Viral Hepatitis A

Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 5)

Abstract

Hepatitis A is generally an acute, self-limiting infection of the liver caused by hepatitis A virus (HAV). Infection may be asymptomatic or result in acute hepatitis. Rarely, fulminant hepatitis may occur. Hepatitis A infections never cause chronic liver disease.

Keywords

Fatigue Europe Attenuation Steam Recombination 

References

  1. 1.
    Zuckerman AJ. The history of viral hepatitis from antiquity to the present. In: Deinhardt F, Deinhardt J, editors. Viral hepatitis: laboratory and clinical science. New York: Marcel Dekker; 1983. p. 3–32.Google Scholar
  2. 2.
    McDonald S. Acute yellow atrophy of the liver. Edinb Med J. 1907;1:83.Google Scholar
  3. 3.
    MacCallum FO. Early studies on viral hepatitis. Br Med Bull. 1972;28:105–8.PubMedGoogle Scholar
  4. 4.
    Havens WPJ, Ward R, Drill VA, et al. Experimental production of hepatitis by feeding icterogenic materials. Proc Soc Exp Biol Med. 1944;57:206–8.Google Scholar
  5. 5.
    Gellis SS, Stokes Jr J, Brother GM, et al. The use of immune globulin (gamma globulin) in infectious (epidemic) hepatitis in the Mediterranian theatre of operations. JAMA. 1945;128:1062.Google Scholar
  6. 6.
    Feinstone SM, Kapikian AZ, Purcell RH. Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness. Science. 1973;182:1026–8.PubMedGoogle Scholar
  7. 7.
    Andre FE, D’Hondt E, Delem A, et al. Clinical assessment of the safety and efficacy of an inactivated hepatitis A vaccine: rationale and summary of findings. Vaccine. 1992;10 Suppl 1:S160–8.PubMedGoogle Scholar
  8. 8.
    Pringle CR. Virus taxonomy–San Diego 1998. Arch Virol. 1998;143:1449–59.PubMedGoogle Scholar
  9. 9.
    Coulepis AG, Locarnini SA, Westaway EG, et al. Biophysical and biochemical characterization of hepatitis V virus. Intervirology. 1982;18:107–27.PubMedGoogle Scholar
  10. 10.
    Nissen E, Konig P, Feinstone SM, et al. Inactivation of hepatitis A and other enteroviruses during heat treatment (pasteurization). Biologicals. 1996;24:339–41.PubMedGoogle Scholar
  11. 11.
    Peterson DA, Hurley TR, Hoff JC, et al. Effect of chlorine treatment on infectivity of hepatitis A virus. Appl Environ Microbiol. 1983;45:223–7.PubMedGoogle Scholar
  12. 12.
    Grove SF, Lee A, Lewis T, Stewart CM, Chen H, Hoover DG. Inactivation of foodborne viruses of significance by high pressure and other processes. J Food Prot. 2006;69:957–68.PubMedGoogle Scholar
  13. 13.
    Shimasaki N, Kiyohara T, Totsuka A, Nojima K, Okada Y, Yamaguchi K, et al. Inactivation of hepatitis A virus by heat and high hydrostatic pressure: variation among laboratory strains. Vox Sang. 2009;96(1):14–9.PubMedGoogle Scholar
  14. 14.
    Martin A, Lemon SM. Hepatitis A virus: from discovery to vaccines. Hepatology. 2006;43(2 Suppl 1):S164–72.PubMedGoogle Scholar
  15. 15.
    Cohen JI, Rosenblum B, Ticehurst JR, et al. Complete nucleotide sequence of an attenuated hepatitis A virus: Comparison with wild-type virus. Proc Natl Acad Sci U S A. 1987;84:2497–501.PubMedGoogle Scholar
  16. 16.
    Ruckert RR, Wimmer E. Systematic nomenclature of picornavirus proteins. J Virol. 1984;50:957–9.Google Scholar
  17. 17.
    Tratschin JD, Siegl G, Frosner GG, et al. Characterization and classification of virus particles associated with hepatitis A. III. Structural proteins. J Virol. 1981;38:151–6.PubMedGoogle Scholar
  18. 18.
    Gosert R, Egger D, Bienz K. A cytopathic and a cell culture adapted hepatitis A virus strain differ in cell killing but not in intracellular membrane rearrangements. Virology. 2000;266:157–69.PubMedGoogle Scholar
  19. 19.
    Cohen L, Benichou D, Martin A. Analysis of deletion mutants indicates that the 2A polypeptide of hepatitis A virus participates in virion morphogenesis. J Virol. 2002;76:7495–505.PubMedGoogle Scholar
  20. 20.
    Probst C, Jecht M, Gauss-Muller V. Intrinsic signals for the assembly of hepatitis A virus particles: role of structural proteins VP4 and 2A. J Biol Chem. 1999;274:4527–31.PubMedGoogle Scholar
  21. 21.
    Provost PJ, Hilleman MR. Propagation of human hepatitis A virus in cell culture in vitro. Proc Soc Exp Biol Med. 1979;160:213–21.PubMedGoogle Scholar
  22. 22.
    Cromeans T, Fields HA, Sobsey MD. Replication kinetics and cytopathic effect of hepatitis A virus. J Gen Virol. 1989;70:2051–62.PubMedGoogle Scholar
  23. 23.
    Bishop NE, Anderson DA. Uncoating kinetics of hepatitis A virus virions and provirions. J Virol. 2000;74:3423–6.PubMedGoogle Scholar
  24. 24.
    de Chastonay J, Siegl G. Replicative events in hepatitis A virus-infected MRC-5 cells. Virology. 1987;157:268–75.PubMedGoogle Scholar
  25. 25.
    Yi M, Lemon SM. Replication of subgenomic hepatitis A virus RNAs expressing firefly luciferase is enhanced by mutations associated with adaptation of virus to growth in cultured cells. J Virol. 2002;76:1171–80.PubMedGoogle Scholar
  26. 26.
    Brack K, Frings W, Dotzauer A, Vallbracht A. A cytopathogenic, apoptosis- inducing variant of hepatitis A virus. J Virol. 1998;72:3370–6.PubMedGoogle Scholar
  27. 27.
    Cromeans T, Sobsey MD, Fields HA. Development of a plaque assay for a cytopathic, rapidly replicating isolate of hepatitis A virus. J Med Virol. 1987;22:45–56.PubMedGoogle Scholar
  28. 28.
    Brack K, Berk I, Magulski T, Lederer J, Dotzauer A, Vallbracht A. Hepatitis A virus inhibits cellular antiviral defense mechanisms induced by double-stranded RNA. J Virol. 2002;76:11920–30.PubMedGoogle Scholar
  29. 29.
    Blank CA, Anderson DA, Beard M, Lemon SM. Infection of polarized cultures of human intestinal epithelial cells with hepatitis A virus: vectorial release of progeny virions through apical cellular membranes. J Virol. 2000;74:6476–84.PubMedGoogle Scholar
  30. 30.
    Karayiannis P, Jowett T, Enticott M, et al. Hepatitis A virus replication in tamarins and host immune response in relation to pathogenesis of liver cell damage. J Med Virol. 1986;18:261–76.PubMedGoogle Scholar
  31. 31.
    Feigelstock D, Thompson P, Mattoo P, et al. The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor. J Virol. 1998;72:6621–8.PubMedGoogle Scholar
  32. 32.
    Silberstein E, Xing L, van de Beek W, Lu J, Cheng H, Kaplan GG. Alteration of hepatitis A virus (HAV) particles by a soluble form of HAV cellular receptor 1 containing the immunoglobin- and mucin-like regions. J Virol. 2003;77:8765–74.PubMedGoogle Scholar
  33. 33.
    Tami C, Silberstein E, Manangeeswaran M, Freeman GJ, Umetsu SE, DeKruyff RH, et al. Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions. J Virol. 2007;81(7):3437–46.PubMedGoogle Scholar
  34. 34.
    Rico-Hesse R, Pallansch MA, Nottay BK, Kew OM. Geographic distribution of wild poliovirus type 1 genotypes. Virology. 1987;160:311–22.PubMedGoogle Scholar
  35. 35.
    Robertson BH, Jansen RW, Khanna B, Totsuka A, Nainan OV, Siegl G, et al. Genetic relatedness of hepatitisAvirus strains recovered from different geographical regions. J Gen Virol. 1992;73:1365–77.PubMedGoogle Scholar
  36. 36.
    Costa-Mattioli M, Cristina J, Romero H, Perez-Bercoff R, Casane D, Colina R, et al. Molecular evolution of hepatitis A virus: a new classification based on the complete VP1 protein. J Virol. 2002;76:9515–25.Google Scholar
  37. 37.
    Costa-Mattioli M, Ferre V, Casane D, Perez-Bercoff R, Coste-Burel M, Imbert-Marcille BM, et al. Evidence of recombination in natural populations of hepatitis A virus. Virology. 2003;311:51–9.PubMedGoogle Scholar
  38. 38.
    Lu L, Ching KZ, Salete de Paula V, Nakano T, Siegl G, Weitz M, et al. Characterization of the complete genomic sequence of genotype II hepatitis A virus (CF53/Berne isolate). J Gen Virol. 2004;85:2943–52.PubMedGoogle Scholar
  39. 39.
    Cristina J, Costa-Mattioli M. Genetic variability and molecular evolution of hepatitis A virus. Virus Res. 2007;127(2):151–7.PubMedGoogle Scholar
  40. 40.
    Perevoscikovs J, Lucenko I, Magone S, Brila A, Curikova J, Vennema H. Community-wide outbreak of hepatitis A in Latvia in 2008—an update. Euro Surveill. 2009;14(3):pii: 19092.Google Scholar
  41. 41.
    Chitambar S, Joshi M, Lole K, Walimbe A, Vaidya S. Cocirculation of and coinfections with hepatitis A virus subgenotypes IIIA and IB in patients from Pune, western India. Hepatol Res. 2007;37(2):85–93.PubMedGoogle Scholar
  42. 42.
    Gauss-Muller V, Kusov YY. Replication of a hepatitis A virus replicon detected by genetic recombination in vivo. J Gen Virol. 2002;83:2183–92.PubMedGoogle Scholar
  43. 43.
    de Paula VS, Saback FL, Gaspar AM, Niel C. Mixed infection of a child care provider with hepatitis A virus isolates from subgenotypes IA and IB revealed by heteroduplex mobility assay. J Virol Methods. 2003;107:223–8.PubMedGoogle Scholar
  44. 44.
    Costa-Mattioli M, Domingo E, Cristina J. Analysis of sequential hepatitis A virus strains reveals coexistence of distinct viral subpopulations. J Gen Virol. 2006;87:115–8.PubMedGoogle Scholar
  45. 45.
    Sanchez G, Bosch A, Gomez-Mariano G, Domingo E, Pinto RM. Evidence for quasispecies distributions in the human hepatitis A virus genome. Virology. 2003;315:34–42.PubMedGoogle Scholar
  46. 46.
    Xia G, Yi Y, Guo K, Tian H. Comparison of the Chinese LJ strain structural gene with HM175, MBB, LA strains and the expression of hepatitis A virus antigen by LJ/HM175 recombinant vaccinia virus. Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi. 1997;11:208–11.PubMedGoogle Scholar
  47. 47.
    Hillis WD. Viral hepatitis: a vulnerable foe. Mil Med. 1978;143:86–93.PubMedGoogle Scholar
  48. 48.
    Deinhardt F. Hepatitis in primates. Adv Virus Res. 1976;20:113–57.PubMedGoogle Scholar
  49. 49.
    Deinhardt F, Holmes AW, Capps RB, et al. Studies on the transmission of human viral hepatitis to marmoset monkeys. J Exp Med. 1967;125:673–89.PubMedGoogle Scholar
  50. 50.
    Maynard JE, Lorenz D, Bradley DW, et al. Review of infectivity studies in nonhuman primates with virus-like particles associated with MS-1 hepatitis. Am J Med Sci. 1975;270:81–5.PubMedGoogle Scholar
  51. 51.
    Arankalle VA, Ramakrishnan J. Simian hepatitis A virus derived from a captive rhesus monkey in India is similar to the strain isolated from wild African green monkeys in Kenya. J Viral Hepat. 2009;16(3):214–8.PubMedGoogle Scholar
  52. 52.
    LeDuc JW, Escajadillo A, Lemon SM. Hepatitis A virus among captive Panamanian owl monkeys (Letter). Lancet. 1981;2:1427–8.PubMedGoogle Scholar
  53. 53.
    Hilleman MR, Provost PJ, Villarejos VM, et al. Infectious hepatitis (hepatitis A) research in nonhuman primates. Bull Pan Am Health Organ. 1977;11:140–52.PubMedGoogle Scholar
  54. 54.
    Skinhoj P, Mathiesen LR, Kryger P. Faecal excretion of hepatitis A virus in patients with symptomatic hepatitis A infection. Ann Intern Med. 1987;106:221–6.Google Scholar
  55. 55.
    Rosenblum LS, Villarino ME, Nainan OV, et al. Hepatitis A outbreak in a neonatal intensive care unit: risk factors for transmission and evidence of prolonged viral excretion among preterm infants. J Infect Dis. 1991;164:476–82.PubMedGoogle Scholar
  56. 56.
    Sjogren MH, Tanno H, Fay O, et al. Hepatitis A virus in stool during clinical relapse. Ann Intern Med. 1987;106:221–6.PubMedGoogle Scholar
  57. 57.
    Purcell RH, Wong DC, Shapiro M. Relative infectivity of hepatitis A virus by the oral and intravenous routes in 2 species of nonhuman primates. J Infect Dis. 2002;185:1668–771.PubMedGoogle Scholar
  58. 58.
    Cohen JI, Feinstone S, Purcell RH. Hepatitis A virus infection in a chimpanzee: duration of viremia and detection of virus in saliva and throat swabs. J Infect Dis. 1989;160:887–90.PubMedGoogle Scholar
  59. 59.
    Chadha MS, Lole KS, Bora MH, Arankalle VA. Outbreaks of hepatitis A among children in western India. Trans R Soc Trop Med Hyg. 2009;103:911–6.PubMedGoogle Scholar
  60. 60.
    Fiore A. Foodborne hepatitis A. Clin Infect Dis. 2004;38:705–15.PubMedGoogle Scholar
  61. 61.
    Venczel LV, Desai MM, Vertz PD, et al. The role of child care in a community-wide outbreak of hepatitis A. Pediatrics. 2001;108:E78.PubMedGoogle Scholar
  62. 62.
    Jackson LA, Stewart LK, Solomon SL, et al. Risk of infection with hepatitis A, B or C, cytomegalovirus, varicella or measles among child care providers. Pediatr Infect Dis J. 1996;15:584–9.PubMedGoogle Scholar
  63. 63.
    Sayers G, Dooley S, Staines A, Lane J, Thornton L, Staines M, Brennan S, Kelly P, Finlay F. Hepatitis A antibody prevalence among people with an intellectual disability in Ireland. Euro Surveill. 2007;12(1).Google Scholar
  64. 64.
    Latimer WW, Moleko AG, Melnikov A, Mitchell M, Severtson SG, von Thomsen S, et al. Prevalence and correlates of hepatitis A among adult drug users: the significance of incarceration and race/ethnicity. Vaccine. 2007;25(41):7125–31.PubMedGoogle Scholar
  65. 65.
    Hutin YJ, Sabin KM, Hutwanger LC, et al. Multiple modes of hepatitis A virus transmission among methamphetamine users. Am J Epidemiol. 2000;152:186–92.PubMedGoogle Scholar
  66. 66.
    Stene-Johansen K, Tjon G, Schreier E, Bremer V, Bruisten S, Ngui SL, et al. Molecular epidemiological studies show that hepatitis A virus is endemic among active homosexual men in Europe. J Med Virol. 2007;79(4):356–65.PubMedGoogle Scholar
  67. 67.
    Katz MH, Hsu L, Wong E, et al. Seroprevalence of and risk factors for hepatitis A infection among young homosexual and bisexual men. J Infect Dis. 1997;175:1225–9.PubMedGoogle Scholar
  68. 68.
    Villano SA, Nelson KE, Vlahov D, et al. Hepatitis A among homosexual men and injection drug users: more evidence for vaccination. Clin Infect Dis. 1997;25:726–8.PubMedGoogle Scholar
  69. 69.
    Henning KJ, Bell E, Braun J, et al. A community-wide outbreak of hepatitis A risk factors for infection among homosexual and bisexual men. Am J Med. 1995;99:132–6.PubMedGoogle Scholar
  70. 70.
    Cotter SM, Sansom S, Long T, et al. Outbreak of hepatitis A among men who have sex with men: implications for hepatitis A vaccination strategies. J Infect Dis. 2003;187:1235–40.PubMedGoogle Scholar
  71. 71.
    Gowland P, Fontana S, Niederhauser C, Taleghani BM. Molecular and serologic tracing of a transfusion-transmitted hepatitis A virus. Transfusion. 2004;44:1555–61.PubMedGoogle Scholar
  72. 72.
    Siagris D, Kouraklis-Symeonidis A, Konstantinidou I, Christofidou M, Starakis I, Lekkou A, et al. Prevalence of anti-HAV antibodies in multitransfused patients with beta-thalassemia. World J Gastroenterol. 2008;14(10):1559–63.PubMedGoogle Scholar
  73. 73.
    Mannucci PM, Santagostino E, Di Bona E, et al. The outbreak of hepatitis A in Italian patients with hemophilia: facts and fancies. Vox Sang. 1994;67 Suppl 1:31–5.PubMedGoogle Scholar
  74. 74.
    Klein BS, Michaels JA, Rytel MW, et al. Nosocomial hepatitis A. A multinursery outbreak in Wisconsin. JAMA. 1984;252:2716–21.PubMedGoogle Scholar
  75. 75.
    Noble RC, Kane MA, Reeves SA, et al. Posttransfusion hepatitis A in a neonatal intensive care unit. JAMA. 1984;252:2711–5.PubMedGoogle Scholar
  76. 76.
    Weisfuse IB, Graham DJ, Will M, et al. An outbreak of hepatitis A among cancer patients treated with interleukin-2 and lymphokine-activated killer cells. J Infect Dis. 1990;161:647–52.PubMedGoogle Scholar
  77. 77.
    Goodman RA. Nosocomial hepatitis A. Ann Intern Med. 1985;103:452–4.PubMedGoogle Scholar
  78. 78.
    Frank C, Walter J, Muehlen M, Jansen A, van Treeck U, Hauri AM, et al. Major outbreak of hepatitis A associated with orange juice among tourists, Egypt, 2004. Emerg Infect Dis. 2007;13(1):156–8.PubMedGoogle Scholar
  79. 79.
    Nielsen US, Larsen CS, Howitz M, Petersen E. Hepatitis A among Danish travellers 1980–2007. J Infect. 2009;58(1):47–52.PubMedGoogle Scholar
  80. 80.
    Steffen R, Kane MA, Shapiro CN, et al. Epidemiology and prevention of hepatitis A in travelers. JAMA. 1994;272:885–9.PubMedGoogle Scholar
  81. 81.
    Christenson B. Epidemiological aspects of acute viral hepatitis A in Swedish travellers to endemic areas. Scand J Infect Dis. 1985;17:5–10.PubMedGoogle Scholar
  82. 82.
    Schmid D, Fretz R, Buchner G, König C, Perner H, Sollak R, et al. Foodborne outbreak of hepatitis A, November 2007-January 2008, Austria. Eur J Clin Microbiol Infect Dis. 2009;28(4):385–91.PubMedGoogle Scholar
  83. 83.
    Dentinger CM, Bower WA, Nainan OV, et al. An outbreak of hepatitis A associated with green onions. J Infect Dis. 2001;183:1273–6.PubMedGoogle Scholar
  84. 84.
    Shieh YC, Khudyakov YE, Xia G, Ganova-Raeva LM, Khambaty FM, Woods JW, et al. Molecular confirmation of oysters as the vector for hepatitis A in a 2005 multistate outbreak. J Food Prot. 2007;70(1):145–50.PubMedGoogle Scholar
  85. 85.
    Pontrelli G, Boccia D, DI Renzi M, Massari M, Giugliano F, Celentano LP, et al. Epidemiological and virological characterization of a large community-wide outbreak of hepatitis A in southern Italy. Epidemiol Infect. 2008;136(8):1027–34.PubMedGoogle Scholar
  86. 86.
    Montuori P, Negrone M, Cacace G, Triassi M. Wastewater workers and hepatitis A virus infection. Occup Med (Lond). 2009;59:506–8.Google Scholar
  87. 87.
    Hadler SC. Global impact of hepatitis A virus infection: changing patterns. In: Hollinger FB, Lemon SM, Margolis HS, editors. Viral hepatitis and liver disease. Baltimore: Williams & Wilkins; 1991. p. 14–20.Google Scholar
  88. 88.
    Kaya AD, Ozturk CE, Yavuz T, Ozaydin C, Bahcebasi T. Changing patterns of hepatitis A and E sero-prevalences in children after the 1999 earthquakes in Duzce, Turkey. J Paediatr Child Health. 2008;44(4):205–7.PubMedGoogle Scholar
  89. 89.
    Matos MA, Reis NR, Kozlowski AG, Teles SA, Motta-Castro AR, Mello FC, et al. Epidemiological study of hepatitis A, B and C in the largest Afro-Brazilian isolated community. Trans R Soc Trop Med Hyg. 2009;103:899–905.PubMedGoogle Scholar
  90. 90.
    Fischer GE, Thompson N, Chaves SS, Bower W, Goldstein S, Armstrong G, et al. The epidemiology of hepatitis A virus infections in four Pacific Island nations, 1995–2008. Trans R Soc Trop Med Hyg. 2009;103:906–10.PubMedGoogle Scholar
  91. 91.
    MacIntyre CR, Burgess M, Isaacs D, McIntyre PB, Menzies R, Hull B. Epidemiology of severe hepatitis A in Indigenous Australian children. J Paediatr Child Health. 2007;43(5):383–7.PubMedGoogle Scholar
  92. 92.
    Bowden FJ, Currie BJ, Miller NC, et al. Should aboriginals in the “top end” of the Northern Territory be vaccinated against hepatitis A? Med J Aust. 1994;161:372–3.PubMedGoogle Scholar
  93. 93.
    Payne L, Coulombier D. Hepatitis A in the European Union: responding to challenges related to new epidemiological patterns. Euro Surveill. 2009;14(3):pii: 19101.Google Scholar
  94. 94.
    Cianciara J. Hepatitis A shifting epidemiology in Poland and Eastern Europe. Vaccine. 2000;18 Suppl 1:S68–70.PubMedGoogle Scholar
  95. 95.
    Green MS, Block C, Slater PE. Rise in the incidence of viral hepatitis in Israel despite improved socioeconomic conditions. Rev Infect Dis. 1989;11:464–9.PubMedGoogle Scholar
  96. 96.
    Halliday ML, Kang LY, Zhou TK, et al. An epidemic of hepatitis A attributable to the ingestion of raw clams in Shanghai, China. J Infect Dis. 1991;164:852–9.PubMedGoogle Scholar
  97. 97.
    Kiyohara T, Sato T, Totsuka A, Miyamura T, Ito T, Yoneyama T. Shifting seroepidemiology of hepatitis A in Japan, 1973–2003. Microbiol Immunol. 2007;51(2):185–91.PubMedGoogle Scholar
  98. 98.
    Chatproedprai S, Chongsrisawat V, Chatchatee P, Theamboonlers A, Yoocharoen P, Warinsathien P, et al. Declining trend in the seroprevalence of infection with hepatitis A virus in Thailand. Ann Trop Med Parasitol. 2007;101(1):61–8.PubMedGoogle Scholar
  99. 99.
    Al Faleh F, Al Shehri S, Al Ansari S, Al Jeffri M, Al Mazrou Y, Shaffi A, et al. Changing patterns of hepatitis A prevalence within the Saudi population over the last 18 years. World J Gastroenterol. 2008;14(48):7371–5.PubMedGoogle Scholar
  100. 100.
    Cui F, Hadler SC, Zheng H, Wang F, Zhenhua W, Yuansheng H, et al. Hepatitis A surveillance and vaccine use in China from 1990 through 2007. J Epidemiol. 2009;19(4):189–95.PubMedGoogle Scholar
  101. 101.
    Mathur P, Arora NK. Epidemiological transition of hepatitis A in India: issues for vaccination in developing countries. Indian J Med Res. 2008;128:699–704.PubMedGoogle Scholar
  102. 102.
    Tufenkeji H. Hepatitis A shifting epidemiology in the Middle East and Africa. Vaccine. 2000;18 Suppl 1:S65–7.PubMedGoogle Scholar
  103. 103.
    Ciocca M, Moreira-Silva SF, Alegría S, Galoppo MC, Ruttiman R, Porta G, et al. Hepatitis A as an etiologic agent of acute liver failure in Latin America. Pediatr Infect Dis J. 2007;26(8):711–5.PubMedGoogle Scholar
  104. 104.
    Ciocca M. Clinical course and consequences of hepatitis A infection. Vaccine. 2000;18 Suppl 1:S71–4.PubMedGoogle Scholar
  105. 105.
    Craig AS, Watson B, Zink TK, Davis JP, Yu C, Schaffner W. Hepatitis A outbreak activity in the United States: responding to a vaccine-preventable disease. Am J Med Sci. 2007;334(3):180–3.PubMedGoogle Scholar
  106. 106.
    Daniels D, Grytdal S, Wasley A. Centers for Disease Control and Prevention (CDC). Surveillance for acute viral hepatitis – United States, 2007. MMWR Surveill Summ. 2009;58(3):1–27.PubMedGoogle Scholar
  107. 107.
    Berlioz-Arthaud A, Barny S, Yvon JF, Roque-Afonso AM, Dussaix E. Laboratory based hepatitis A surveillance in New Caledonia: from an endemic to an epidemic pattern (1986–2007). Bull Soc Pathol Exot. 2008;101(4):336–42 [Article in French].PubMedGoogle Scholar
  108. 108.
    O’Donovan D, Cooke RP, Joce R, et al. An outbreak of hepatitis A amongst injecting drug users. Epidemiol Infect. 2001;127:469–73.PubMedGoogle Scholar
  109. 109.
    Emerson SU, Huang YK, Purcell RH. 2B and 2C mutations are essential but mutations throughout the genome of HAV contribute to adaptation to cell culture. Virology. 1993;194:475–80.PubMedGoogle Scholar
  110. 110.
    Asher LVS, Binn LN, Mensing TL, Marchwicki RH, Vassell RA, Young GD. Pathogenesis of hepatitis A in orally inoculated owl monkeys (Aotus trivergatus). J Med Virol. 1995;47:260–8.PubMedGoogle Scholar
  111. 111.
    Lemon SM. The natural history of hepatitis A: the potential for transmission by transfusion of blood or blood products. Vox Sang. 1994;67 Suppl 4:19–23.PubMedGoogle Scholar
  112. 112.
    Bower WA, Nainan OV, Han X, Margolis HS. Duration of viremia in hepatitis A virus infection. J Infect Dis. 2000;182:12–7.PubMedGoogle Scholar
  113. 113.
    Mackiewicz V, Dussaix E, Le Petitcorps MF, Roque-Afonso AM. Detection of hepatitis A virus RNA in saliva. J Clin Microbiol. 2004;42:4329–31.PubMedGoogle Scholar
  114. 114.
    Mathiesen LR, Drucker J, Lorenz D, Wagner J, Gerety RJ, Purcell RH. Localization of hepatitis A antigen in marmoset organs during acute infection with hepatitis A virus. J Infect Dis. 1978;138:369–77.PubMedGoogle Scholar
  115. 115.
    Muraoka H. Clinical and epidemiological study on factors of serious development of viral hepatitis type A. Nippon Shokakibyo Gakkai Zasshi. 1990;87:1383–9121.PubMedGoogle Scholar
  116. 116.
    Fujiwara K, Yokosuka O, Ehata T, Imazeki F, Saisho H. PCR-SSCP analysis of 50 nontranslated region of hepatitis A viral RNA: comparison with clinicopathological features of hepatitis A. Dig Dis Sci. 2000;45:2422–7.PubMedGoogle Scholar
  117. 117.
    Zhang H, Chao S-F, Ping LH, et al. An infectious cDNA clone of a cytopathic hepatitis A virus: genomic regions associated with rapid replication and cytopathic effect. Virology. 1995;212:686–97.PubMedGoogle Scholar
  118. 118.
    Raychaudhuri G, Govindarajan S, Shapiro M, Purcell RH, Emerson SU. Utilization of chimeras between human (HM-175) and simian (AGM-27) strains of hepatitis A virus to study the molecular basis of virulence. J Virol. 1998;72:7467–75.PubMedGoogle Scholar
  119. 119.
    Fujiwara K, Kojima H, Yonemitsu Y, Yasui S, Imazeki F, Miki M, et al. Phylogenetic analysis of hepatitis A virus in sera from patients with hepatitis A of various severities. Liver Int. 2009;29(6):838–45.PubMedGoogle Scholar
  120. 120.
    Li K, Chen Z, Kato N, Gale Jr M, Lemon SM. Distinct poly-I:C and virus-activated interferon signaling pathways in hepatocytes. J Biol Chem. 2005;280:16739–47.PubMedGoogle Scholar
  121. 121.
    Fensterl V, Grotheer D, Berk I, Schlemminger S, Vallbracht A, Dotzauer A. Hepatitis A virus suppresses RIG-I-mediated IRF-3 activation to block induction of beta interferon. J Virol. 2005;79:10968–77.PubMedGoogle Scholar
  122. 122.
    Vallbracht A, Gabriel P, Maier K, Hartmann F, Steinhardt HJ, Muller C, et al. Cell-mediated cytotoxicity in hepatitis A virus infection. Hepatology. 1986;6:1308–14.PubMedGoogle Scholar
  123. 123.
    Pinto MA, Marchevsky RS, Pelajo-Machado M, et al. Inducible nitric oxide synthase (iNOS) expression in liver and splenic T lymphocyte rise are associated with liver histological damage during experimental hepatitis A virus (HAV) infection in Callithrix jacchus. Exp Toxicol Pathol. 2000;52:3–10.PubMedGoogle Scholar
  124. 124.
    Perrella A, Vitiello L, Atripaldi L, Sbreglia C, Grattacaso S, Bellopede P, et al. Impaired function of CD4+/CD25+ T regulatory lymphocytes characterizes the self-limited hepatitis A virus infection. J Gastroenterol Hepatol. 2008;23(7 Pt 2):e105–10.PubMedGoogle Scholar
  125. 125.
    Gibas A, Blewett DR, Schoenfeld DA, et al. Prevalence and incidence of viral hepatitis in health workers in the prehepatitis B vaccination era. Am J Epidemiol. 1992;136:603–10.PubMedGoogle Scholar
  126. 126.
    Skinhoj P, Mikkelsen F, Hollinger FB. Hepatitis A in Greenland: importance of specific antibody testing in epidemiologic surveillance. Am J Epidemiol. 1977;105:140–7.PubMedGoogle Scholar
  127. 127.
    Stapleton JT, Lange DK, LeDuc JW, Binn LN, Jansen RW, Lemon SM. The role of secretory immunity in hepatitis A virus infection. J Infect Dis. 1991;163:7–11.PubMedGoogle Scholar
  128. 128.
    Oba IT, Spina AM, Saraceni CP, Lemos MF, Senhoras R, Moreira RC, et al. Detection of hepatitis A antibodies by ELISA using saliva as clinical samples. Rev Inst Med Trop Sao Paulo. 2000;42:197–200.PubMedGoogle Scholar
  129. 129.
    Jacobson SK, Buttery R, Parry JV, Perry KR, Wreghitt TG. Investigation of a hepatitis A outbreak in a primary school by sequential saliva sampling. Clin Diagn Virol. 1995;3:173–80.PubMedGoogle Scholar
  130. 130.
    Robertson BH, Jia XY, Tian H, Margolis HS, Summers DF, Ehrenfeld E. Antibody response to nonstructural proteins of hepatitis A virus following infection. J Med Virol. 1993;40:76–82.PubMedGoogle Scholar
  131. 131.
    Stewart DR, Morris TS, Purcell RH, Emerson SU. Detection of antibodies to the nonstructural 3C proteinase of hepatitis A virus. J Infect Dis. 1997;176:593–601.PubMedGoogle Scholar
  132. 132.
    Matricardi PM, Rosmini F, Panetta V, et al. Hay fever and asthma in relation to markers of infection in the United States. J Allergy Clin Immunol. 2002;110:381–7.PubMedGoogle Scholar
  133. 133.
    McIntire JJ, Umetsu SE, Akbari O, et al. Identification of Tapr (an airway hyperreactivity regulatory locus) and the linked Tim gene family. Nat Immunol. 2001;2:1109–16.PubMedGoogle Scholar
  134. 134.
    Abe H, Beninger PR, Ikejiri N, et al. Light microscopic findings of liver biopsy specimens from patients with hepatitis type A and comparison with type B. Gastroenterology. 1982;82:938–47.PubMedGoogle Scholar
  135. 135.
    Mathiesen LR. The hepatitis A virus infection. Liver. 1981;1:81–109.PubMedGoogle Scholar
  136. 136.
    Motte A, Blanc J, Minodier P, Colson P. Acute hepatitis A in a pregnant woman at delivery. Int J Infect Dis. 2009;13(2):e49–51.PubMedGoogle Scholar
  137. 137.
    Elinav E, Ben-Dov IZ, Shapira Y, Daudi N, Adler R, Shouval D, et al. Acute hepatitis A infection in pregnancy is associated with high rates of gestational complications and preterm labor. Gastroenterology. 2006;130:1129–34.PubMedGoogle Scholar
  138. 138.
    Anon. Prevention of hepatitis A through active or passive immunization. Recommendations of the advisory committee on immunization practices (ACIP). Morb Mortal Wkly Rep 2006;55(RR07):1–23.Google Scholar
  139. 139.
    Leikin E, Lysikiewicz A, Garry D, Tejani N. Intrauterine transmission of hepatitis A virus. Obstet Gynecol. 1996;88:690–1.PubMedGoogle Scholar
  140. 140.
    McDuffie Jr RS, Bader T. Fetal meconium peritonitis after maternal hepatitis A. Am J Obstet Gynecol. 1999;180:1031–2.PubMedGoogle Scholar
  141. 141.
    Renge RL, Dani VS, Chitambar SD, Arankalle VA. Vertical transmission of hepatitis A. Indian J Pediatr. 2002;69:535–6.PubMedGoogle Scholar
  142. 142.
    Watson JC, Fleming DW, Borella AJ, Olcott ES, Conrad RA, Baron RC. Vertical transmission of hepatitis A resulting in an outbreak in a neonatal intensive care unit. J Infect Dis. 1993;167:567–71.PubMedGoogle Scholar
  143. 143.
    Tanaka I, Shima M, Kubota Y, Takahashi Y, Kawamata O, Yoshioka A. Vertical transmission of hepatitis A virus. Lancet. 1995;345:397.PubMedGoogle Scholar
  144. 144.
    Erkan T, Kutlu T, Cullu F, Tumay GT. A case of vertical transmission of hepatitis A virus infection. Acta Paediatr. 1998;87:1008–9.PubMedGoogle Scholar
  145. 145.
    Urganci N, Arapoglu M, Akyildiz B, Nuhoglu A. Neonatal cholestasis resulting from vertical transmission of hepatitis A infection. Pediatr Infect Dis J. 2003;22:381–2.PubMedGoogle Scholar
  146. 146.
    Coppola N, Genovese D, Pisaturo M, Taffon S, Argentini C, Pasquale G, et al. Acute hepatitis with severe cholestasis and prolonged clinical course due to hepatitis A virus Ia and Ib coinfection. Clin Infect Dis. 2007;44(9):e73–7.PubMedGoogle Scholar
  147. 147.
    Tong MJ. el-Farra NS, Grew MI: Clinical manifestations of hepatitis A: recent experience in a community teaching hospital. J Infect Dis. 1995;171 Suppl 1:S15–8.PubMedGoogle Scholar
  148. 148.
    Gordon SC, Reddy KR, Schiff L, et al. Prolonged intrahepatic cholestasis secondary to acute hepatitis A. Ann Intern Med. 1984;101:635–7.PubMedGoogle Scholar
  149. 149.
    Tong MJ, el-Farra NS, Grew MI. Clinical manifestations of hepatitis A: recent experience in a community teaching hospital. J Infect Dis. 1995;171 Suppl 1:S15–8.PubMedGoogle Scholar
  150. 150.
    Poddar U, Thapa BR, Prasad A, Singh K. Changing spectrum of sporadic acute viral hepatitis in Indian children. J Trop Pediatr. 2002;48:210–3.PubMedGoogle Scholar
  151. 151.
    Kumar A, Yachha SK, Poddar U, Singh U, Aggarwal R. Does co-infection with multiple viruses adversely influence the course and outcome of sporadic acute viral hepatitis in children? J Gastroenterol Hepatol. 2006;21(10):1533–7.PubMedGoogle Scholar
  152. 152.
    Zaki Mel S, Salama OS, Mansour FA, Hossein S. Hepatitis E virus coinfection with hepatotropic viruses in Egyptian children. J Microbiol Immunol Infect. 2008;41(3):254–8.PubMedGoogle Scholar
  153. 153.
    Keeffe EB. Is hepatitis A more severe in patients with chronic hepatitis B and other chronic liver diseases? Am J Gastroenterol. 1995;90:201–5.PubMedGoogle Scholar
  154. 154.
    Yao G. Clinical spectrum and natural history of viral hepatitis in a 1988 Shanghai epidemic. In: Hollinger FB, Lemon SM, Margolis H, editors. Viral hepatitis and liver disease. Baltimore: Lippincot Williams & Wilkins; 1991. p. 76–8.Google Scholar
  155. 155.
    Hadler SC. Global impact of hepatitis A virus infection changing patterns. In: Hollinger FB, Lemon SM, Margolis H, editors. Viral hepatitis and liver disease. Baltimore: Williams & Wilkins; 1990. p. 14–20.Google Scholar
  156. 156.
    Datta D, Williams I, Culver D, Bloom SC, Bell BP. Association between deaths due to hepatitis A and chronic liver disease, United States, 1981–1997 (Abstract). Antiviral Ther. 2000;5 Suppl 1:79–80.Google Scholar
  157. 157.
    Vento S, Garofano T, Renzini C, Cainelli F, Casali F, Ghironzi G, et al. Fulminant hepatitis associated with hepatitis A superinfection in patients with chronic hepatitis C. N Engl J Med. 1998;338:286–90.PubMedGoogle Scholar
  158. 158.
    Almasio PL, Amoroso P. HAV infection in chronic liver disease: a rationale for vaccination. Vaccine. 2003;21:2238–41.PubMedGoogle Scholar
  159. 159.
    Ferreira CT, Vieira SM, Kieling CO, Silveira TR. Hepatitis A acute liver failure: follow-up of paediatric patients in southern Brazil. J Viral Hepat. 2008;15 Suppl 2:66–8.PubMedGoogle Scholar
  160. 160.
    Hann JN, Warnock TH, Shepherd RW, et al. Fulminant hepatitis A in indigenous children in north Queensland. Med J Aust. 2000;172:19–21.Google Scholar
  161. 161.
    Thapa R, Biswas B, Mallick D, Mukherjee S. Pharyngeal-cervical-brachial variant of pediatric Guillain-Barré syndrome with antecedent acute hepatitis A virus infection. J Child Neurol. 2009;24(7):865–7.PubMedGoogle Scholar
  162. 162.
    Thapa R, Ghosh A, Mukherjee S. Childhood hepatitis A virus infection complicated by pseudotumor cerebri. South Med J. 2009;102(2):204–5.PubMedGoogle Scholar
  163. 163.
    Kano Y, Kokaji T, Shiohara T. Photo-accentuated eruption and vascular deposits of immunoglobulin A associated with hepatitis A virus infection. Dermatology. 2000;200:266–9.PubMedGoogle Scholar
  164. 164.
    Jindal M, Rana SS, Gupta RK, Das K, Kar P. Serological study of hepatitis A virus infection amongst the students of a medical college in Delhi and evaluation of the need of vaccination. Indian J Med Res. 2002;115:1–4.PubMedGoogle Scholar
  165. 165.
    Shao ZJ, Xu DZ, Yan YP, Li JH, Zhang JX, Zhang ZY, et al. Detection of anti-HAV antibody with dot immunogold filtration assay. World J Gastroenterol. 2003;9:1508–11.PubMedGoogle Scholar
  166. 166.
    Stapleton JT. Host immune response to hepatitis A virus. J Infect Dis. 1995;171:S9–14.PubMedGoogle Scholar
  167. 167.
    Wiedmann M, Boehm S, Schumacher W, Swysen C, Zauke M. Evaluation of three commercial assays for the detection of hepatitis A virus. Eur J Clin Microbiol Infect Dis. 2003;22:129–30.PubMedGoogle Scholar
  168. 168.
    Lemon SM. Immunologic approaches to assessing the response to inactivated hepatitis A vaccine. J Hepatol. 1993;18 Suppl 2:S15–9.PubMedGoogle Scholar
  169. 169.
    Siegl G, deChastonay J, Kronauer G. Propagation and assay of hepatitis A virus in vitro. J Virol Methods. 1984;9:53–67.PubMedGoogle Scholar
  170. 170.
    Nainan OV, Xia G, Vaughan G, Margolis HS. Diagnosis of hepatitis a virus infection: a molecular approach. Clin Microbiol Rev. 2006;19(1):63–79.PubMedGoogle Scholar
  171. 171.
    Provost PJ, Wolanski BS, Miller WJ, Ittensohn OL, McAleer WJ, Hilleman MR. Physical, chemical and morphologic dimensions of human hepatitis A virus strain CR326 (38578). Proc Soc Exp Biol Med. 1975;148:532–9.PubMedGoogle Scholar
  172. 172.
    Seelig R, Pott G, Seelig HP, Liehr H, Metzger P, Waldherr R. Virus-binding activity of fibronectin: masking of hepatitis A virus. J Virol Methods. 1984;8:335–47.PubMedGoogle Scholar
  173. 173.
    Margolis HS, Nainan OV. Identification of virus components in circulating immune complexes isolated during hepatitis A virus infection. Hepatology. 1990;11:31–7.PubMedGoogle Scholar
  174. 174.
    Jothikumar N, Paulmurugan R, Padmanabhan P, Sundari RB, Kamatchiammal S, Rao KS. Duplex RT-PCR for simultaneous detection of hepatitis A and hepatitis E virus isolated from drinking water samples. J Environ Monit. 2000;2:587–90.PubMedGoogle Scholar
  175. 175.
    Costa-Mattioli M, Monpoeho S, Nicand E, Aleman MH, Billaudel S, Ferre V. Quantification and duration of viraemia during hepatitis A infection as determined by real-time RT-PCR. J Viral Hepat. 2002;9:101–6.PubMedGoogle Scholar
  176. 176.
    Robertson BH, Jia XY, Tian H, et al. Antibody response to nonstructural proteins of hepatitis A virus following infection. J Med Virol. 1993;40:76–82.PubMedGoogle Scholar
  177. 177.
    Amado LA, Villar LM, de Paula VS, Gaspar AM. Comparison between serum and saliva for the detection of hepatitis A virus RNA. J Virol Methods. 2008;148(1–2):74–80.PubMedGoogle Scholar
  178. 178.
    Desbois D, Roque-Afonso AM, Lebraud P, Dussaix E. Use of dried serum spots for serological and molecular detection of hepatitis A virus. J Clin Microbiol. 2009;47(5):1536–42.PubMedGoogle Scholar
  179. 179.
    Koopmans M, von Bonsdorff CH, Vinje J, de Medici D, Monroe S. Foodborne viruses. FEMS Microbiol Rev. 2002;26:187–205.PubMedGoogle Scholar
  180. 180.
    Jiang X, Estes MK, Metcalf TG. Detection of hepatitis A virus by hybridization with single-stranded RNA probes. Appl Environ Microbiol. 1987;53:2487–95.PubMedGoogle Scholar
  181. 181.
    O’Grady J. Management of acute and fulminant hepatitis A. Vaccine. 1992;10 Suppl 1:S21–3.PubMedGoogle Scholar
  182. 182.
    Gane E, Sallie R, Saleh M, et al. Clinical recurrence of hepatitis A following liver transplantation for acute liver failure. J Med Virol. 1995;45:35–9.PubMedGoogle Scholar
  183. 183.
    Mijch AM, Gust ID. Clinical, serologic, and epidemiologic aspects of hepatitis A virus infection. Semin Liver Dis. 1986;6:42–5.PubMedGoogle Scholar
  184. 184.
    Petrosillo N, Raffaele B, Martini L, et al. A nosocomial and occupational cluster of hepatitis A virus infection in a pediatric ward. Infect Control Hosp Epidemiol. 2002;23:343–5.PubMedGoogle Scholar
  185. 185.
    Smallwood LA, Tabor E, Finlayson JS, et al. Antibodies to hepatitis A virus in immune serum globulin (Letter). Lancet. 1980;2:482–3.PubMedGoogle Scholar
  186. 186.
    Stokes J, Neefe JR. The prevention and attenuation of infectious hepatitis by gamma globulin. JAMA. 1945;127:144–5.Google Scholar
  187. 187.
    Liu JP, Nikolova D, Fei Y. Immunoglobulins for preventing hepatitis A. Cochrane Database Syst Rev. 2009;(2):CD004181.Google Scholar
  188. 188.
    Lemon SM. Type A viral hepatitis. New developments in an old disease. N Engl J Med. 1985;313:1059–67.PubMedGoogle Scholar
  189. 189.
    Victor JC, Monto AS, Surdina TY, Suleimenova SZ, Vaughan G, Nainan OV, et al. Hepatitis A vaccine versus immune globulin for postexposure prophylaxis. N Engl J Med. 2007;357(17):1685–94.PubMedGoogle Scholar
  190. 190.
    Centers for Disease Control and Prevention (CDC); Advisory Committee on Immunization Practices. Updated recommendations from the Advisory Committee on Immunization Practices (ACIP) for use of hepatitis A vaccine in close contacts of newly arriving international adoptees. MMWR Morb Mortal Wkly Rep. 2009;58(36):1006–7.Google Scholar
  191. 191.
    Shen YG, Gu XJ, Zhou JH. Protective effect of inactivated hepatitis A vaccine against the outbreak of hepatitis A in an open rural community. World J Gastroenterol. 2008;14(17):2771–5.PubMedGoogle Scholar
  192. 192.
    Hammitt LL, Bulkow L, Hennessy TW, Zanis C, Snowball M, Williams JL, et al. Persistence of antibody to hepatitis A virus 10 years after vaccination among children and adults. J Infect Dis. 2008;198(12):1776–82.PubMedGoogle Scholar
  193. 193.
    Dagan R, Amir J, Mijalovsky A, et al. Immunization against hepatitis A in the first year of life: priming despite the presence of maternal antibody. Pediatr Infect Dis J. 2000;19:1045–52.PubMedGoogle Scholar
  194. 194.
    Lemon SM, Murphy PC, Provost PJ, et al. Immunoprecipitation and virus neutralization assays demonstrate qualitative differences between protective antibody responses to inactivated hepatitis A vaccine and passive immunization with immune globulin. J Infect Dis. 1997;176:9–19.PubMedGoogle Scholar
  195. 195.
    Overton ET, Nurutdinova D, Sungkanuparph S, Seyfried W, Groger RK, Powderly WG. Predictors of immunity after hepatitis A vaccination in HIV-infected persons. J Viral Hepat. 2007;14(3):189–93.PubMedGoogle Scholar
  196. 196.
    Weinberg A, Huang S, Fenton T, Patterson-Bartlett J, Gona P, Read JS, et al. Virologic and immunologic correlates with the magnitude of antibody responses to the hepatitis A vaccine in HIV-infected children on highly active antiretroviral treatment. J Acquir Immune Defic Syndr. 2009;52:17–24.PubMedGoogle Scholar
  197. 197.
    Bell BP. Hepatitis A vaccine. Semin Pediatr Infect Dis. 2002;13:165–73.PubMedGoogle Scholar
  198. 198.
    Midthun K, Ellerbeck E, Gershman K, Calandra G, Krah D, McCaughtry M, et al. Safety and immunogenicity of a live attenuated hepatitis A virus vaccine in seronegative volunteers. J Infect Dis. 1991;163:735–9.PubMedGoogle Scholar
  199. 199.
    Faridi MM, Shah N, Ghosh TK, Sankaranarayanan VS, Arankalle V, Aggarwal A, et al. Immunogenicity and safety of live attenuated hepatitis A vaccine: a multicentric study. Indian Pediatr. 2009;46(1):29–34.PubMedGoogle Scholar
  200. 200.
    Wang XY, Xub Z, Xing Y, Tian M, Zhoub L, Hea L, et al. Immune responses of anti-HAV in children vaccinated with live attenuated and inactivated hepatitis A vaccines. Vaccine. 2004;22:1941–5.PubMedGoogle Scholar
  201. 201.
    Lemon SM, Murphy PC, Provost PJ, Chalikonda I, Davide JP, Schofield TL, et al. Immunoprecipitation and virus neutralization assays demonstrate qualitative differences between protective antibody responses to inactivated hepatitis A vaccine and passive immunization with immune globulin. J Infect Dis. 1997;176:9–19.PubMedGoogle Scholar
  202. 202.
    Wasley A, Samandari T, Bell BP. Incidence of hepatitis A in the United States in the era of vaccination. JAMA. 2005;294:194–201.PubMedGoogle Scholar
  203. 203.
    Rein DB, Hicks KA, Wirth KE, Billah K, Finelli L, Fiore AE, et al. Cost-effectiveness of routine childhood vaccination for hepatitis A in the United States. Pediatrics. 2007;119(1):e12–21.PubMedGoogle Scholar
  204. 204.
    Lopez E, Debbag R, Coudeville L, Baron-Papillon F, Armoni J. The cost-effectiveness of universal vaccination of children against hepatitis A in Argentina: results of a dynamic health-economic analysis. J Gastroenterol. 2007;42(2):152–60.PubMedGoogle Scholar
  205. 205.
    Chodick G, Green MS, Heymann AD, Rosenmann L, Shalev V. The shifting epidemiology of hepatitis A following routine childhood immunization program in Israel. Prev Med. 2007;45(5):386–91.PubMedGoogle Scholar
  206. 206.
    Domínguez A, Oviedo M, Carmona G, Batalla J, Bruguera M, Salleras L, et al. Impact and effectiveness of a mass hepatitis A vaccination programme of preadolescents seven years after introduction. Vaccine. 2008;26(14):1737–41.PubMedGoogle Scholar
  207. 207.
    Teppakdee A, Tangwitoon A, Khemasuwan D, Tangdhanakanond K, Suramaethakul N, Sriratanaban J, et al. Cost-benefit analysis of hepatitis a vaccination in Thailand. Southeast Asian J Trop Med Public Health. 2002;33:118–27.PubMedGoogle Scholar
  208. 208.
    Rose SR, Keystone JS. Hepatitis. In: International Travel Health Guide: 2007 Online Edition. At www.travmed.com/health_guide/ch12.htm. Accessed 14 January 2010.

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of GastroenterologyG.B. Pant HospitalNew DelhiIndia
  2. 2.Institute of Liver and Biliary SciencesNew DelhiIndia

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