Transcriptional Control of Hepatocyte Differentiation

  • Joseph Locker
Part of the Molecular Pathology Library book series (MPLB, volume 5)


The unique gene expression that defines the hepatocyte conforms to a set of general regulatory principles. The genome encodes the programs of mature gene expression and of the preceding developmental stages. Transcription factors execute these programs by binding to specific DNA sequence motifs grouped together as promoters and enhancers. Expression of each gene therefore reflects the synergistic integration of separate regulations via individual factors. Each cell type expresses a distinctive mixture of hundreds of transcription factors. This mixture, superimposed on the epigenetic history of the cell, determines its phenotype.


Bile Acid Nuclear Receptor Constitutive Androstane Receptor Mature Liver C2H2 Zinc Finger 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of PathologyAlbert Einstein College of MedicineNew YorkUSA

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