Sinusoidal Endothelial Cells

Part of the Molecular Pathology Library book series (MPLB, volume 5)


In all organs in the body, the vasculature is lined by simple, squamous epithelium, properly termed endothelium. However, the endothelia represent an extremely heterogeneous population of cells, and those of each organ, or more appropriately, each specific functional part of an organ, maintain characteristic features that enable the vasculature to perform particular roles at the blood–tissue interface [1, 2]. Regardless of the organ in question, the endothelia in normal tissues maintain a nonthrombogenically lined conduit through which a variety of blood cells and vehicle (plasma) assist in delivering oxygen, nutrients, and maintenance factors to, while removing debris, waste, and breakdown products from the underlying tissue. While the liver sinusoidal endothelium undeniably perform these duties, they possess additional phenotypes with a wide variety of unique capabilities essential to maintaining liver function.


Kupffer Cell Stellate Cell Vascular Endothelial Cell Growth Factor Nonparenchymal Cell Sinusoidal Obstruction Syndrome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.



The author acknowledges the amazing technical assistance of the entire staff of the Center for Biologic Imaging, at the University of Pittsburgh Medical School, but especially Mark Ross for his dedication to all aspects of liver processing and imaging. Supported by NIH grant R01 CA76541 to DBS.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Cell Biology and PhysiologyUniversity of PittsburghPittsburghUSA

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