Liver Development

  • Klaus H. Kaestner
Part of the Molecular Pathology Library book series (MPLB, volume 5)


About 5% of the body mass of mammals is made up by the liver, our largest internal organ. Absence of the liver is not compatible with life, due to the multiple essential metabolic functions of the organ. In addition, multiple diseases are caused wholly or in part by impaired liver function. Examples of the impressive functional diversity of the liver, which are discussed in detail elsewhere in this volume, are the secretion of serum components and clotting factors, the regulation of glucose, protein and lipid metabolism, and the detoxification of xenobiotics, drugs, and other chemicals.


Gene Expression Program Linker Histone Liver Development Foxa Gene Transcription Factor Network 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of GeneticsUniversity of Pennsylvania School of MedicinePhiladelphiaUSA

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