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Receptor-Based Discovery Strategies for Insecticides and Parasiticides: A Review

  • Debra Woods
  • Cheryl Butler
  • Tracey Williams
  • Karen Greenwood
Part of the Advances in Experimental Medicine and Biology book series (volume 692)

Abstract

Drug discovery is an iterative process with high risks and low chance of success. New genomics technologies allow veterinary medicine and agrochemical companies to validate and functionally screen new receptor-based targets, including neuropeptide G-protein coupled receptors, which were previously not amenable to high throughput screening. However this is just the first step in a long process to translate a mechanistic assay hit into a drug on the market. In addition to effectively eradicating pests on crops and parasites on their host, the molecules must also be safe, cheap to synthesise, formulatable and patentable. This is a costly process in which early attrition of unsuitable molecules is key to any successful program. Although first principle discovery is risky the ultimate benefits are considerable and future genomics resources will help to generate higher quality hits to strengthen the discovery pipeline.

Keywords

Drug Discovery Structure Activity Relationship Mechanistic Screen Pheromone Response Pathway Chemical Lead 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Landes Bioscience and Springer Science+Business Media 2010

Authors and Affiliations

  • Debra Woods
    • 1
  • Cheryl Butler
    • 2
  • Tracey Williams
    • 3
  • Karen Greenwood
    • 3
  1. 1.Pfizer Animal Health, Pfizer IncKalamazooUSA
  2. 2.Pfizer Global Research & Development, Pfizer Ltd.SandwichUK
  3. 3.Pfizer Animal HealthKalamazooUSA

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