstitial cystitis: a systematic review. Arch Intern Med. 2007;167(18):1922.

    Article  PubMed  CAS  Google Scholar 

  31. Davis EL, El Khoudary SL, Talbott EO. Safety and efficacy of the use of intravesical and oral pentosan polysulfate sodium for interstitial cystitis: a randomized double-blind clinical trial. J Urol. 2008;179(1):177–85.

    Article  PubMed  CAS  Google Scholar 

  32. Leite FM, Atallah AN, El Dib R, Grossmann E, Januzzi E, Andriolo RB, da Silva EM. Cyclobenzaprine for the treatment of myofascial pain in adults. Cochrane Database Syst Rev. 2009;8(3):CD006830.

    Google Scholar 

  33. Nickel JC, Payne CK, Forrest J, et al. The relationship among symptoms, sleep disturbances and quality of life in patients with interstitial cystitis. J Urol. 2009;181(6):2555–61.

    Article  PubMed  CAS  Google Scholar 

  34. Sasaki K, Smith CP, Chuang YC, et al. Oral gabapentin (neurontin) treatment of refractory genitourinary tract pain. Tech Urol. 2001;7(1):47–9.

    PubMed  CAS  Google Scholar 

  35. Phatak S, Foster Jr HE. The management of interstitial cystitis: an update. Nat Clin Pract Urol. 2006;3(1):45–53.

    Article  PubMed  Google Scholar 

  36. Foster Jr HE, Hanno PM, Nickel JC, Interstitial Cystitis Collaborative Research Network, et al. Effect of amitriptyline on symptoms in treatment naïve patients with interstitial cystitis/painful bladder syndrome. J Urol. 2010;183(5):1853–8.

    Article  PubMed  Google Scholar 

  37. Sant GR, Propert KJ, Hanno PM, et al. A pilot clinical trial of oral pentosan polysulfate and oral hydroxyzine in patients with interstitial cystitis. J Urol. 2003;170(3):810–5.

    Article  PubMed  CAS  Google Scholar 

  38. Seshadri P, Emerson L, Morales A. Cimetidine in the treatment of interstitial cystitis. Urology. 1994;44(4):614–6.

    Article  PubMed  CAS  Google Scholar 

  39. Thilagarajah R, Witherow RO, Walker MM. Oral cimetidine gives effective symptom relief in painful bladder disease: a prospective, randomized, double-blind placebo-controlled trial. BJU Int. 2001;87(3):207–12.

    Article  PubMed  CAS  Google Scholar 

  40. Nickel JC, Moldwin R, Lee S, et al. Intravesical alkalinized lidocaine (PSD597) offers sustained relief from symptoms of interstitial cystitis and painful bladder syndrome. BJU Int. 2009;103(7):910–8.

    Article  PubMed  CAS  Google Scholar 

  41. Parsons CL. Successful downregulation of bladder sensory nerves with combination of heparin and alkalinized lidocaine in patients with interstitial cystitis. Urology. 2005;65:45.

    Article  PubMed  Google Scholar 

  42. Moldwin RM, Evans RJ, Stanford EJ, Rosenberg MT. Rational approaches to the treatment of patients with interstitial cystitis. Urology. 2007;69(4 Suppl):73–81.

    Article  PubMed  Google Scholar 

  43. Dawson TE, Jamison J. Intravesical treatments for painful bladder syndrome/interstitial cystitis. Cochrane Database Syst Rev. 2007;17(4):CD006113.

    Google Scholar 

  44. Dmochowski R, Chapple C, Nitti VW, et al. Efficacy and safety of onabotulinumtoxinA for idiopathic overactive bladder: a double-blind, placebo controlled, randomized, dose ranging trial. J Urol. 2010;184:2416.

    Article  PubMed  CAS  Google Scholar 

  45. Smith CP, Radziszewski P, Borkowski A, et al. Botulinum toxin A has antinociceptive effects in treating interstitial cystitis. Urology. 2004;64:871.

    Article  PubMed  Google Scholar 

  46. Anger JT, Weinberg A, Suttorp MJ, et al. Outcomes of intravesical botulinum toxin for idiopathic overactive bladder symptoms: a systematic review of the literature. J Urol. 2010;183:2258.

    Article  PubMed  Google Scholar 

  47. Zhao J, Nordling J. Posterior tibial nerve stimulation in patients with intractable interstitial cystitis. BJU Int. 2004;94(1):101–4.

    Article  PubMed  Google Scholar 

  48. Zhao, J, Bai J, Zhou Y, Qi G, Du L. Posterior tibial nerve stimulation twice a week in patients with interstitial cystitis. Urology. 2008;71(6):1080–4.

    Article  PubMed  CAS  Google Scholar 

  49. Paszkiewicz EJ, Siegel SW, Kirkpatrick C, Hinkel B, Keeisha J, Kirkemo A. Sacral nerve stimulation in patients with chronic, intractable pelvic pain. Urology. 2001 Jun;57(6 Suppl 1):124.

    Article  PubMed  Google Scholar 

  50. Maher CF, Carey MP, Dwyer PL, Schluter PL. Percutaneous sacral nerve root neuromodulation for intractable interstitial cystitis. 2001;165(3):884–6.

    Article  PubMed  CAS  Google Scholar 

  51. Hwang P, Auclair B, Beechinor D, et al. Efficacy of pentosan polysulfate in the treatment of interstitial cystitis: a meta-analysis. Urology. 1997;50(1):39.

    Article  PubMed  Google Scholar 

  52. Nickel JC, Barkin J, Forrest J. Randomized, double-blind, dose-ranging study of pentosan polysulfate sodium for interstitial cystitis. Urology. 2005;65(4):654–8.

    PubMed  CAS  Google Scholar 

  53. Hohenfellner Surgical treatment. 1997 In Sant: Interstitial cystitis.

    Google Scholar 

  54. Goldstein HB, Safaeian P, Garrod K, et al. Depression, abuse and its relationship to interstitial cystitis. Int Urogynecol J Pelvic Floor Dysfunct. 2008;19(12):1683–6.

    PubMed  Google Scholar 

  55. Carrico DJ, Peters KM, Diokno AC. Guided imagery for women with interstitial cystitis: results of a prospective, randomized controlled pilot study. J Altern Complement Med. 2008;14(1):53–60.

    PubMed  Google Scholar 

  56. Rapkin AJ, Kames LD. The pain management approach to chronic pelvic pain. J Reprod Med. 1987;32(5):323–7.

    PubMed  Google Scholar 

  57. Karper WB. Exercise effects on interstitial cystitis: two case reports. Urol Nurs. 2004;24:202.

    PubMed  Google Scholar 

  58. Ripoll E, Mahowald D. Hatha yoga therapy management of urologic disorders. World J Urol. 2002;20:306.

    PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Boston Urogynecology Associates, Boston, MA, USA

    Leah Moynihan R.N.C., M.S.N.

  2. Mount Auburn Hospital, Harvard University School of Medicine, 725 Concord Ave, Cambridge, MA, 02138, USA

    Eman Elkadry M.D.

Authors
  1. Leah Moynihan R.N.C., M.S.N.
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Eman Elkadry M.D.
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Spaulding Rehabiliation Hospital, Nashua Street 125, Boston, 02114, Massachusetts, USA

    Allison Bailey

  2. , Departments of Anesthesia, Neurology, Cr, Beth Israel Deaconness Medical Center, H, One Brookline Place, Suite 105, Brookline, 02445-7294, USA

    Carolyn Bernstein

Rights and permissions

Reprints and permissions

Copyright information

© 2013 Springer Science+Business Media New York

About this chapter

Cite this chapter

Moynihan, L., Elkadry, E. (2013). Painful Bladder Syndrome/Interstitial Cystitis in Women. In: Bailey, A., Bernstein, C. (eds) Pain in Women. Springer, New York, NY. https://doi.org/10.1007/978-1-4419-7113-5_7

Download citation

  • DOI: https://doi.org/10.1007/978-1-4419-7113-5_7

  • Published:

  • Publisher Name: Springer, New York, NY

  • Print ISBN: 978-1-4419-7112-8

  • Online ISBN: 978-1-4419-7113-5

  • eBook Packages: MedicineMedicine (R0)

Publish with us

Policies and ethics

Search

Navigation