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Syndromes Associated with Bladder Pain Syndrome as Clues to its Pathogenesis

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Bladder Pain Syndrome

Abstract

Over the last decade, what were once distinct pathways to understanding the pathogenesis of bladder pain syndrome (BPS) have become fainter. Fortunately, during this time several investigative groups intensively have been examining the association with BPS of several syndromes with symptoms outside the bladder (non-bladder syndromes, NBSs) and in so doing opened a new exploratory path.

The NBSs are fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, sicca syndrome, chronic pelvic pain, migraine, allergies, asthma, depression, anxiety, temporomandibular disorder, low back pain, and vulvodynia. Three findings about these NBSs are pertinent to BPS pathogenesis: (1) many NBSs are associated with BPS; (2) many NBSs are associated with each other; and (3) many NBSs precede the onset of BPS.

These findings have generated three hypotheses: (a) that BPS initiates a pathophysiology that results in NBSs, (b) that NBSs initiate a pathophysiology that results in BPS, and (c) that a preceding pathophysiology results in the NBSs and BPS. A well-designed longitudinal study likely will be necessary to distinguish among these three hypotheses.

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Author information

Authors and Affiliations

  1. Medicine and Epidemiology and Public Health, University of Maryland School of Medicine, 10 South Pine St, Baltimore, MD, 21201, USA

    John W. Warren M.D.

  2. Departments of Immunology and Internal Medicine, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands

    Joop P. van de Merwe M.D., Ph.D.

  3. Urology Department, Kingston General Hospital, Queen’s University, Kingston, ON, Canada

    J. Curtis Nickel M.D., F.R.C.S.C.

Authors
  1. John W. Warren M.D.
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  2. Joop P. van de Merwe M.D., Ph.D.
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  3. J. Curtis Nickel M.D., F.R.C.S.C.
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Corresponding author

Correspondence to John W. Warren M.D. .

Editor information

Editors and Affiliations

  1. University of Copenhagen, Department of Urology, Herlev Hospital, Herlev, 2730, Denmark

    Jørgen Nordling

  2. University Hospital Antwerp, Department of Urology, and Antwerp University, Edegem, 2650, Belgium

    Jean Jacques Wyndaele

  3. and Internal Medicine, Erasmus MC,, Departments of Immunology, University Medical Center Rotterdam, Rotterdam, 3141 XW, Netherlands

    Joop P. van de Merwe

  4. Koege Hospital, Department of Clinical Biochemistry, University of Copenhagen, Copenhagen, 4600, Denmark

    Pierre Bouchelouche

  5. Department Obstetrics and Gynecology, Department of Urogynecology S.Carlo-IDI, Catholic University, Rome, 00165, Italy

    Mauro Cervigni

  6. Institute of Clinical Sciences, Department of Urology, Sahlgrens Academy at University of Gothenburg, Göteborg, 41345, Sweden

    Magnus Fall

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Warren, J.W., van de Merwe, J.P., Nickel, J.C. (2013). Syndromes Associated with Bladder Pain Syndrome as Clues to its Pathogenesis. In: Nordling, J., Wyndaele, J., van de Merwe, J., Bouchelouche, P., Cervigni, M., Fall, M. (eds) Bladder Pain Syndrome. Springer, Boston, MA. https://doi.org/10.1007/978-1-4419-6929-3_7

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  • DOI: https://doi.org/10.1007/978-1-4419-6929-3_7

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