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Regulation of mRNA Translation as a Conserved Mechanism of Longevity Control

  • Ranjana Mehta
  • Devon Chandler-Brown
  • Fresnida J. Ramos
  • Lara S. Shamieh
  • Matt Kaeberlein
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 694)

Abstract

Appropriate regulation of mRNA translation is essential for growth and survival and the pathways that regulate mRNA translation have been highly conserved throughout eukaryotic evolution. Translation is controlled by a complex set of mechanisms acting at multiple levels, ranging from global protein synthesis to individual mRNAs. Recently, several mutations that perturb regulation of mRNA translation have also been found to increase longevity in three model organisms: the budding yeast Saccharomyces cerevisiae, the nematode Caenorhabditis elegans and the fruit fly Drosophila melanogaster. Many of these translation control factors can be mapped to a single pathway downstream of the nutrient responsive target of rapamycin (TOR) kinase. In this chapter, we will review the data suggesting that mRNA translation is an evolutionarily conserved modifier of longevity and discuss potential mechanisms by which mRNA translation could influence aging and age-associated disease in different species.

Keywords

Caloric Restriction Spinal Muscular Atrophy Tuberous Sclerosis Complex mRNA Translation Life Span Extension 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Ranjana Mehta
    • 1
  • Devon Chandler-Brown
    • 1
  • Fresnida J. Ramos
    • 1
  • Lara S. Shamieh
    • 1
  • Matt Kaeberlein
    • 1
  1. 1.Department of PathologyUniversity of WashingtonSeattleUSA

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