Meta-Analysis of Randomized Controlled Trials of Granulocyte Colony-Stimulating Factor Prophylaxis in Adult Cancer Patients Receiving Chemotherapy

Chapter
Part of the Cancer Treatment and Research book series (CTAR, volume 157)

Abstract

Granulocyte colony-stimulating factor (G-CSF) reduces the severity and duration of neutropenia associated with cancer chemotherapy [1–5]. In the pivotal phase III trial in patients with small cell lung cancer, patients were randomized to either G-CSF or placebo following combination chemotherapy in a double-blind fashion [3]. A significant difference in the cumulative risk of febrile neutropenia (FN) between the control (77%) and the G-CSF (40%) groups was observed despite the allowed use of secondary G-CSF prophylaxis after an initial occurrence of FN in the control group (P < 0.001). Several additional clinical trials of prophylactic G-CSF in patients with various malignancies receiving different treatment regimens have been reported [6–11].

Keywords

Meta-analysis Randomized Controlled Trials Granulocyte Colony-Stimulating Prophylaxis Chemotherapy 

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Copyright information

© Springer Science+Business Media, LLC 2010

Authors and Affiliations

  1. 1.Duke University School of MedicineDurhamUSA

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