Oxidative Stress and Liver Injury

  • Francisco Javier Cubero
  • Christian Trautwein
Part of the Molecular Pathology Library book series (MPLB, volume 5)


Oxidative stress and liver injury are strongly associated. Oxidative stress in the liver can be triggered during different conditions and by specific etiologies, including hepatotoxins (acetaminophen [1]), viruses (e.g., hepatitis C virus [2]), nonalcoholic steatohepatitis (NASH) [3], hepatocellular carcinoma [4], alcoholic liver disease (ALD) [5], ischemia-­reperfusion, and liver fibrosis [6]. Oxidative stress is a state of imbalance between the production of reactive oxygen species (ROS) and the cellular antioxidant defense neutralizing the reactive intermediates and triggering damage.


Reactive Oxygen Species Liver Injury Kupffer Cell Alcoholic Liver Disease Nonalcoholic Fatty Liver Disease 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Internal Medicine IIIUniversity Hospital Aachen (RTWH)AachenGermany

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