Biliary Atresia

Part of the Molecular Pathology Library book series (MPLB, volume 5)


Biliary atresia is a disease of mosts. It is the most common cause of neonatal cholestasis and the most frequent indication for liver transplant in the pediatric population worldwide, accounting for 40–50% of all liver transplants in children [1]. The health care costs associated with biliary atresia are significant, reaching $65 million/year in the USA alone [1]. Despite the obvious adverse impact to children’s health, advances in understanding of the etiology and pathogenesis of biliary atresia have not kept pace with the progress in other cholestatic disorders of childhood [2]. Biliary atresia has been the most challenging pediatric liver disease to understand and treat. The lack of progress reflects the multifactorial nature of the disease, which has challenged physicians since it was recognized early in the nineteenth century [3].


Bile Duct Biliary Atresia Extrahepatic Bile Duct Intrahepatic Cholestasis Porta Hepatis 



This work was supported by the NIH grants DK64008 and DK83781. Dr. Bezerra is the Cincinnati Principal Investigator of the NIDDK-funded Childhood Liver Disease Research and Education Network (NIH grant DK62497).


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Gastroenterology, Hepatology and NutritionCincinnati Children’s Hospital Medical CenterCincinnatiUSA

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