Bayesian Clinical Trials

  • Ming-Hui Chen
  • Dipak K. Dey
  • Peter Müller
  • Dongchu Sun
  • Keying Ye
Chapter

Abstract

Innovative clinical trial design is one of the currently most exciting and high impact frontiers in a Bayesian analysis. The increasingly complex nature of clinical study designs and the increasing pressures for efficient and ethical design naturally lead to Bayesian approaches. In this chapter we discuss some examples of specific research problems, including adaptive and sequential trial design, sample size choice determination for longitudinal studies, and subgroup analysis.

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Copyright information

© Springer New York 2010

Authors and Affiliations

  • Ming-Hui Chen
    • 1
  • Dipak K. Dey
    • 1
  • Peter Müller
    • 2
  • Dongchu Sun
    • 3
  • Keying Ye
    • 4
  1. 1.Department of StatisticsUniversity of ConnecticutStorrsUSA
  2. 2.Department of BiostatisticsThe University of Texas, M. D. Anderson Cancer CenterHoustonUSA
  3. 3.Department of StatisticsUniversity of Missouri-ColumbiaColumbiaUSA
  4. 4.Department of Management Science and Statistics, College of BusinessUniversity of Texas at San AntonioSan AntonioUSA

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