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Hepatocyte Transplantation

  • Mirela-Patricia Sirbu-Boeti
  • Kyle Soltys
  • Alejandro Soto-Gutierrez
  • Ira J. Fox
Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 5)

Abstract

The scientific foundation for clinical hepatocyte transplantation was developed over the last 40 years by extensive laboratory work in animals. The first attempts at human hepatocyte transplantation were performed by Mito et al. who used autologous hepatocytes to treat patients with chronic liver disease [1]. Habibullah et al. [2] later transplanted allogeneic fetal hepatocytes to treat patients with fulminant hepatic failure. The first attempted treatment of a metabolic disorder was performed in patients with familial hypercholesterolemia using autologous retrovirus-transduced hepatocytes by Grossman et al. [3]. Several years later, allogenic hepatocytes were used to treat a different metabolic liver disorder with some success in a patient with Crigler-Najjar syndrome type I [4].

Keywords

Orthotopic Liver Transplantation Biliary Atresia Acute Liver Failure Familial Hypercholesterolemia Fetal Liver Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Mirela-Patricia Sirbu-Boeti
  • Kyle Soltys
  • Alejandro Soto-Gutierrez
  • Ira J. Fox
    • 1
  1. 1.Department of SurgeryUniversity of PittsburghPittsburghUSA

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