Thyroid Axis, Prolactin, and Exercise

Part of the Endocrine Updates book series (ENDO, volume 29)


The endocrine system, from a classic biology perspective, is composed of a series of glandular tissues located throughout the human body, which secrete chemical substances (hormones) to modify/regulate the physiological function of target tissues. Many hormones not only have such endocrine effects, but also autocrine- and paracrine-like function. In the last few decades, many nonglandular tissues in the human body have been found to secrete hormonal.


Exercise Training Prolonged Exercise Metabolic Clearance Rate Prolactin Response Pituitary Prolactin 
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  1. 1.
    Griffin JE. The thyroid. In: Griffin JE & Odjeda SR (eds). Textbook of Endocrine Physiology, 3rd Edition. Oxford University: New York, pp. 260–283, 1996.Google Scholar
  2. 2.
    Mazzaferri EL. The thyroid. In: Mazzaferri, EL (ed). Endocrinology, 3rd Edition. Medical Examination Publishing Co.: New York, pp. 89–350, 1985.Google Scholar
  3. 3.
    McMurray RG & AC Hackney. The endocrine system and exercise. In: Garrett W, Kirkendahl D (eds). Exercise & Sports Science. Williams & Wilkins Publisher: New York, pp. 135–162, 2000.Google Scholar
  4. 4.
    McMurray RG & AC Hackney. Interactions of metabolic hormones, adipose tissue and exercise. Sports Med. 35(5): 393–412, 2005.CrossRefPubMedGoogle Scholar
  5. 5.
    Galbo H. The hormonal response to exercise. Diabetes Metab Rev. 1(4): 385–408, 1986.CrossRefPubMedGoogle Scholar
  6. 6.
    McMurray RG, TE Eubanks & AC Hackney. Nocturnal hormonal responses to weight training exercise. Eur J Appl Physiol. 72: 121–126, 1995.CrossRefGoogle Scholar
  7. 7.
    Hackney AC & A Viru. Research methodology: issues with endocrinological measurements in exercise science and sport medicine. J Athletic Training. 43(6): 631–639, 2008.CrossRefGoogle Scholar
  8. 8.
    Berchtold P, M Berger & HJ Uppers. Non-glucoregulatory hormones (T4, T3, rT3 and testosterone) during physical exercise in juvenile type diabetes. Horm Metab Res. 10: 269–273, 1978.CrossRefPubMedGoogle Scholar
  9. 9.
    Moore AW, S Timmerman, KK Brownlee, DA Rubin & AC Hackney. Strenuous, fatiguing exercise: relationship of cortisol to circulating thyroid hormones. Int J Endocrino Metab. 1: 18–24, 2005.Google Scholar
  10. 10.
    Hackney AC & TP Gulledge. Thyroid responses during an 8 hour period following aerobic and anaerobic exercise. Physiol Res. 43: 1–5, 1994.PubMedGoogle Scholar
  11. 11.
    Opstad K. Circadian rhythm of hormones is extinguished during prolonged physical stress, sleep and energy deficiency in young men. Eur J Endocrinol. 131(1): 56–66, 1994.CrossRefPubMedGoogle Scholar
  12. 12.
    Irvine CHG. Effects of exercise on thyroxine degradation in athletes and non-athletes. J Clin Endocr. 28: 942–948, 1968.CrossRefPubMedGoogle Scholar
  13. 13.
    Baylor LS & AC Hackney. Resting thyroid and leptin hormone changes in women following intense, prolonged exercise training. Eur J Appl Physiol. 88(4–5): 480–484, 2003.CrossRefPubMedGoogle Scholar
  14. 14.
    Douyon L & DE Schteingart. Effect of obesity and starvation on thyroid hormone, growth hormone, and cortisol secretion. Endocrinol Metab Clin North Am. 31(1): 173–189, 2002.CrossRefPubMedGoogle Scholar
  15. 15.
    Balsam A & LE Leppo. Effect of physical training on the metabolism of thyroid hormones in man. J Appl Physiol. 38: 212–215, 1975.PubMedGoogle Scholar
  16. 16.
    Terjung RL & WW Winder. Exercise and thyroid function. Med Sci Sports. 7(1): 20–26, 1974.Google Scholar
  17. 17.
    DeNayer P, M Ostyn & M DeVisscher. Effect de l’entrainement sur le taux de la thyroxine libre chez l’athlete. Annl D’Endocr. 31: 721–723, 1970.Google Scholar
  18. 18.
    Ben-Jonathan N, ER Hugo, TG Brandebourg & CR LaPensee. Focus on prolactin as a metabolic hormone. Trends Endocrinol. 17(3): 110–116, 2006.CrossRefGoogle Scholar
  19. 19.
    Viru A & M Viru. Biochemical Monitoring of Sport Training. Human Kinetics Publishing, Champaign, IL, 2001.Google Scholar
  20. 20.
    Daly W, CA Seegers, DA Rubin, JD Dobridge & AC Hackney. Relationship between stress hormones and testosterone with prolonged endurance exercise. Eur J Appl Physiol. 93: 375–380, 2005.CrossRefPubMedGoogle Scholar
  21. 21.
    Radomski MW, M Cross & A Buguet. Exercise-induced hyperthermia and hormonal responses to exercise. Can J Physiol Pharmacol. 76: 547–552, 1998.CrossRefPubMedGoogle Scholar
  22. 22.
    Hackney AC. Characterization of the prolactin response to prolonged endurance exercise. Acta Kinesiologiae (University of Tartu). 13: 31–38, 2008.Google Scholar
  23. 23.
    Ansley L, G Marvin, A Sharma, MJ Kendall, DA Jones & MW Bridge. The effect of head cooling on endurance and neuroendocrine responses to exercise in warm conditions. Physiol Res. 57(6): 863–872, 2008.PubMedGoogle Scholar
  24. 24.
    Hackney AC, RJ Ness & A Schreiber. Effects of endurance exercise on nocturnal hormone concentrations in males. Chronobiol Int. 6(4): 341–346, 1989.CrossRefPubMedGoogle Scholar
  25. 25.
    Hackney AC, MC Premo & RG McMurray. Influence of aerobic versus anaerobic exercise on the relationship between reproductive hormones in men. J Sports Sci. 13(4): 305–311, 1995.CrossRefPubMedGoogle Scholar
  26. 26.
    Hackney AC, RL Sharp, WS Runyan & RJ Ness. Relationship of resting prolactin and testosterone changes in males during intensive training. British J Sports Med. 23(3): 194, 1989.CrossRefGoogle Scholar
  27. 27.
    Wheeler GD, SR Wall, AN Belcastro & DC Cumming. Reduced serum testosterone and prolactin levels in male distance runners. JAMA. 252(4): 514–516, 1984.CrossRefPubMedGoogle Scholar
  28. 28.
    Hackney AC, RL Sharp, W Runyan, Y Kim & RJ Ness. Effects of intensive training on the prolactin response to submaximal exercise in males. J Iowa Acad Sci. 96(2): 52–53, 1989.Google Scholar
  29. 29.
    Boyden TW, RW Pamenter, D Grosso, P Stanforth, T Rotkis & JH Wilmore. Prolactin responses, menstrual cycles, and body composition of women runners. J Clin Endocrinol Metab. 54(4): 711–714, 1982.CrossRefPubMedGoogle Scholar
  30. 30.
    Hackney AC, WE Sinning & BC Bruot. Hypothalamic-pituitary-testicular axis function in endurance trained males. Int J Sports Med. 11: 298–303, 1990.CrossRefPubMedGoogle Scholar
  31. 31.
    Hackney AC & JD Dobridge. Thyroid hormones and the interrelationship of cortisol and prolactin: influence of prolonged, exhaustive exercise. Pol J Endocrinol. 60(4): 252–257, 2009.Google Scholar
  32. 32.
    Ortega E. Neuroendocrine mediators in the modulation of phagocytosis by exercise: physiological implications. Exercise Immunol Rev. 9: 70–93, 2003.Google Scholar
  33. 33.
    Joyner M & EF Coyle. Endurance exercise performance: the physiology of champions. J Physiol. 586: 35–44, 2008.CrossRefPubMedGoogle Scholar

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Applied Physiology Laboratory, Department of Exercise & Sport Science, Department of Nutrition – School of Public HealthUniversity of North CarolinaChapel HillUSA

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