Hepatocyte Growth, Proliferation and Experimental Carcinogenesis

  • Giovanna Maria Ledda-Columbano
  • Amedeo Columbano
Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 5)

Abstract

Adult liver is normally quiescent and has a very low level of hepatocyte cell division. However, most hepatocytes rapidly proliferate in response to a reduction in liver mass caused by physical, chemical, nutritional, vascular, or virus-induced liver injury. In spite of the several studies aimed to understand the molecular mechanisms responsible for hepatocyte proliferation, the exact mechanisms responsible for the exit from the quiescent state and the re-entry into the cell cycle remain unknown.

Keywords

Adenoma Adduct Glutamine Aflatoxin Hypothyroidism 

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Giovanna Maria Ledda-Columbano
  • Amedeo Columbano
    • 1
  1. 1.Department of Toxicology, School of MedicineUniversity of CagliariCagliariItaly

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