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The Monotonous Small-Cell Pattern

  • Stefan E. Pambuccian
  • Ricardo H. Bardales
Chapter
Part of the Essentials in Cytopathology book series (EICP, volume 10)

Abstract

Small lymphocytes measure <12 μm in diameter, equivalent to the size of a histiocyte nucleus, a segmented neutrophil, or 1.5 to 2 times the size of an erythrocyte. The presence of a monotonous proliferation of small lymphoid cells in an enlarged round and rubbery lymph node is abnormal, and the cytologic findings should be correlated with the clinical scenario. Chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) and the resolving or quiescent phase of a reactive lymphoid hyperplasia are the main and most common entities considered in the differential diagnosis and must be distinguished from other neoplastic and non-neoplastic processes. The following is a list of entities showing the monotonous small-cell pattern. The cytologic description is based on Romanovsky-stained, air-dried smears. We use the WHO classification and nomenclature for lymphoid neoplasms unless otherwise is noted.

Keywords

Hodgkin Lymphoma Follicular Dendritic Cell Castleman Disease Follicular Dendritic Cell Sarcoma Reactive Lymphoid Hyperplasia 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.Department of Lab. Medicine & PathologyUniversity of MinnesotaMinneapolisUSA
  2. 2.Outpatient Pathology AssociatesSacramentoUSA

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