A Monte Carlo Analysis of Peritoneal Antimicrobial Pharmacokinetics

Chapter
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 696)

Abstract

Peritoneal dialysis-associated peritonitis (PDAP) can be treated using very different regimens of antimicrobial administration, regimens that result in different pharmacokinetic outcomes and systemic exposure levels. Currently, there is no population-level pharmacokinetic framework germane to the treatment of PDAP. We coupled a differential-equation-based model of antimicrobial kinetics to a Monte Carlo simulation framework, and conducted “in silico” clinical trials to explore the anticipated effects of different antimicrobial dosing regimens on relevant pharmacokinetic parameters (AUC/MIC and time greater than 5 ×MIC) and the level of systemic exposure.

Keywords

Peritoneal dialysis In silico clinical trial 

Notes

Acknowledgements

This study is supported by NIH 7R21AI055818-02.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of MathematicsFisk UniversityNashvilleUSA

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