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Hepatic Tissue Engineering

  • Jing Shan
  • Kelly R. Stevens
  • Kartik Trehan
  • Gregory H. Underhill
  • Alice A. Chen
  • Sangeeta N. Bhatia
Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 5)

Abstract

Liver tissue engineering aims to provide novel therapies for liver diseases and create effective tools for understanding fundamental aspects of liver biology and pathologic processes. Approaches range from bio-mimetic in vitro model systems of the liver to three-dimensional implantable constructs. Collectively, these cell-based approaches endeavor to replace or enhance organ transplantation, which is the current standard treatment for liver diseases in most clinical settings. However, the complexity of liver structure and function as well as the limited supply of human hepatocytes pose unique challenges for the field. This chapter reviews advances in the field of liver tissue engineering within the context of current therapies for liver diseases, and clinical alternatives such as cell transplantation strategies and extracorporeal bioartificial liver devices.

Keywords

Human Hepatocyte Primary Hepatocyte PLGA Scaffold Spheroid Culture Hepatic Progenitor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgement

Funding provided by NIH R01-DK065152 and NIH R01-DK56966.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Jing Shan
  • Kelly R. Stevens
  • Kartik Trehan
  • Gregory H. Underhill
  • Alice A. Chen
  • Sangeeta N. Bhatia
    • 1
  1. 1.M.I.T.CambridgeUSA

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