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Implications of Human Microbiome Research for the Developing World

  • Appolinaire Djikeng
  • Barbara Jones Nelson
  • Karen E. Nelson
Chapter

Abstract

The human microbiome refers to all of the species that inhabit the human body, residing both on and in it. Over the past several years, there has been a significantly increased interest directed to the understanding of the microorganisms that reside on and in the human body. These studies of the human microbiome promise to reveal all these species and increase our understanding of the normal inhabitants, those that trigger disease and those that vary in response to disease conditions. It is anticipated that these directed research efforts, coupled with new technological advances, will ultimately allow one to gain a greater understanding of the relationships of these species with their human hosts. The various chapters in this book present a range of aspects of human microbiome research, explain the scientific and technological rationale, and highlight the significant potential that the results from these studies hold. In this chapter, we begin to address the potential and long-term implications of the knowledge gained from human microbiome research (which currently is centered in the developed world) for the developing world, which has often lagged behind in the benefits of these new technologies and their implications to new research areas.

Keywords

Severe Acute Respiratory Syndrome Bacterial Vaginosis Diarrheal Disease Severe Acute Respiratory Syndrome Human Microbiome 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

Notes

Acknowledgement

The authors wish to acknowledge the invaluable information found on the World Health Organisation (WHO) website and on the Mayo Clinic website.

References

  1. Atashili J, Poole C, Ndumbe PM, Adimora AA and Smith JS (2008) Bacterial vaginosis and HIV acquisition: a meta-analysis of published studies. AIDS 22:1493–1501PubMedCentralPubMedCrossRefGoogle Scholar
  2. Bentley S (2009) Sequencing the species pan-genome. Nat Rev Microbiol 7:258–259PubMedCrossRefGoogle Scholar
  3. Berriman M, Ghedin E, Hertz-Fowler C, Blandin G, Renauld H, Bartholomeu DC, Lennard NJ, Caler E, Hamlin NE, Haas B, Bohme U, Hannick L, Aslett MA, Shallom J, Marcello L, Hou L, Wickstead B, Alsmark UC, Arrowsmith C, Atkin RJ, Barron AJ, Bringaud F, Brooks K, Carrington M, Cherevach I, Chillingworth TJ, Churcher C, Clark LN, Corton CH, Cronin A, Davies RM, Doggett J, Djikeng A, Feldblyum T, Field MC, Fraser A, Goodhead I, Hance Z, Harper D, Harris BR, Hauser H, Hostetler J, Ivens A, Jagels K, Johnson D, Johnson J, Jones K, Kerhornou AX, Koo H, Larke N, Landfear S, Larkin C, Leech V, Line A, Lord A, Macleod A, Mooney PJ, Moule S, Martin DM, Morgan GW, Mungall K, Norbertczak H, Ormond D, Pai G, Peacock CS, Peterson J, Quail MA, Rabbinowitsch E, Rajandream MA, Reitter C, Salzberg SL, Sanders M, Schobel S, Sharp S, Simmonds M, Simpson AJ, Tallon L, Turner CM, Tait A, Tivey AR, Van Aken S, Walker D, Wanless D, Wang S, White B, White O, Whitehead S, Woodward J, Wortman J, Adams MD, Embley TM, Gull K, Ullu E, Barry JD, Fairlamb AH, Opperdoes F, Barrell BG, Donelson JE, Hall N, Fraser CM, Melville SE and El-Sayed NM (2005) The genome of the African trypanosome Trypanosoma brucei. Science 309:416–422PubMedCrossRefGoogle Scholar
  4. Bhatia R, Narain JP (2009) Re-emerging chikungunya fever: some lessons from Asia. Trop Med Int Health 14:940–946PubMedCrossRefGoogle Scholar
  5. Bik EM, Eckburg PB, Gill SR, Nelson KE, Purdom EA, Francois F, Perez-Perez G, Blaser MJ, Relman DA (2006) Molecular analysis of the bacterial microbiota in the human stomach. Proc Natl Acad Sci USA 103:732–737PubMedCentralPubMedCrossRefGoogle Scholar
  6. Bishop R, Shah T, Pelle R, Hoyle D, Pearson T, Haines L, Brass A, Hulme H, Graham SP, Taracha EL, Kanga S, Lu C, Hass B, Wortman J, White O, Gardner MJ, Nene V, de Villiers EP (2005) Analysis of the transcriptome of the protozoan Theileria parva using MPSS reveals that the majority of genes are transcriptionally active in the schizont stage. Nucleic Acids Res 33:5503–5511PubMedCentralPubMedCrossRefGoogle Scholar
  7. Callister SJ, McCue LA, Turse JE, Monroe ME, Auberry KJ, Smith RD, Adkins JN, Lipton MS (2008) Comparative bacterial proteomics: analysis of the core genome concept. PLoS One 3:e1542PubMedCentralPubMedCrossRefGoogle Scholar
  8. Carlton JM, Adams JH, Silva JC, Bidwell SL, Lorenzi H, Caler E, Crabtree J, Angiuoli SV, Merino EF, Amedeo P, Cheng Q, Coulson RM, Crabb BS, Del Portillo HA, Essien K, Feldblyum TV, Fernandez-Becerra C, Gilson PR, Gueye AH, Guo X, Kang’a S, Kooij TW, Korsinczky M, Meyer EV, Nene V, Paulsen I, White O, Ralph SA, Ren Q, Sargeant TJ, Salzberg SL, Stoeckert CJ, Sullivan SA, Yamamoto MM, Hoffman SL, Wortman JR, Gardner MJ, Galinski MR, Barnwell JW, Fraser-Liggett CM (2008) Comparative genomics of the neglected human malaria parasite Plasmodium vivax. Nature 455:757–763PubMedCentralPubMedCrossRefGoogle Scholar
  9. Chain PS, Grafham DV, Fulton RS, Fitzgerald MG, Hostetler J, Muzny D, Ali J, Birren B, Bruce DC, Buhay C, Cole JR, Ding Y, Dugan S, Field D, Garrity GM, Gibbs R, Graves T, Han CS, Harrison SH, Highlander S, Hugenholtz P, Khouri HM, Kodira CD, Kolker E, Kyrpides NC, Lang D, Lapidus A, Malfatti SA, Markowitz V, Metha T, Nelson KE, Parkhill J, Pitluck S, Qin X, Read TD, Schmutz J, Sozhamannan S, Sterk P, Strausberg RL, Sutton G, Thomson NR, Tiedje JM, Weinstock G, Wollam A, Detter JC (2009) Genomics. Genome project standards in a new era of sequencing. Science 326:236–237PubMedCrossRefGoogle Scholar
  10. Coloma J, Harris E (2009) Molecular genomic approaches to infectious diseases in resource-limited settings. PLoS Med 6:e1000142PubMedCentralPubMedCrossRefGoogle Scholar
  11. Costello EK, Lauber CL, Hamady M, Fierer N, Gordon JI and Knight R (2009) Bacterial community variation in human body habitats across space and time. Science 326:1694–1697Google Scholar
  12. Culligan EP, Hill C, Sleator RD (2009) Probiotics and gastrointestinal disease: successes, problems and future prospects. Gut Pathog 1:19PubMedCentralPubMedCrossRefGoogle Scholar
  13. De Schryver A, Meheus A (1990) Epidemiology of sexually transmitted diseases: the global picture. Bull World Health Organ 68:639–654PubMedCentralPubMedGoogle Scholar
  14. Dorer MS, Talarico S, Salama NR (2009) Helicobacter pylori’s unconventional role in health and disease. PLoS Pathog 5:e1000544PubMedCentralPubMedCrossRefGoogle Scholar
  15. Eckburg PB, Bik EM, Bernstein CN, Purdom E, Dethlefsen L, Sargent M, Gill SR, Nelson KE, Relman DA (2005) Diversity of the human intestinal microbial flora. Science 308:1635–1638PubMedCentralPubMedCrossRefGoogle Scholar
  16. El-Sayed NM, Myler PJ, Blandin G, Berriman M, Crabtree J, Aggarwal G, Caler E, Renauld H, Worthey EA, Hertz-Fowler C, Ghedin E, Peacock C, Bartholomeu DC, Haas BJ, Tran AN, Wortman JR, Alsmark UC, Angiuoli S, Anupama A, Badger J, Bringaud F, Cadag E, Carlton JM, Cerqueira GC, Creasy T, Delcher AL, Djikeng A, Embley TM, Hauser C, Ivens AC, Kummerfeld SK, Pereira-Leal JB, Nilsson D, Peterson J, Salzberg SL, Shallom J, Silva JC, Sundaram J, Westenberger S, White O, Melville SE, Donelson JE, Andersson B, Stuart KD, Hall N (2005) Comparative genomics of trypanosomatid parasitic protozoa. Science 309:404–409PubMedCrossRefGoogle Scholar
  17. Field HE (2009) Bats and emerging zoonoses: henipaviruses and SARS. Zoonoses Public Health 2009-May 28thGoogle Scholar
  18. Finkbeiner SR, Allred AF, Tarr PI, Klein EJ, Kirkwood CD, Wang D (2008) Metagenomic analysis of human diarrhea: viral detection and discovery. PLoS Pathog 4:e1000011PubMedCentralPubMedCrossRefGoogle Scholar
  19. Foster JA, Krone SM, Forney LJ (2008) Application of ecological network theory to the human microbiome. Interdiscip Perspect Infect Dis 2008:839501PubMedCentralPubMedGoogle Scholar
  20. Gao Z, Tseng CH, Pei Z, Blaser MJ (2007) Molecular analysis of human forearm superficial skin bacterial biota. Proc Natl Acad Sci USA 104:2927–2932PubMedCentralPubMedCrossRefGoogle Scholar
  21. Gao Z, Tseng CH, Strober BE, Pei Z, Blaser MJ (2008) Substantial alterations of the cutaneous bacterial biota in psoriatic lesions. PLoS One 3:e2719PubMedCentralPubMedCrossRefGoogle Scholar
  22. Gardner MJ, Bishop R, Shah T, de Villiers EP, Carlton JM, Hall N, Ren Q, Paulsen IT, Pain A, Berriman M, Wilson RJ, Sato S, Ralph SA, Mann DJ, Xiong Z, Shallom SJ, Weidman J, Jiang L, Lynn J, Weaver B, Shoaibi A, Domingo AR, Wasawo D, Crabtree J, Wortman JR, Haas B, Angiuoli SV, Creasy TH, Lu C, Suh B, Silva JC, Utterback TR, Feldblyum TV, Pertea M, Allen J, Nierman WC, Taracha EL, Salzberg SL, White OR, Fitzhugh HA, Morzaria S, Venter JC, Fraser CM, Nene V (2005) Genome sequence of Theileria parva, a bovine pathogen that transforms lymphocytes. Science 309:134–137PubMedCrossRefGoogle Scholar
  23. Gardner MJ, Hall N, Fung E, White O, Berriman M, Hyman RW, Carlton JM, Pain A, Nelson KE, Bowman S, Paulsen IT, James K, Eisen JA, Rutherford K, Salzberg SL, Craig A, Kyes S, Chan MS, Nene V, Shallom SJ, Suh B, Peterson J, Angiuoli S, Pertea M, Allen J, Selengut J, Haft D, Mather MW, Vaidya AB, Martin DM, Fairlamb AH, Fraunholz MJ, Roos DS, Ralph SA, McFadden GI, Cummings LM, Subramanian GM, Mungall C, Venter JC, Carucci DJ, Hoffman SL, Newbold C, Davis RW, Fraser CM, Barrell B (2002) Genome sequence of the human malaria parasite Plasmodium falciparum. Nature 419:498–511PubMedCrossRefGoogle Scholar
  24. Gibbs AJ, Armstrong JS, Downie JC (2009) From where did the 2009 ‘swine-origin’ influenza A virus (H1N1) emerge? Virol J 6:207PubMedCentralPubMedCrossRefGoogle Scholar
  25. Gill SR, Pop M, Deboy RT, Eckburg PB, Turnbaugh PJ, Samuel BS, Gordon JI, Relman DA, Fraser-Liggett CM, Nelson KE (2006) Metagenomic analysis of the human distal gut microbiome. Science 312:1355–1359PubMedCentralPubMedCrossRefGoogle Scholar
  26. Grice EA, Kong HH, Conlan S, Deming CB, Davis J, Young AC, Bouffard GG, Blakesley RW, Murray PR, Green ED, Turner ML, Segre JA (2009) Topographical and temporal diversity of the human skin microbiome. Science 324:1190–1192PubMedCentralPubMedCrossRefGoogle Scholar
  27. Holtz LR, Finkbeiner SR, Kirkwood CD, Wang D (2008) Identification of a novel picornavirus related to cosaviruses in a child with acute diarrhea. Virol J 5:159PubMedCentralPubMedCrossRefGoogle Scholar
  28. Kim TK, Thomas SM, Ho M, Sharma S, Reich CI, Frank JA, Yeater KM, Biggs DR, Nakamura N, Stumpf R, Leigh SR, Tapping RI, Blanke SR, Slauch JM, Gaskins HR, Weisbaum JS, Olsen GJ, Hoyer LL, Wilson BA (2009) Heterogeneity of vaginal microbial communities within individuals. J Clin Microbiol 47:1181–1189PubMedCentralPubMedCrossRefGoogle Scholar
  29. Kudva IT, Evans PS, Perna NT, Barrett TJ, Ausubel FM, Blattner FR, Calderwood SB (2002) Strains of Escherichia coli O157:H7 differ primarily by insertions or deletions, not single-nucleotide polymorphisms. J Bacteriol 184:1873–1879PubMedCentralPubMedCrossRefGoogle Scholar
  30. Lasken RS (2009) Genomic DNA amplification by the multiple displacement amplification (MDA) method. Biochem Soc Trans 37:450–453PubMedCrossRefGoogle Scholar
  31. Mahmoud A, Zerhouni E (2009) Neglected tropical diseases: moving beyond mass drug treatment to understanding the science. Health Aff (Millwood) 28:1726–1733CrossRefGoogle Scholar
  32. Manichanh C, Rigottier-Gois L, Bonnaud E, Gloux K, Pelletier E, Frangeul L, Nalin R, Jarrin C, Chardon P, Marteau P, Roca J, Dore J (2006) Reduced diversity of faecal microbiota in Crohn’s disease revealed by a metagenomic approach. Gut 55:205–211PubMedCentralPubMedCrossRefGoogle Scholar
  33. Martin HL, Richardson BA, Nyange PM, Lavreys L, Hillier SL, Chohan B, Mandaliya K, Ndinya-Achola JO, Bwayo J, Kreiss J (1999) Vaginal lactobacilli, microbial flora, and risk of human immunodeficiency virus type 1 and sexually transmitted disease acquisition. J Infect Dis 180:1863–1868PubMedCrossRefGoogle Scholar
  34. Matthijnssens J, Bilcke J, Ciarlet M, Martella V, Banyai K, Rahman M, Zeller M, Beutels P, Van Damme P, Van Ranst M (2009) Rotavirus disease and vaccination: impact on genotype diversity. Future Microbiol 4:1303–1316PubMedCrossRefGoogle Scholar
  35. Mitsui H, Arisue N, Sakihama N, Inagaki Y, Horii T, Hasegawa M, Tanabe K, Hashimoto T (2009) Phylogeny of Asian primate malaria parasites inferred from apicoplast genome-encoded genes with special emphasis on the positions of Plasmodium vivax and P. fragile. Gene 2010, Gene 450:32–38Google Scholar
  36. Mullard A (2008) Microbiology: the inside story. Nature 453:578–580PubMedCrossRefGoogle Scholar
  37. Nealson KH, Venter JC (2007) Metagenomics and the global ocean survey: what’s in it for us, and why should we care? ISME J 1:185–187PubMedCrossRefGoogle Scholar
  38. Nene V, Bishop R, Morzaria S, Gardner MJ, Sugimoto C, ole-MoiYoi OK, Fraser CM, Irvin A (2000) Theileria parva genomics reveals an atypical apicomplexan genome. Int J Parasitol 30:465–474PubMedCrossRefGoogle Scholar
  39. Pain A, Bohme U, Berry AE, Mungall K, Finn RD, Jackson AP, Mourier T, Mistry J, Pasini EM, Aslett MA, Balasubrammaniam S, Borgwardt K, Brooks K, Carret C, Carver TJ, Cherevach I, Chillingworth T, Clark TG, Galinski MR, Hall N, Harper D, Harris D, Hauser H, Ivens A, Janssen CS, Keane T, Larke N, Lapp S, Marti M, Moule S, Meyer IM, Ormond D, Peters N, Sanders M, Sanders S, Sargeant TJ, Simmonds M, Smith F, Squares R, Thurston S, Tivey AR, Walker D, White B, Zuiderwijk E, Churcher C, Quail MA, Cowman AF, Turner CM, Rajandream MA, Kocken CH, Thomas AW, Newbold CI, Barrell BG, Berriman M (2008) The genome of the simian and human malaria parasite Plasmodium knowlesi. Nature 455:799–803PubMedCentralPubMedCrossRefGoogle Scholar
  40. Perna NT, Plunkett G 3rd, Burland V, Mau B, Glasner JD, Rose DJ, Mayhew GF, Evans PS, Gregor J, Kirkpatrick HA, Posfai G, Hackett J, Klink S, Boutin A, Shao Y, Miller L, Grotbeck EJ, Davis NW, Lim A, Dimalanta ET, Potamousis KD, Apodaca J, Anantharaman TS, Lin J, Yen G, Schwartz DC, Welch RA, Blattner FR (2001) Genome sequence of enterohaemorrhagic Escherichia coli O157:H7. Nature 409:529–533PubMedCrossRefGoogle Scholar
  41. Peterson J, Garges S, Giovanni M, McInnes P, Wang L, Schloss JA, Bonazzi V, McEwen JE, Wetterstrand KA, Deal C, Baker CC, Di Francesco V, Howcroft TK, Karp RW, Lunsford RD, Wellington CR, Belachew T, Wright M, Giblin C, David H, Mills M, Salomon R, Mullins C, Akolkar B, Begg L, Davis C, Grandison L, Humble M, Khalsa J, Little AR, Peavy H, Pontzer C, Portnoy M, Sayre MH, Starke-Reed P, Zakhari S, Read J, Watson B, Guyer M (2009) The NIH human microbiome project. Genome Res 19(12):2317–2323Google Scholar
  42. Picardeau M, Bulach DM, Bouchier C, Zuerner RL, Zidane N, Wilson PJ, Creno S, Kuczek ES, Bommezzadri S, Davis JC, McGrath A, Johnson MJ, Boursaux-Eude C, Seemann T, Rouy Z, Coppel RL, Rood JI, Lajus A, Davies JK, Medigue C, Adler B (2008) Genome sequence of the saprophyte Leptospira biflexa provides insights into the evolution of Leptospira and the pathogenesis of leptospirosis. PLoS One 3:e1607PubMedCentralPubMedCrossRefGoogle Scholar
  43. Ponnusamy L, Wesson DM, Arellano C, Schal C, Apperson CS (2009) Species composition of bacterial communities influences attraction of mosquitoes to experimental plant infusions. Microb Ecol 2010 59:158–73Google Scholar
  44. Ponnusamy L, Xu N, Nojima S, Wesson DM, Schal C, Apperson CS (2008a) Identification of bacteria and bacteria-associated chemical cues that mediate oviposition site preferences by Aedes aegypti. Proc Natl Acad Sci USA 105:9262–9267PubMedCentralPubMedCrossRefGoogle Scholar
  45. Ponnusamy L, Xu N, Stav G, Wesson DM, Schal C, Apperson CS (2008b) Diversity of bacterial communities in container habitats of mosquitoes. Microb Ecol 56:593–603PubMedCentralPubMedCrossRefGoogle Scholar
  46. Ramani S, Kang G (2009) Viruses causing childhood diarrhoea in the developing world. Curr Opin Infect Dis 22:477–482Google Scholar
  47. Reid G, Devillard E (2004) Probiotics for mother and child. J Clin Gastroenterol 38:S94–101PubMedCrossRefGoogle Scholar
  48. Reid G, Anand S, Bingham MO, Mbugua G, Wadstrom T, Fuller R, Anukam K, Katsivo M (2005) Probiotics for the developing world. J Clin Gastroenterol 39:485–488PubMedCrossRefGoogle Scholar
  49. Relman DA (2002) New technologies, human–microbe interactions, and the search for previously unrecognized pathogens. J Infect Dis 186(Suppl 2):S254–258PubMedCrossRefGoogle Scholar
  50. Rusch DB, Halpern AL, Sutton G, Heidelberg KB, Williamson S, Yooseph S, Wu D, Eisen JA, Hoffman JM, Remington K, Beeson K, Tran B, Smith H, Baden-Tillson H, Stewart C, Thorpe J, Freeman J, Andrews-Pfannkoch C, Venter JE, Li K, Kravitz S, Heidelberg JF, Utterback T, Rogers YH, Falcon LI, Souza V, Bonilla-Rosso G, Eguiarte LE, Karl DM, Sathyendranath S, Platt T, Bermingham E, Gallardo V, Tamayo-Castillo G, Ferrari MR, Strausberg RL, Nealson K, Friedman R, Frazier M, Venter JC (2007) The sorcerer II global ocean sampling expedition: northwest Atlantic through eastern tropical Pacific. PLoS Biol 5:e77PubMedCentralPubMedCrossRefGoogle Scholar
  51. Seksik P, Sokol H, Lepage P, Vasquez N, Manichanh C, Mangin I, Pochart P, Doré J, Marteau P (2006) The role of bacteria in onset and perpetuation of inflammatory bowel disease. Aliment Pharmacol Ther 24 Suppl 3:11–18PubMedCrossRefGoogle Scholar
  52. Seksik P, Cosnes J, Sokol H, Nion-Larmurier I, Gendre JP, Beaugerie L. (2009) Incidence of benign upper respiratory tract infections, HSV and HPV cutaneous infections in inflammatory bowel disease patients treated with azathioprine. Aliment Pharmacol Ther 29:1106–1113PubMedCrossRefGoogle Scholar
  53. Sokol H, Lepage P, Seksik P, Doré J, Marteau P (2006) Temperature gradient gel electrophoresis of fecal 16S rRNA reveals active Escherichia coli in the microbiota of patients with ulcerative colitis. J Clin Microbiol 44: 3172–3177PubMedCentralPubMedCrossRefGoogle Scholar
  54. 3.
    Sokol H, Lepage P, Seksik P, Doré J, Marteau P (2007) Molecular comparison of dominant microbiota associated with injured versus healthy mucosa in ulcerative colitis. Gut 56:152–154PubMedCentralPubMedCrossRefGoogle Scholar
  55. Sokol H, Pigneur B, Watterlot L, Lakhdari O, Bermudez-Humaran LG, Gratadoux JJ, Blugeon S, Bridonneau C, Furet JP, Corthier G, Grangette C, Vasquez N, Pochart P, Trugnan G, Thomas G, Blottiere HM, Dore J, Marteau P, Seksik P, Langella P (2008) Faecalibacterium prausnitzii is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients. Proc Natl Acad Sci USA 105:16731–16736PubMedCentralPubMedCrossRefGoogle Scholar
  56. Turnbaugh PJ, Backhed F, Fulton L, Gordon JI (2008) Diet-induced obesity is linked to marked but reversible alterations in the mouse distal gut microbiome. Cell Host Microbe 3:213–223PubMedCentralPubMedCrossRefGoogle Scholar
  57. Turnbaugh PJ, Hamady M, Yatsunenko T, Cantarel BL, Duncan A, Ley RE, Sogin ML, Jones WJ, Roe BA, Affourtit JP, Egholm M, Henrissat B, Heath AC, Knight R, Gordon JI (2009) A core gut microbiome in obese and lean twins. Nature 457:480–484PubMedCentralPubMedCrossRefGoogle Scholar
  58. van De Wijgert JH, Mason PR, Gwanzura L, Mbizvo MT, Chirenje ZM, Iliff V, Shiboski S, Padian NS (2000) Intravaginal practices, vaginal flora disturbances, and acquisition of sexually transmitted diseases in Zimbabwean women. J Infect Dis 181:587–594CrossRefGoogle Scholar
  59. van de Wijgert JH, Morrison CS, Cornelisse PG, Munjoma M, Moncada J, Awio P, Wang J, Van der Pol B, Chipato T, Salata RA, Padian NS (2008) Bacterial vaginosis and vaginal yeast, but not vaginal cleansing, increase HIV-1 acquisition in African women. J Acquir Immune Defic Syndr 48:203–210PubMedCrossRefGoogle Scholar
  60. Yazdanbakhsh M, Kremsner PG (2009) Influenza in Africa. PLoS Med 6:e1000182PubMedCentralPubMedCrossRefGoogle Scholar
  61. Yooseph S, Sutton G, Rusch DB, Halpern AL, Williamson SJ, Remington K, Eisen JA, Heidelberg KB, Manning G, Li W, Jaroszewski L, Cieplak P, Miller CS, Li H, Mashiyama ST, Joachimiak MP, van Belle C, Chandonia JM, Soergel DA, Zhai Y, Natarajan K, Lee S, Raphael BJ, Bafna V, Friedman R, Brenner SE, Godzik A, Eisenberg D, Dixon JE, Taylor SS, Strausberg RL, Frazier M, Venter JC (2007) The sorcerer II global ocean sampling expedition: expanding the universe of protein families. PLoS Biol 5:e16PubMedCentralPubMedCrossRefGoogle Scholar
  62. Yutin N, Suzuki MT, Teeling H, Weber M, Venter JC, Rusch DB, Beja O (2007) Assessing diversity and biogeography of aerobic anoxygenic phototrophic bacteria in surface waters of the Atlantic and Pacific Oceans using the global ocean sampling expedition metagenomes. Environ Microbiol 9:1464–1475PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  • Appolinaire Djikeng
    • 1
  • Barbara Jones Nelson
    • 2
  • Karen E. Nelson
    • 3
  1. 1.Biosciences Eastern and Central Africa (BecA), International Livestock Research Institute (ILRI)NairobiKenya
  2. 2.KentHill BiosciencesGaithersburgUSA
  3. 3.Department of Human Genomic MedicineThe J. Craig Venter InstituteRockvilleUSA

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