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Hepatic Progenitors in Development and Transplantation

  • David A. Shafritz
  • Michael Oertel
  • Mariana D. Dabeva
Chapter
Part of the Molecular Pathology Library book series (MPLB, volume 5)

Abstract

The rationale for studies to repopulate the liver with transplanted cells is essentially based on three observations: (1) The well-known finding that the liver can fully regenerate after acute hepatotoxic injury or surgical reduction in liver mass, (2) the regenerated liver functions normally, without long-term impairment, and (3) a unique portal (venous to venous) circulation exists in the liver that provides ready access of transplanted cells to the parenchyma through the hepatic sinusoids.

Keywords

Oval Cell Partial Hepatectomy Fetal Liver Fetal Liver Cell Hepatic Progenitor Cell 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgements

The authors would like to thank Anna Caponigro and Emily Bobe for assistance in typing this manuscript.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • David A. Shafritz
    • 1
  • Michael Oertel
  • Mariana D. Dabeva
  1. 1.Department of Medicine, Cell Biology and Pathology, Marion Bessin Liver Research CenterAlbert Einstein College of Medicine of Yeshiva UniversityNew YorkUSA

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