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Post-Translational Modification of Cellular Proteins by Ubiquitin and Ubiquitin-Like Molecules: Role in Cellular Senescence and Aging

  • Johannes Grillari
  • Regina Grillari-Voglauer
  • Pidder Jansen-Dürr
Part of the Advances in Experimental Medicine and Biology book series (AEMB, volume 694)

Abstract

Ubiquitination of endogenous proteins is one of the key regulatory steps that guides protein degradation through regulation of proteasome activity. During the last years evidence has accumulated that proteasome activity is decreased during the aging process in various model systems and that these changes might be causally related to aging and age-associated diseases. Since in most instances ubiquitination is the primary event in target selection, the system of ubiquitination and deubiquitination might be of similar importance. Furthermore, ubiquitination and proteasomal degradation are not completely congruent, since ubiquitination confers also functions different from targeting proteins for degradation.

Depending on mono- and polyubiquitination and on how ubiquitin chains are linked together, post-translational modifications of cellular proteins by covalent attachment of ubiquitin and ubiquitin-like proteins are involved in transcriptional regulation, receptor internalization, DNA repair, stabilization of protein complexes and autophagy. Here, we summarize the current knowledge regarding the ubiquitinome and the underlying ubiquitin ligases and deubiquitinating enzymes in replicative senescence, tissue aging as well as in segmental progeroid syndromes and discuss potential causes and consequences for aging.

Keywords

Proliferate Cell Nuclear Antigen Cellular Senescence Fanconi Anemia Senescent Cell Premature Senescence 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Johannes Grillari
    • 1
  • Regina Grillari-Voglauer
    • 1
  • Pidder Jansen-Dürr
    • 1
  1. 1.Institute of Applied Microbiology, Department of BiotechnologyUniversity for Natural Resources and Applied Life Sciences, ViennaViennaAustria

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