The Star Family Member

QKI and Cell Signaling
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 693)


The family of Signal Transduction and Activators of RNA (STAR) is named based on the intriguing potential for these proteins to connect cell signaling directly to the homeostasis of their mRNA ligands. Besides the commonly shared single RNA binding domain that displays heterogeneous nuclear ribonucleoprotein K homology (KH), STAR proteins also harbor domains predicted to bind critical components in signal transduction pathways, in particular the Src-family protein tyrosine kinases (Src-PTK s). Indeed, accumulating evidence in recent years has demonstrated that the RNA-binding activity and the homeostasis of downstream mRNA targets of STAR proteins can be regulated by phosphorylation in response to various extracellular signals. This chapter provides a short review of the STAR member QKI, focusing on the essential role of QKI in development of the central nervous system, possible mechanisms by which QKI may link cell signaling to the cellular behavior of its mRNA targets and how QKI dysregulation may contribute to human diseases.


Myelin Basic Protein Cell Cycle Exit Myelin Development Oligodendrocyte Precursor Cell Migration mRNA Ligand 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  1. 1.Emory UniversityAtlantaUSA

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