Immunobiology of Biomphalaria–Trematode Interactions

  • Timothy P. Yoshino
  • Christine Coustau


As the exclusive intermediate host of the human blood fluke Schistosoma mansoni, species of the snail Biomphalaria, especially Biomphalaria glabrata, have been the subjects of numerous studies focused on the immunobiology of parasite–host interactions. With the recent applications of molecular, genomic, proteomic and glycomic approaches to the study of Biomphalaria’s immune response to schistosomes and other trematode species, there is now accumulating a wealth of information that is beginning to address the mechanisms underlying these complex parasite–host associations. In this chapter, we attempt to broadly review our past understanding of Biomphalaria immunity and integrate recent information on the cellular and molecular events surrounding initial immune responses to larval trematode infections, the consequences of immune interactions and counter-immune strategies used by these parasites.


Molecular Mimicry Larval Trematode Mother Sporocyst Encapsulation Reaction Human Blood Fluke 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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© Springer Science+Business Media LLC 2011

Authors and Affiliations

  1. 1.Department of Pathobiological SciencesUniversity of WisconsinMadisonUSA

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