Alcoholic Liver Disease

  • Samuel W. French
Part of the Molecular Pathology Library book series (MPLB, volume 5)


Alcoholic liver disease (ALD) remains a significant health burden in the USA and worldwide. The histological spectrum of this disease spans from simple steatosis to steatohepatitis (characterized by inflammatory cell infiltration, hepatocyte ballooning, apoptosis, and necrosis in addition to fat accumulation) to fibrosis and overt cirrhosis. Steatosis in this setting is mainly macrovesicular and most prominent in the centrilobular region or zone 3. Early stages of alcohol-induced liver injury are reversible and prevention of steatosis in experimental models has been shown to prevent progression to inflammation and fibrosis.


Fatty Liver Stellate Cell Alcoholic Liver Disease Chronic Ethanol Alcoholic Hepatitis 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Division of Anatomic Pathology, Department of PathologyHarbor UCLA Medical CenterTorranceUSA

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