Protein Metabolism and Lifespan in Caenorhabditis elegans

  • Geert Depuydt
  • Jacques R. Vanfleteren
  • Bart P. Braeckman
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 694)


Lifespan of the versatile model system Caenorhabditis elegans can be extended by a decrease of insulin/IGF-1 signaling, TOR signaling, mitochondrial function, protein synthesis and dietary intake. The exact molecular mechanisms by which these modulations confer increased life expectancy are yet to be determined but increased stress resistance and improved protein homeostasis seem to be of major importance. In this chapter, we explore the interactions among several genetic pathways and cellular functions involved in lifespan extension and their relation to protein homeostasis in C. elegans. Several of these processes have been associated, however some relevant data are conflicting and further studies are needed to clarify these interactions. In mammals, protein homeostasis is also implicated in several neurodegenerative diseases, many of which can be modeled in C. elegans.


Caloric Restriction Dietary Restriction Molecular Chaperone Protein Turnover Lifespan Extension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.


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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Geert Depuydt
    • 1
  • Jacques R. Vanfleteren
    • 1
  • Bart P. Braeckman
    • 1
  1. 1.Department of BiologyGhent UniversityGhentBelgium

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