Nuclear Architecture in Stem Cells

Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 695)

Abstract

Fundamental features of genome regulation depend on the linear DNA sequence, cell type specific modification of DNA and chromatin-associated proteins, which locally control the expression of single genes. Architectural features of genome organization within the three-dimensional (3D) nuclear space establish preferential positioning of genes relative to nuclear subcompartments associated with specific biochemical activities, thereby influencing states of expression. The structural and temporal organization of the genome within the nucleus of stem cells, together with specific features of epigenetic and transcriptional regulation are emerging as key players that influence pluripotency and differentiation.1,2

Keywords

Leukemia Lysine Compaction Cane Triphosphate 

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  1. 1.Genome Function Group, MRC Clinical Sciences Centre, Imperial College School of MedicineHammersmith Hospital CampusLondonUK

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